Human Translational Core

摘要 人类翻译核心的目标是通过以下方式促进从工作台到床边的翻译研究 为圣地亚哥消化疾病研究中心的成员提供随时接触人类的机会 消化系统疾病患者特征良好的队列中的生物菌群。此外，核心将提供 检查在动物和体外进行的基础研究中出现的范例的临床专业知识 它们与消化系统疾病患者的临床表型有关。核心将由HIGH领导 加州大学圣地亚哥分校(UCSD)资深临床和翻译研究人员 消化内科，罗希特·伦巴博士担任主任，威廉·桑德伯恩博士担任联席主任，希拉博士担任主任 克罗担任联合调查员。伦巴博士和桑德伯恩博士已经在 非酒精性脂肪肝(NAFLD)中心和炎症性肠病(IBD)中心。 拟议的核心将建立在这些成就的基础上，并显著扩展和精简 来自具有良好特征的消化系统疾病患者的生物标本以及适当的对照。已建立 这一核心的优势包括核心领导在翻译相关研究方面的杰出记录 胃肠道和肝脏疾病的炎症；他们在患者详细表型方面的经验 消化系统疾病；获得现有的和特征良好的特定消化系统疾病患者队列； 获得现有人类生物标本的生物储存库；协同作用和状态-- 最先进的数据管理资源；以及强大的病理学和生物统计学专业知识。这一核心将 通过以下方式与临床前模型、微生物学和功能基因组学核心进行互动和补充 促进研究将动物模型中的生物标记物和临床前数据与患者的特定结果联系起来 患有消化系统疾病。人类翻译的核心有以下目标：1.收集、处理和 注解人体组织样本，包括肝脏活检、内窥镜胃肠组织、全血、 血浆、血清、外周血单核细胞(PBMC)和粪便；2.提供人类生物样品 与患者元数据一起提供给中心调查人员；3.提供临床、生物统计学和病理学 咨询服务，以及培训机会。因此，该核心将通过以下方式使中心成员受益 提供可靠、具成本效益的服务，以扩大其研究和创新的范围和创新 与人类消化道疾病的相关性。

Summary The objective of the Human Translational Core is to facilitate bench-to-bedside translational studies by providing members of the San Diego Digestive Diseases Research Center ready access to human biospecimens of well-characterized cohorts of patients with digestive diseases. Moreover, The Core will provide clinical expertise for examining paradigms that emerge from basic studies conducted in animals and in vitro and relating them to clinical phenotypes seen in patients with digestive diseases. The Core will be led by highly accomplished clinical and translational researchers from the University of California, San Diego (UCSD) Division of Gastroenterology, with Dr. Rohit Loomba as Director, Dr. William Sandborn as Co-Director, and Dr. Sheila Crowe as Co-Investigator. Drs. Loomba and Sandborn have already established modest biorepositories in the Nonalcoholic Fatty Liver Disease (NAFLD) Center and Inflammatory Bowel Disease (IBD) Center, respectively. The proposed Core will build on these achievements and markedly expand and streamline the repository of biospecimens from well-characterized digestive disease patients as well as appropriate controls. Established strengths of this Core include the outstanding track record of the Core leadership in translational research related to inflammation in gastrointestinal and liver diseases; their experience in detailed phenotyping of patients with digestive diseases; access to existing and well-characterized cohorts of patients with specific digestive diseases; access to a biorepository of existing human biospecimens; synergistic interactions and the availability of state- of-the-art data management resources; and strong pathological and biostatistical expertise. This Core will interact with and complement the Preclinical Models and Microbiomics and Functional Genomics Cores by facilitating research to relate biomarkers and preclinical data from animal models to specific outcomes in patients with digestive diseases. The Human Translational Core has the following Aims: 1. To collect, process and annotate human tissue samples, including liver biopsies, endoscopic gastrointestinal tissues, whole blood, plasma, serum, peripheral blood mononuclear cell (PBMC), and stool; 2. To provide human biospecimens coupled with patient metadata to Center investigators; 3. To offer clinical, biostatistical and pathological consultation services, as well as training opportunities. Thus, this Core will benefit the Center members by providing reliable, cost-effective services for enhancing the scope and innovation of their research and its relevance to human diseases of the digestive tract.