The RAW Brain - The Effect of Rumination, Anxiety and Worry on Aging and Dementia Risk
原始大脑——沉思、焦虑和担忧对衰老和痴呆风险的影响
基本信息
- 批准号:10676718
- 负责人:
- 金额:$ 151.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-20 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAgeAgingAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAmygdaloid structureAmyloidAnxietyAnxiety DisordersAutoimmune DiseasesBiologicalBlood VesselsBrainCardiovascular DiseasesCellsChronic stressClinicalCognitiveComputing MethodologiesDataDimensionsDiseaseElderlyGlutamatesGoalsHydrocortisoneImageIndividualInflammatoryLengthLinkMachine LearningMagnetic Resonance SpectroscopyMeasuresMediatingMental disordersMitochondrial DNAModelingMonitorMultimodal ImagingNeuroanatomyNeurobiologyNeuropsychologyParticipantPathway interactionsPeripheralPhenotypePlasmaPrevalencePreventionProteomicsReportingRestRiskRisk FactorsSerumSeveritiesStressSymptomsTestingTimeaging brainanxiousarterial tortuositycarotid intima-media thicknesscerebrovascularcohortcytokinedementia riskeffective interventionexcitotoxicityfollow-uphippocampal atrophyinflammatory markermodifiable riskneuralneuromechanismnovel strategiespreventrecruitresponseruminationsenescencesymptom clustertelomeretherapy designwhite matter
项目摘要
Anxiety and its disorders are a risk factor for several major diseases of aging including cardiovascular and auto-
immune diseases, Alzheimer's Disease and related dementias (ADRD). As anxiety disorders have the highest
lifetime prevalence of any psychiatric illness, anxiety and its phenotypes potentially represent a highly preva-
lent and modifiable risk factor for diseases of aging. However, little is known about the mechanisms underly-
ing the association between anxiety and ADRD risk. Moreover, the term "anxiety" is often used as an umbrella
covering multiple different categorical disorders or heterogenous symptom clusters. Overall, there is a severe
paucity of data regarding 1) the pathways through which specific anxiety phenotypes impact brain and body
aging; 2) the neurobiological markers contributing to increased ADRD risk among individuals with specific
anxiety phenotypes. A better understanding of specific neurobiological underpinning is critical to identify tar-
gets for interventions designed to prevent or limit the pernicious effect of anxiety on brain and body. Rumina-
tion, global anxiety, and worry (RAW) are three distinct and highly prevalent anxiety phenotypes, that have a
cummulative effect on chronic stress. We reported that worry and rumination (but not global anxiety) are as-
sociated with accelerated brain aging in late-life. Additional preliminary analyses indicate that worry and rumi-
nation severity are associated with other markers of brain aging such as hippocampal atrophy in subfields most
vulnerable to early AD while global anxiety is associated with regional accumulation of b amyloid in critical re-
gions such as precuneus and posterior cingulate, an association moderated by inflammatory markers. In this
proposal, we will identify the pathways through which the RAW phenotypes contribute to accelerated aging
and increased ADRD risk. We will operationalize RAW severity and examine the overall effect of RAW as well
as the individual effect of each phenotype. We will test the effect of RAW by using measures of 1) hippocampal
atrophy and glutamate excitotoxicity; 2) cerebrovascular burden; 3) plasma amyloid; 4) peripheral markers of
chronic stress [cortisol level, proinflammatory markers, carotid intima-media thickness] and 5) markers of ac-
celerated aging [senescence-associated secretory phenotype proteomic panel, telomere length and free-cell mi-
tochondrial DNA]. While continuing to follow our current cohort (N=150), we will add 150 new participants,
similarly recruited on dimensional measures of rumination, anxiety and worry. We will repeat the assessments
at two-year followup, giving us three time points for the original cohort and two time-points for the new cohort.
