Functional Neuroanatomy Correlates of Worry in Older Adults

摘要 R01 MH108509[FINA-老年人焦虑的功能神经解剖学相关性]旨在 描述老年人严重焦虑和情绪调节过程之间的神经生物学途径 成年人。我们最近申请了竞争续集2 R01 MH108509-06[原始大脑-效果 关于衰老和痴呆症风险的沉思、焦虑和担忧]。通过续签，我们的目标是确定 沉思、焦虑和担忧(原始)表型导致加速衰老的途径 并增加了ADRD的风险。更新的目的是跟随我们目前特征良好的老年人队列， 我们计划增加150名新的老年参与者，他们同样是在反省的维度上招募的， 焦虑和担忧。我们将在两年内重复评估，为我们提供三个时间点 原始队列和新队列的两个时间点。这将使我们能够随着时间的推移识别和监控 神经和生物途径导致从原始到大脑和身体老化。RAW中建议的总N为 150名(国际泳联参与者)+150名新参与者。为了实现所需的设计和功率， 更新研究依赖于国际泳联150名老年人的队列。COVID大流行的缓解工作 都极大地影响了国际泳联的拨款，严重的延误和中断限制了能力 以推进当前的研究性研究。拟议补编的目的将是继续征聘一名 在国际泳联预定结束(2021年6月)后再延长五个月，这将使我们能够达到拟议的 这些资金专门用于收回停摆期间支付的工资。这对以下方面至关重要 对当前提案期间获得的数据的成功分析(基于功率计算)，但 也是为了新提案的成功。本提案响应NOT-MH-21-120，因为：1)它是 在资助的研究范围内；2)国际泳联处于获奖的最后一年；3)完成 登记人数和后续行动对当前项目的成功以及 建议续期。 1

ABSTRACT R01 MH108509 [FINA - Functional Neuroanatomy Correlates of Worry in Older Adults] was designed to characterize the neurobiological pathways linking severe worry and emotion regulation processes in older adults. We recently applied for a competing continuation 2 R01 MH108509-06 [The RAW Brain - The Effect of Rumination, Anxiety and Worry on Aging and Dementia Risk]. Through the renewal we aim to identify the pathways through which the rumination, anxiety and worry (RAW) phenotypes contribute to accelerated aging and increased ADRD risk. The renewal aims to follow our currently well-characterized cohort of older adults, and we plan to add 150 new older participants, similarly recruited on dimensional measures of rumination, anxiety, and worry. We will repeat the assessments at two-year follow-up, giving us three time points for the original cohort and two time-points for the new cohort. This will allow us to identify and monitor over time the neural and biological pathways leading from RAW to brain and body aging. The total N proposed in RAW is 150 (FINA participants) + 150 new participants. In order to achieve the required design and power, the renewal study relies on the FINA cohort of 150 older adults. The COVID pandemic mitigation efforts have impacted the FINA grant tremendously, with significant delays and interruptions that limited the ability to progress the current research study. The proposed supplement will aim to continue the recruitment for an additional five months after the scheduled end of FINA (June 2021), which will allow us to reach the proposed N. The funds are specifically aimed to recover salaries paid during shutdown. This is crucial for both the successful analysis of data obtained during the current proposal (based on power calculations) but also for the success of the renewed proposal. This proposal is responsive to NOT-MH-21-120 as: 1) it is within the scope of the funded research; 2) FINA is in the last year of the award; 3) completion of enrollment and follow-up are critical for both the success of the current project as well as the proposed renewal. 1