Shared Resource to Investigate Cellular Metabolism

研究细胞代谢的共享资源

基本信息

批准号：
10399842
负责人：
MARK S SMELTZER
金额：
$ 18.56万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-15 至 2023-04-30
项目状态：
已结题

项目摘要

Phase II PROJECT SUMMARY/ABSTRACT Addressing infectious disease in a therapeutically relevant fashion requires an understanding of both the microbial virulence factors that contribute to the disease process and the manner in which these factors impact the host immunological and inflammatory response. Achieving this will provide an opportunity to develop novel strategies to influence the pathogen and/or host response in favor of the host, thereby providing a perfect opportunity for clinically relevant translational research. Thus, achieving this understanding continues to be the overall goal of our Center for Microbial Pathogenesis and Host Inflammatory Responses. The key element to accomplishing this is to assemble a critical mass of investigators, each under the mentorship of established senior faculty, whose research is consistent with this underlying scientific theme and the overall goals of our Center. The underlying hypothesis that ties these investigators together is that targeting diverse microbial pathogens in the context of their impact on immunological and inflammatory responses in their common human host will optimize opportunities for the elucidation of common themes with respect to the host response and its adverse consequences on the disease process. To this end, this application brings together as Project Leaders four investigators who focus on diverse microbial pathogens from the point of view of both the pathogens themselves and their impact on host inflammatory responses. To support these investigators, and to build a pipeline of new investigators whose research is consistent with our underlying scientific theme, we propose to provide an integrated and highly interactive faculty development plan for all Center investigators that leverages the resources developed during Phase I to enable our Phase II Project Leaders and other Center investigators to establish independently-funded research careers in an area consistent with this underlying theme (Aim 1); to utilize the Administrative and Scientific Development (Core A) and Research and Technical Advancement (Core B) cores developed during Phase I to continue to promote the scientific development of Center investigators and enhance the overall research infrastructure on the host campuses (Aim 2); and to build on the success of our Phase I efforts to recruit additional investigators whose research is consistent with the underlying scientific theme and promote the development of collaborative, synergistic research relationships among Center investigators (Aim 3). This will allow us to build on the success of Phase I Project Leaders to establish a self-sustaining Center for Microbial Pathogenesis and Host Inflammatory Responses.

第二阶段项目摘要/摘要以治疗相关的方式解决传染病需要了解有助于疾病过程的微生物毒力因素以及这些因素影响的方式宿主免疫和炎症反应。实现这一目标将为发展小说提供机会影响病原体和/或宿主反应以支持宿主的策略，从而提供完美临床相关转化研究的机会。因此，实现这一理解仍然是我们的微生物发病机理和宿主炎症反应中心的总体目标。关键要素实现这一目标是为了组装大量的调查人员，每个调查人员都在既定的指导下高级教师，他们的研究与这个基本的科学主题和我们的总体目标一致中心。将这些研究者联系在一起的基本假设是针对多种微生物病原体在其对共同人类的免疫学和炎症反应的影响下主机将优化阐明与主机响应及其的共同主题的机会对疾病过程的不利后果。为此，此应用程序作为项目负责人汇集了从两种病原体的角度来看，四个专注于各种微生物病原体的研究者他们自己及其对宿主炎症反应的影响。支持这些调查人员，并建立一个新调查人员的管道与我们的基本科学主题一致的研究，我们建议为所有中心调查人员提供一体综合且高度互动的教师发展计划在第一阶段开发的资源使我们的第二阶段项目领导者和其他中心调查员能够在与这个基本主题一致的领域建立独立资助的研究职业（AIM 1）；到利用行政和科学发展（核心A）以及研究与技术进步（核心）在第一阶段开发的核心继续促进中心的科学发展研究人员并增强了主机校园的总体研究基础设施（AIM 2）；并以第一阶段的成功努力招募了其他研究人员，他们的研究与基本的科学主题并促进了协作，协同研究关系的发展在中心调查人员中（AIM 3）。这将使我们能够建立I阶段项目领导者的成功建立一个自我维持的微生物发病机理和宿主炎症反应中心。