Bio Science Facility Core

生物科学设施核心

• 批准号: 10400885
• 负责人: ROBERT C BURGHARDT
• 金额: $ 5.29万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400885
• 关键词: 3-Dimensional; Animals; Back; Bioinformatics; Biological; Biometry; Cells; Collaborations; Communities; Consult; Core Facility; Cultured Cells; Data Science; Data Set; Development; Disease; Doctor of Philosophy; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Risk Factor; Equipment; Functional Imaging; Generations; Genes; Genetic Determinism; Goals; Health; Health Sciences; Human; Human Resources; Image; Imaging technology; In Vitro; Information Retrieval; Infrastructure; Interdisciplinary Study; Investments; Link; Measures; Mentors; Modeling; Molecular; Nature; Organoids; Pattern; Phenotype; Physiological; Physiology; Population; Positioning Attribute; Predisposition; Procedures; Public Health; Research; Research Activity; Research Personnel; Resources; Risk; Science; Services; Specialist; System; Target Populations; Technology; Texas; Tissues; Toxic effect; Toxicology; Training; Translating; Translational Research; Translations; Vision; community engagement; cost effective; data management; data mining; data sharing; design; experience; in vivo; in vivo Model; indexing; innovation; insight; instrumentation; member; metabolic phenotype; molecular phenotype; novel; organ on a chip; testing access

Bio Science Facility Core (BSFC) ABSTRACT A major goal of the Texas A&M Center for Environmental Health Research (TiCER) is to evaluate the effects of toxicological agents present in the environment on target populations. The ability to quantify biological effects of different exposures is critical to understanding and interpreting the health impact of environmental exposures. The Bio Science Facility Core (BSFC) will provide Center members access to key enabling technologies and expertise to support the vision of the Center “Enhancing Public Health by Identifying, Understanding and Reducing Adverse Environmental Health Risks.” This will be accomplished by providing access to state-of-the- art analytical technology, infrastructure, and expertise to perform mechanistic research on environmental factors that impact human health and disease. The BSFC will integrate imaging, molecular, and physiological phenotyping capabilities, which are currently distributed across the Texas A&M campus, to support multi-scale research into the underlying mechanisms of environmental health risks, from single cells and organoids to experimental animal populations. The BSFC will achieve this goal by: (1) Maintaining a wide range of state-of- the-art technologies and expertise to enhance environmental health research integration and translation; (2) Providing subsidized and prioritized access to expertise with analytical technologies through training, consulting services, applications development, and mentoring; and (3) Facilitating translational research activities to enhance the capacity, breadth, collaborative nature, and impact of environmental health research. The BSFC will provide expertise and analytical equipment to measure a continuum of phenotypic readouts ranging from the single-cell level to population-scale models. The leaders of the BSFC have an established track record of collaborative, interdisciplinary, and translational research, and are well positioned to facilitate the technology needs of Center members to increase research efficiency and facilitate sharing of experimental procedures.

生物科学设施核心（BSFC）摘要 德克萨斯A&M环境健康研究中心（TiCER）的一个主要目标是评估 环境中存在的毒物对目标人群的影响。量化生物效应的能力 对不同暴露的认识对于理解和解释环境暴露对健康的影响至关重要。 生物科学设施核心（BSFC）将为中心成员提供关键技术， 专业知识，以支持该中心的愿景“通过识别，理解和 减少有害环境健康风险。这将通过提供进入国家的机会来实现。 艺术分析技术，基础设施和专业知识，对环境因素进行机械研究 影响人类健康和疾病。BSFC将整合成像，分子和生理 表型分析能力，目前分布在整个德州A&M校园，以支持多尺度 研究环境健康风险的潜在机制，从单细胞和类器官到 实验动物种群。BSFC将通过以下方式实现这一目标：（1）保持广泛的状态- 最先进的技术和专业知识，以加强环境健康研究的整合和翻译;（2） 通过培训、咨询和培训， 服务、应用程序开发和指导;以及（3）促进转化研究活动， 提高环境卫生研究的能力、广度、协作性和影响。述制动特定燃料消耗 将提供专业知识和分析设备，以衡量一个连续的表型读数，从 单细胞水平到群体规模模型。BSFC的领导人有一个既定的记录， 合作，跨学科和转化研究，并处于有利地位，以促进技术 中心成员的需求，以提高研究效率和促进共享实验程序。