Functional Neuroanatomy Correlates of Worry in Older Adults

功能神经解剖学与老年人担忧的相关性

• 批准号: 10397731
• 负责人: Carmen Andreescu
• 金额: $ 11.8万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-20 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10397731
• 关键词: Administrative Supplement; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Anxiety; Area; Award; Biological; Biological Markers; Body mass index; Brain; COVID-19; COVID-19 pandemic; Cardiomyopathies; Centers for Disease Control and Prevention (U.S.); Chronic Kidney Failure; Chronic Obstructive Airway Disease; Communities; Coronary Arteriosclerosis; Data; Data Analyses; Dimensions; Disease; Elderly; Enrollment; Exposure to; Funding; Grant; Guidelines; Heart; Heart failure; Immunocompromised Host; Individual; Institutes; International; Interruption; K-Series Research Career Programs; Lead; Life; Link; Magnetic Resonance Imaging; Measures; Medical center; Monitor; Neuroanatomy; Neurobiology; Oranges; Organ Transplantation; Participant; Pathway interactions; Pennsylvania; Periodicals; Phenotype; Process; Psychiatry; Publications; Reporting; Research; Research Activity; Research Design; Research Personnel; Risk; Schedule; Smoking; Source; Structure; Study Subject; Telephone; Time; Universities; Vaccines; Wages; Work; age group; base; behavioral health; cancer diagnosis; cohort; coronavirus disease; dementia risk; design; emotion regulation; follow-up; high risk; interest; pandemic disease; parent grant; posters; recruit; relating to nervous system; research study; success; symposium; synergism; working group; β-amyloid burden

ABSTRACT R01 MH108509 [FINA - Functional Neuroanatomy Correlates of Worry in Older Adults] was designed to characterize the neurobiological pathways linking severe worry and emotion regulation processes in older adults. We recently applied for a competing continuation 2 R01 MH108509-06 [The RAW Brain - The Effect of Rumination, Anxiety and Worry on Aging and Dementia Risk]. Through the renewal we aim to identify the pathways through which the rumination, anxiety and worry (RAW) phenotypes contribute to accelerated aging and increased ADRD risk. The renewal aims to follow our currently well-characterized cohort of older adults, and we plan to add 150 new older participants, similarly recruited on dimensional measures of rumination, anxiety, and worry. We will repeat the assessments at two-year follow-up, giving us three time points for the original cohort and two time-points for the new cohort. This will allow us to identify and monitor over time the neural and biological pathways leading from RAW to brain and body aging. The total N proposed in RAW is 150 (FINA participants) + 150 new participants. In order to achieve the required design and power, the renewal study relies on the FINA cohort of 150 older adults. The COVID pandemic mitigation efforts have impacted the FINA grant tremendously, with significant delays and interruptions that limited the ability to progress the current research study. The proposed supplement will aim to continue the recruitment for an additional five months after the scheduled end of FINA (June 2021), which will allow us to reach the proposed N. The funds are specifically aimed to recover salaries paid during shutdown. This is crucial for both the successful analysis of data obtained during the current proposal (based on power calculations) but also for the success of the renewed proposal. This proposal is responsive to NOT-MH-21-120 as: 1) it is within the scope of the funded research; 2) FINA is in the last year of the award; 3) completion of enrollment and follow-up are critical for both the success of the current project as well as the proposed renewal. 1

摘要 R 01 MH 108509 [FINA -老年人担忧的功能神经解剖学相关性]旨在 描述老年人严重担忧和情绪调节过程的神经生物学通路 成年人了我们最近申请了一个竞争延续2 R 01 MH 108509 -06 [原始大脑-效果 对衰老和痴呆风险的沉思、焦虑和担忧]。通过更新，我们的目标是确定 反刍、焦虑和担忧（RAW）表型导致加速衰老的途径 增加ADRD风险。更新的目的是遵循我们目前特征良好的老年人群体， 我们计划增加150名新的老年参与者，同样是根据沉思的维度测量招募的， 焦虑和担忧我们将在两年随访时重复评估，为我们提供三个时间点， 原始队列和新队列的两个时间点。这将使我们能够识别和监测随着时间的推移， 从RAW到大脑和身体衰老的神经和生物途径。RAW中建议的总N为 150名（FINA参赛者）+ 150名新参赛者。为了实现所需的设计和功率， 更新研究依赖于150名老年人的FINA队列。COVID疫情缓解工作 已经极大地影响了国际泳联的拨款，严重的延误和中断限制了国际泳联的能力， 以推进当前的研究。拟议的补编旨在继续征聘一名 在国际泳联预定结束（2021年6月）后的另外五个月，这将使我们能够达到拟议的 N.这些资金专门用于收回关闭期间支付的工资。这对于 既成功分析了当前提案期间获得的数据（基于功率计算）， 也为新提案的成功。本提案响应NOT-MH-21-120，因为：1） 在资助的研究范围内; 2）国际泳联是在该奖项的最后一年; 3）完成 入组和随访对于当前项目的成功以及 建议更新。 1