Genetic control of developmental timing
发育时间的遗传控制
基本信息
- 批准号:10395981
- 负责人:
- 金额:$ 82.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-05-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAnimalsBiogenesisCaenorhabditis elegansCell divisionCellsComplexCouplingDevelopmentDiapauseDiseaseEmbryoEnsureEventEvolutionEyeGeneticGenetic TranscriptionGenetic studyHomeostasisHumanLearningLifeMalignant NeoplasmsMicroRNAsMolecularMoltingMorphogenesisNerve DegenerationOrganismPathway interactionsPatternPeriodicityProcessRoleSignal TransductionStressTestingTissuescell fate specificationenvironmental stressorfitnessphysiologic stressorrepairedresilience
项目摘要
Project Summary/Abstract
Animal development involves the precise control of cell division, cellular quiescence, cell fate
specification, differentiation, and morphogenesis. All these processes are controlled by cell
signaling and genetic regulatory mechanisms whose components and interactions have been
shaped by evolution for maximum fitness. We study genetic regulatory networks in C. elegans
that are responsible for orchestrating temporal patterns of developmental events during larval
development, with an eye on uncovering principles and mechanisms that ensure robust
coordination of developmental progression throughout the animal. We will expand on our
previous studies of the roles of microRNA pathways in developmental robustness to investigate
mechanisms coupling microRNA biogenesis to developmental progression under conditions of
stress. We will continue to explore the roles of microRNAs and other factors in coordinating
transcriptional and post-transcriptional regulatory mechanisms for robust temporal control of
development, particularly in the context of deeply conserved microRNAs and microRNA target
motifs. We will investigate the relationship of the periodic components of worm development --
particularly molting and larval diapause – to the progressive advancement of stage identify and
cell fate progression, with the aim of testing hypotheses for how cell divisions and cell fate
transitions are coordinated on the organism level.
项目总结/摘要
动物的发育涉及对细胞分裂、细胞静止、细胞命运的精确控制
特化、分化和形态发生。所有这些过程都是由细胞控制的
信号和遗传调节机制,其组成部分和相互作用已被
为了最大的适应性而进化。我们研究了C. elegans
负责协调幼虫时期发育事件的时间模式
发展,着眼于发现确保强有力的
协调整个动物的发育进程。我们将扩大我们的
以前的研究microRNA途径在发育稳健性中的作用,
在以下条件下,将microRNA生物发生与发育进程耦合的机制
应力我们将继续探索microRNA和其他因素在协调
转录和转录后调节机制,用于对
发展,特别是在高度保守的microRNA和microRNA靶点的背景下,
图案我们将研究蠕虫发育的周期性成分之间的关系,
特别是蜕皮和幼虫滞育-阶段识别和
细胞命运进程,目的是测试细胞分裂和细胞命运的假设
在生物体水平上协调过渡。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Victor Ambros其他文献
Victor Ambros的其他文献
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{{ truncateString('Victor Ambros', 18)}}的其他基金
microRNA gene networks regulating responses to environment
microRNA基因网络调节对环境的反应
- 批准号:
8698074 - 财政年份:2014
- 资助金额:
$ 82.03万 - 项目类别:
microRNA gene networks regulating responses to environment
microRNA基因网络调节对环境的反应
- 批准号:
8851625 - 财政年份:2014
- 资助金额:
$ 82.03万 - 项目类别:
microRNA gene networks regulating responses to environment
microRNA基因网络调节对环境的反应
- 批准号:
9036276 - 财政年份:2014
- 资助金额:
$ 82.03万 - 项目类别:
Developmental Regulation of MicroRNA Expression
MicroRNA 表达的发育调控
- 批准号:
7933637 - 财政年份:2009
- 资助金额:
$ 82.03万 - 项目类别:
Functional analysis of microRNA genes in Drosophila
果蝇microRNA基因的功能分析
- 批准号:
6725267 - 财政年份:2004
- 资助金额:
$ 82.03万 - 项目类别:
Functional analysis of microRNA genes in Drosophila
果蝇microRNA基因的功能分析
- 批准号:
6843745 - 财政年份:2004
- 资助金额:
$ 82.03万 - 项目类别:
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