课题基金 / 基金详情

The RAW Brain - The Effect of Rumination, Anxiety and Worry on Aging and Dementia Risk

The RAW Brain - The Effect of Rumination, Anxiety and Worry on Aging and Dementia Risk
原始大脑——沉思、焦虑和担忧对衰老和痴呆风险的影响
批准号:
10365180
负责人:
Carmen Andreescu
金额:
$155.69万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
未结题
起止时间:
2016-09-20 至 2027-06-30

项目摘要

项目成果

Carmen Andreescu的其他基金

相似基金

相关文献

中文摘要
翻译
焦虑及其障碍是心血管和心血管等几种主要衰老疾病的危险因素
英文摘要
Anxiety and its disorders are a risk factor for several major diseases of aging including cardiovascular and auto- immune diseases, Alzheimer's Disease and related dementias (ADRD). As anxiety disorders have the highest lifetime prevalence of any psychiatric illness, anxiety and its phenotypes potentially represent a highly preva- lent and modifiable risk factor for diseases of aging. However, little is known about the mechanisms underly- ing the association between anxiety and ADRD risk. Moreover, the term "anxiety" is often used as an umbrella covering multiple different categorical disorders or heterogenous symptom clusters. Overall, there is a severe paucity of data regarding 1) the pathways through which specific anxiety phenotypes impact brain and body aging; 2) the neurobiological markers contributing to increased ADRD risk among individuals with specific anxiety phenotypes. A better understanding of specific neurobiological underpinning is critical to identify tar- gets for interventions designed to prevent or limit the pernicious effect of anxiety on brain and body. Rumina- tion, global anxiety, and worry (RAW) are three distinct and highly prevalent anxiety phenotypes, that have a cummulative effect on chronic stress. We reported that worry and rumination (but not global anxiety) are as- sociated with accelerated brain aging in late-life. Additional preliminary analyses indicate that worry and rumi- nation severity are associated with other markers of brain aging such as hippocampal atrophy in subfields most vulnerable to early AD while global anxiety is associated with regional accumulation of b amyloid in critical re- gions such as precuneus and posterior cingulate, an association moderated by inflammatory markers. In this proposal, we will identify the pathways through which the RAW phenotypes contribute to accelerated aging and increased ADRD risk. We will operationalize RAW severity and examine the overall effect of RAW as well as the individual effect of each phenotype. We will test the effect of RAW by using measures of 1) hippocampal atrophy and glutamate excitotoxicity; 2) cerebrovascular burden; 3) plasma amyloid; 4) peripheral markers of chronic stress [cortisol level, proinflammatory markers, carotid intima-media thickness] and 5) markers of ac- celerated aging [senescence-associated secretory phenotype proteomic panel, telomere length and free-cell mi- tochondrial DNA]. While continuing to follow our current cohort (N=150), we will add 150 new participants, similarly recruited on dimensional measures of rumination, anxiety and worry. We will repeat the assessments at two-year followup, giving us three time points for the original cohort and two time-points for the new cohort. This study will render the largest cohort of older adults extensively characterized using clinical, neuropsycho- logical, multimodal imaging measures as well as comprehensive measures of peripheral markers of stress and aging. The blend of well-established and novel approaches (including computational methods and state of the art imaging aquisitions) will allow us to frame and answer the questions imbedded in the above aims, with the overall goal of identifying the most effective interventional and preventative targets anxious older adults.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
2/3: Recurrence markers, cognitive burden and neurobiological homeostasis in late-life depression (REMBRANDT)
Recurrence markers, cognitive burden and neurobiological homeostasis in latelife depression (REMBRANDT) - Supplement
2/3: Recurrence markers, cognitive burden and neurobiological homeostasis in late-life depression (REMBRANDT)
Functional Neuroanatomy Correlates of Worry in Older Adults
海外基金