Interactive contouring simulation (iContour) to improve outcomes of cancer patients treated with radiation therapy

交互式轮廓模拟 (iContour) 可改善接受放射治疗的癌症患者的治疗效果

• 批准号: 10401270
• 负责人: Erin Faye Gillespie
• 金额: $ 38.33万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10401270
• 关键词: Interactive; contouring; simulation; iContour; improve

PROJECT SUMMARY/ABSTRACT Radiation therapy plays a central role in the treatment of cancer. The delivery of safe and effective radiation hinges on the ability to identify the radiation target (tumor), and areas to avoid (normal tissues). The act of defining the radiation target – referred to as contouring – requires a sound understanding of anatomy, radiology, and most importantly the individual patient. Existing research clearly shows that poor contouring leads to increased toxicity, and decreased survival, which emphasizes the importance of contouring to deliver safe and effective radiation therapy. This project proposes to create and test a simulation-based educational approach to improving contour quality in radiation oncology. This contouring simulation tool will allow radiation oncology providers the ability to contour test cases and receive rapid feedback on the accuracy of their contours. We will use knowledge-based planning to help provide feedback on the real life risks of toxicity and chances of cure had their contours been used to treat that patient. Using iterative and participatory design we will engage stakeholders to develop a comprehensive interactive web-based simulation tool (iContour), as well as a more focused mobile application (iContour-mobile). Successful educational applications require user engagement, therefore to increase user engagement we will leverage components of gamification and social media. With a randomized clinical trial we will test the efficacy of these different simulation strategies on real patient contours. Overall, this study seeks to define the optimal simulation strategy of how to improve real-world contouring. If successful this simulation-based education approach could transform contouring education and play a central role in residency education, continuing medical education, and board certification for radiation oncology, and serve as a model for developing simulation training tools for other fields in medicine.

项目摘要/摘要 放射治疗在癌症治疗中起着核心作用。安全有效辐射的交付 取决于鉴定辐射靶（肿瘤）和避免区域（正常组织）的能力。行为 定义辐射靶（称为轮廓）需要对解剖学有合理的理解， 放射学，最重要的是个体患者。现有的研究清楚地表明，轮廓差 导致毒性增加和生存增加，这强调了轮廓交付的重要性 安全有效的放射疗法。 该项目的提案旨在创建和测试基于模拟的教育方法，以提高轮廓质量 在辐射肿瘤学中。这种轮廓模拟工具将使辐射肿瘤学提供者能够 轮廓测试用例并收到有关其轮廓准确性的快速反馈。我们将使用基于知识的 计划有助于提供有关现实生活中毒性风险的反馈，并且治愈的可能性是 用于治疗该患者。使用迭代和参与设计，我们将吸引利益相关者开发一个 全面的交互式基于Web的仿真工具（ICONTOUR）以及更重点的移动应用程序 （icontour-mobile）。成功的教育应用需要用户参与，因此增加用户 参与我们将利用游戏化和社交媒体的组成部分。在随机临床试验中我们 将测试这些不同的模拟策略对实际患者轮廓的效率。总体而言，这项研究试图 定义如何改善现实世界轮廓的最佳仿真策略。 如果成功这种基于模拟的教育方法可以改变轮廓教育并发挥作用 在居住教育，持续医学教育和辐射董事会认证中的中心作用 肿瘤学，并作为开发用于其他医学领域的模拟培训工具的模型。