This study will render the largest cohort of older adults extensively characterized using clinical, neuropsycho-
logical, multimodal imaging measures as well as comprehensive measures of peripheral markers of stress and
aging. The blend of well-established and novel approaches (including computational methods and state of the
art imaging aquisitions) will allow us to frame and answer the questions imbedded in the above aims, with the
overall goal of identifying the most effective interventional and preventative targets anxious older adults.
焦虑及其障碍是心血管和心血管等几种主要衰老疾病的危险因素
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Thinking of Me or Thinking of You? Behavioral Correlates of Self vs. Other Centered Worry and Reappraisal in Late-Life.
想着我还是想你?自我的行为相关性与其他居中的忧虑和重新评估。
- DOI:10.3389/fpsyt.2022.780745
- 发表时间:2022
- 期刊:
- 影响因子:4.7
- 作者:Mizuno A;Karim HT;Newmark J;Khan F;Rosenblatt MJ;Neppach AM;Lowe M;Aizenstein HJ;Mennin DS;Andreescu C
- 通讯作者:Andreescu C
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Carmen Andreescu其他文献
Carmen Andreescu的其他文献
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{{ truncateString('Carmen Andreescu', 18)}}的其他基金
2/3: Recurrence markers, cognitive burden and neurobiological homeostasis in late-life depression (REMBRANDT)
2/3:晚年抑郁症的复发标志物、认知负担和神经生物学稳态(REMBRANDT)
- 批准号:
10308408 - 财政年份:2020
- 资助金额:
$ 151.91万 - 项目类别:
Recurrence markers, cognitive burden and neurobiological homeostasis in latelife depression (REMBRANDT) - Supplement
晚年抑郁症的复发标记、认知负担和神经生物学稳态 (REMBRANDT) - 补充
- 批准号:
10710914 - 财政年份:2020
- 资助金额:
$ 151.91万 - 项目类别:
2/3: Recurrence markers, cognitive burden and neurobiological homeostasis in late-life depression (REMBRANDT)
2/3:晚年抑郁症的复发标志物、认知负担和神经生物学稳态(REMBRANDT)
- 批准号:
10532200 - 财政年份:2020
- 资助金额:
$ 151.91万 - 项目类别:
Functional Neuroanatomy Correlates of Worry in Older Adults
功能神经解剖学与老年人担忧的相关性
- 批准号:
10397731 - 财政年份:2016
- 资助金额:
$ 151.91万 - 项目类别:
The RAW Brain - The Effect of Rumination, Anxiety and Worry on Aging and Dementia Risk
原始大脑——沉思、焦虑和担忧对衰老和痴呆风险的影响
- 批准号:
10365180 - 财政年份:2016
- 资助金额:
$ 151.91万 - 项目类别:
Functional Neuroanatomy Correlates of Worry in Older Adults
功能神经解剖学与老年人担忧的相关性
- 批准号:
9174515 - 财政年份:2016
- 资助金额:
$ 151.91万 - 项目类别:
Functional and Structural Neuroanatomy in Late-Life Generalized Anxiety Disorder
晚年广泛性焦虑症的功能和结构神经解剖学
- 批准号:
7892879 - 财政年份:2010
- 资助金额:
$ 151.91万 - 项目类别:
Functional and Structural Neuroanatomy in Late-Life Generalized Anxiety Disorder
晚年广泛性焦虑症的功能和结构神经解剖学
- 批准号:
8041007 - 财政年份:2010
- 资助金额:
$ 151.91万 - 项目类别:
Functional and Structural Neuroanatomy in Late-Life Generalized Anxiety Disorder
晚年广泛性焦虑症的功能和结构神经解剖学
- 批准号:
8213703 - 财政年份:2010
- 资助金额:
$ 151.91万 - 项目类别:
Functional and Structural Neuroanatomy in Late-Life Generalized Anxiety Disorder
晚年广泛性焦虑症的功能和结构神经解剖学
- 批准号:
8424298 - 财政年份:2010
- 资助金额:
$ 151.91万 - 项目类别:
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