Human Translational Core

人类翻译核心

• 批准号: 10617218
• 负责人: ROHIT LOOMBA
• 金额: $ 26.9万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617218
• 关键词: Achievement; Address; Animal Model; Animals; Biological Markers; Biological Specimen Banks; Biometry; California; Cell Culture Techniques; Clinical; Collection; Complement; Computerized Medical Record; Consultations; Coupled; Data Analyses; Data Management Resources; Diagnosis; Digestive System Disorders; Disease; Endoscopic Biopsy; Face; Feces; Gastroenterology; Gastrointestinal Diseases; Human; In Vitro; Inflammation; Inflammatory Bowel Diseases; Knowledge; Leadership; Link; Liver; Liver diseases; Metadata; Needle biopsy procedure; Online Systems; Outcome; Pathogenesis; Pathologic; Patients; Peripheral Blood Mononuclear Cell; Phenotype; Plasma; Pre-Clinical Model; Process; Research; Research Design; Research Personnel; Sample Size; Sampling; Serum; Services; System; Testing; Tissue Banks; Tissue Sample; Tissues; Translational Research; Universities; Upper digestive tract structure; Whole Blood; animal data; bench-to-bedside translation; biobank; chronic liver disease; clinical phenotype; cohort; cost effective; experience; functional genomics; gastrointestinal; human disease; human study; human tissue; innovation; liver biopsy; member; microbiome research; non-alcoholic fatty liver disease; phenotypic data; pre-clinical; sample collection; training opportunity; translational scientist; translational study

Summary The objective of the Human Translational Core is to facilitate bench-to-bedside translational studies by providing members of the San Diego Digestive Diseases Research Center ready access to human biospecimens of well-characterized cohorts of patients with digestive diseases. Moreover, The Core will provide clinical expertise for examining paradigms that emerge from basic studies conducted in animals and in vitro and relating them to clinical phenotypes seen in patients with digestive diseases. The Core will be led by highly accomplished clinical and translational researchers from the University of California, San Diego (UCSD) Division of Gastroenterology, with Dr. Rohit Loomba as Director, Dr. William Sandborn as Co-Director, and Dr. Sheila Crowe as Co-Investigator. Drs. Loomba and Sandborn have already established modest biorepositories in the Nonalcoholic Fatty Liver Disease (NAFLD) Center and Inflammatory Bowel Disease (IBD) Center, respectively. The proposed Core will build on these achievements and markedly expand and streamline the repository of biospecimens from well-characterized digestive disease patients as well as appropriate controls. Established strengths of this Core include the outstanding track record of the Core leadership in translational research related to inflammation in gastrointestinal and liver diseases; their experience in detailed phenotyping of patients with digestive diseases; access to existing and well-characterized cohorts of patients with specific digestive diseases; access to a biorepository of existing human biospecimens; synergistic interactions and the availability of state- of-the-art data management resources; and strong pathological and biostatistical expertise. This Core will interact with and complement the Preclinical Models and Microbiomics and Functional Genomics Cores by facilitating research to relate biomarkers and preclinical data from animal models to specific outcomes in patients with digestive diseases. The Human Translational Core has the following Aims: 1. To collect, process and annotate human tissue samples, including liver biopsies, endoscopic gastrointestinal tissues, whole blood, plasma, serum, peripheral blood mononuclear cell (PBMC), and stool; 2. To provide human biospecimens coupled with patient metadata to Center investigators; 3. To offer clinical, biostatistical and pathological consultation services, as well as training opportunities. Thus, this Core will benefit the Center members by providing reliable, cost-effective services for enhancing the scope and innovation of their research and its relevance to human diseases of the digestive tract.

总结 Human Translational Core的目标是通过以下方式促进实验室到床边的翻译研究： 为圣地亚哥消化疾病研究中心的成员提供人类 消化系统疾病患者的良好表征队列的生物标本。此外，核心将提供 临床专业知识，用于检查在动物和体外进行的基础研究中出现的范例， 将它们与消化系统疾病患者的临床表型相关联。核心将由 来自加州大学圣地亚哥分校（UCSD）的临床和转化研究人员 Rohit Loomba博士担任主任，William Sandborn博士担任联合主任，Sheila博士 Crowe作为合作调查员。Loomba博士和Sandborn博士已经建立了适度的生物储存库， 非酒精性脂肪肝病（NAFLD）中心和炎症性肠病（IBD）中心。 拟议的核心将在这些成就的基础上，显著扩大和精简 来自充分表征的消化系统疾病患者的生物样本以及适当的对照。建立 该核心的优势包括核心领导在翻译研究相关领域的杰出业绩， 胃肠道和肝脏疾病中的炎症;他们在胃肠道疾病患者的详细表型分析中的经验 消化系统疾病;获得现有的和特征明确的特定消化系统疾病患者队列; 获得现有人类生物标本的生物储存库;协同作用和国家- 最先进的数据管理资源;以及强大的病理学和生物统计学专业知识。这一核心将 通过以下方式与临床前模型、微生物学和功能基因组学核心相互作用并对其进行补充： 促进研究，将动物模型的生物标志物和临床前数据与患者的特定结果联系起来 消化系统疾病人类翻译核心有以下目标：1。收集、处理和 注释人体组织样本，包括肝活检、内窥镜胃肠道组织、全血， 血浆、血清、外周血单核细胞（PBMC）和粪便; 2.提供人体生物标本 与患者元数据一起提供给中心研究者; 3.提供临床、生物统计学和病理学 咨询服务以及培训机会。因此，该核心将使中心成员受益， 提供可靠的，具有成本效益的服务，以扩大其研究的范围和创新， 与人类消化道疾病的相关性。