Impact of Amygdala Lateralization on Processing and Modulation of Bladder Pain

杏仁核偏侧化对膀胱疼痛处理和调节的影响

基本信息

  • 批准号:
    10399656
  • 负责人:
  • 金额:
    $ 34.43万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-08-18 至 2023-09-17
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Urologic chronic pelvic pain (UCPP) syndromes, commonly diagnosed as interstitial cystitis/bladder pain syndrome (IC/BPS) or chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), represent the most common type of chronic visceral pain disorders. Although dysregulation of peripheral inputs from the viscera likely account for a number of the symptoms of the diseases, a failure to understand and treat central nervous system (CNS) changes likely prevents complete recovery for affected patients. The long-term goal of our lab is to understand the extent to which areas in the brain are responsible for the development and maintenance of persistent pain and accompanying affective disturbances that exist within urologic conditions. We aim to discover and develop novel CNS treatment paradigms for this disease to complement approaches directed at the bladder. Recent evidence has suggested that the central amygdala in the CNS may be an important locus for the interaction between visceral pain and anxiety, potentially serving as a driver for chronic conditions like UCPP. By determining the role of the amygdala in animal models of bladder pain, insight will be provided into the underlying physiology of the human condition. Evidence from human and animal models has shown that the left and right amygdala may differentially regulate pain. Variances in left and right hemisphere activation are well described in human language production, visual processing, and complex planning tasks. [Functional lateralization exists in emotional processing areas of the brain, including the amygdala, across multiple taxa including birds and mammals where the right brain serves as a reactive center to stress and injury. This conservation suggests that lateralization of limbic circuits is likely an evolutionarily important phenomenon.] The idea that dysregulation in lateralization might also play a significant role in disease is a novel concept with important clinical relevance. UCPP patients show lateralized changes in amygdala gray matter and lateralized amygdala functional connectivity to other areas in the CNS. The molecular mediators responsible for incoming information to the left versus right amygdala remain unknown. The objective of this proposal is to determine the extent of bladder pain lateralization between the left and right central amygdalae and the molecular mechanisms responsible for this phenomenon. This objective will be met through two distinct but complementary specific aims. In Aim 1 of this proposal, we will determine the extent of left and right amygdala activation following stimulation of control or sensitized bladders, while also probing the areas of the brain through which nociceptive information travels. In Aim 2, we will manipulate specific brainstem projections to the amygdala to determine which cells are sufficient and necessary for lateralized pain-like output in both control and sensitized conditions. Overall, this proposal will help determine the extent and mechanisms of amygdala activation during painful bladder stimulation and the mechanisms by which an overactive amygdala may contribute to bladder pain as seen in UCPP.
项目总结

项目成果

期刊论文数量(0)
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专利数量(0)

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BENEDICT J KOLBER其他文献

BENEDICT J KOLBER的其他文献

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{{ truncateString('BENEDICT J KOLBER', 18)}}的其他基金

Planning Study for the Development of Sigma 2 ligands as Analgesics
Sigma 2 配体镇痛药开发规划研究
  • 批准号:
    10641500
  • 财政年份:
    2023
  • 资助金额:
    $ 34.43万
  • 项目类别:
Impact of Amygdala Lateralization on Processing and Modulation of Bladder Pain
杏仁核偏侧化对膀胱疼痛处理和调节的影响
  • 批准号:
    10248576
  • 财政年份:
    2020
  • 资助金额:
    $ 34.43万
  • 项目类别:
Impact of amygdala lateralization on processing and modulation of bladder pain
杏仁核偏侧化对膀胱疼痛处理和调节的影响
  • 批准号:
    9754129
  • 财政年份:
    2018
  • 资助金额:
    $ 34.43万
  • 项目类别:
Impact of amygdala lateralization on processing and modulation of bladder pain
杏仁核偏侧化对膀胱疼痛处理和调节的影响
  • 批准号:
    9925760
  • 财政年份:
    2018
  • 资助金额:
    $ 34.43万
  • 项目类别:
Impact of Amygdala Lateralization on Processing and Modulation of Bladder Pain
杏仁核偏侧化对膀胱疼痛处理和调节的影响
  • 批准号:
    10736493
  • 财政年份:
    2018
  • 资助金额:
    $ 34.43万
  • 项目类别:
Impact of amygdala lateralization on processing and modulation of bladder pain
杏仁核偏侧化对膀胱疼痛处理和调节的影响
  • 批准号:
    9985661
  • 财政年份:
    2018
  • 资助金额:
    $ 34.43万
  • 项目类别:
Cyanobacterial Natural Products to Treat Comorbid Pain and Depression
蓝藻天然产物可治疗共病疼痛和抑郁症
  • 批准号:
    8753582
  • 财政年份:
    2014
  • 资助金额:
    $ 34.43万
  • 项目类别:
Cellular and molecular mechanisms undelying amygdala-dependent pain modulation
杏仁核依赖性疼痛调节的细胞和分子机制
  • 批准号:
    7805233
  • 财政年份:
    2010
  • 资助金额:
    $ 34.43万
  • 项目类别:
Cellular and molecular mechanisms undelying amygdala-dependent pain modulation
杏仁核依赖性疼痛调节的细胞和分子机制
  • 批准号:
    8032461
  • 财政年份:
    2010
  • 资助金额:
    $ 34.43万
  • 项目类别:
Amygdala GR Function in Stress Activation and Promotion
杏仁核 GR 在应激激活和促进​​中的功能
  • 批准号:
    7452398
  • 财政年份:
    2006
  • 资助金额:
    $ 34.43万
  • 项目类别:

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