Center for chronic pain and drug abuse

慢性疼痛和药物滥用中心

• 批准号: 10400508
• 负责人: Apkar Vania Apkarian
• 金额: $ 1.99万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400508
• 关键词: Analgesics; Animals; Brain; Drug abuse; Exposure to; Goals; Human; Internships; Modeling; National Institute of Drug Abuse; Opiate Addiction; Opioid; Opioid Analgesics; Pain; Pain Clinics; Pain Research; Postdoctoral Fellow; Property; Research; Research Assistant; Role; Shapes; Students; Training; addiction; brain circuitry; career development; chronic pain; design; experience; graduate student; multidisciplinary; summer student; undergraduate research; undergraduate student

Project Summary/Abstract The Pain Center is designed to study and enhance understanding of the mechanisms of chronic pain and the interaction between opioid analgesia and opioid dependence. Our main goal is to build upon the recent discovery that chronic pain is shaped by the same brain circuitry that controls opioid addiction. We focus on pain, addiction, and opioid research in humans and in animals’ models. All projects are united by the common goal to unravel how the mesocorticolimbic circuitry in chronic pain is reorganized by repeated exposure to opioids, and how this plasticity shapes the analgesic and addictive properties of opioids. The Pain Center is composed of an interdisciplinary team of PIs. All of us have trained many graduate students and post-doctoral fellows and takes very seriously our role in facilitating the career development of the Pain Center students. The NIDA supported summer students will be able to interact with a multidisciplinary team composed by several post-doctoral fellows, graduate, undergraduate students and research assistants. There are multiple opportunities for them to engage in both human and animal mechanistic studies. As these summer students have no prior research experience, we will need to explore with them how and in what capacity they can be engaged in the ongoing research of the Pain Center.

项目摘要/摘要 疼痛中心旨在研究和加强对慢性疼痛机制的了解和 阿片类镇痛与阿片依赖之间的相互作用。我们的主要目标是在 最近的发现，慢性疼痛是由控制阿片成瘾的同一大脑电路塑造的。 我们专注于人类和动物模型中的疼痛、成瘾和阿片类药物研究。所有项目都是联合的 共同的目标是揭开慢性疼痛的中皮质边缘回路是如何重组的 反复接触阿片类药物，以及这种可塑性如何塑造阿片类药物的止痛和成瘾特性 阿片类药物。 疼痛中心由一个由PI组成的跨学科团队组成。我们所有人都培养了许多毕业生 学生和博士后研究员，并非常重视我们在促进职业发展方面的作用 疼痛中心的学生。 NIDA支持的暑期学生将能够与由以下人员组成的多学科团队进行互动 几名博士后研究员、研究生、本科生和研究助理。确实有 为他们提供了多个从事人类和动物机械研究的机会。就像这些 暑期班的学生没有以前的研究经验，我们需要与他们一起探索如何以及在什么方面 他们可以从事疼痛中心的持续研究。