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Integrative Health Sciences Facility Core

综合健康科学设施核心

基本信息

批准号：
10400882
负责人：
Ivan Rusyn
金额：
$ 22.1万
依托单位：
TEXAS A&M UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10400882
关键词：
3-Dimensional Address Affect Amendment Animal Model Animals Area Basic Science Biological Models Cells Center for Translational Science Activities Chemical Exposure Clinical Communities Consult Consultations Core Facility County Data Databases Disease Disease susceptibility Doctor of Philosophy Early Diagnosis Early treatment Engineering Ensure Environmental Health Epidemiologist Epidemiology Equipment Exposure to Familiarity Fostering Funding Genes Goals Health Health Sciences Human Human Resources IACUC Ii-Key In Vitro Institutional Review Boards Integrative Medicine Interdisciplinary Study International Intervention Studies Knock-out Milieu Therapy Mission Modeling Mus National Institute of Environmental Health Sciences Organoids Personnel Staffing Pilot Projects Population Positioning Attribute Prevention Procedures Protocols documentation Public Health Research Research Design Research Personnel Research Project Grants Research Support Resources Risk Role Science Scientist Services Structure System Technology Texas Tissue Microarray Toxicology Transgenic Model Transgenic Organisms Translational Research Universities Work authority base cohort community based research community engagement epidemiology study experience experimental study human capital human disease improved in vitro Model instrumentation meetings member novel operation outreach population based population health programs public health research research facility stem cells tissue culture tool translational study voucher

项目摘要

Integrative Health Sciences Facility Core (IHSFC) ABSTRACT The Texas A&M Center for Environmental Health Research (TiCER) is focused on “Enhancing Public Health by Identifying, Understanding and Reducing Adverse Environmental Health Risks.” The IHSFC will be the major driver to fulfill the mission of the Center: to identify and address environmental health concerns through multidisciplinary collaborations among Center members and other stakeholders. IHSFC fulfills the mandate for the Environmental Health Sciences Core Centers to provide “facilities and resources to accelerate research along the spectrum from basic mechanistic and toxicological science to population and public health and dissemination.” The goal of IHSFC is to facilitate bi-directional translational studies ranging from research in the community-based human cohorts, to population-based experimental studies in mice and human cells, to microphysiological in vitro systems. This goal will be accomplished by integrating the Center’s translational research into causes and mechanisms of environmental health risks among three major areas of inquiry: (i) human community-based translational studies and databases, (ii) mouse population-based and transgenic models, and (iii) novel in vitro models. The IHSFC will be led by Dr. Ivan Rusyn, an expert in all three areas of inquiry. The human translational studies area, led by Dr. Natalie Johnson, will focus on facilitating community oriented research projects, enabling access to health and environmental information- containing databases, and consulting on IRB compliance. The mouse translational studies area, led by Dr. Ben Morpurgo, will focus on study designs and access to Collaborative Cross and RIX mouse populations, transgenic/knockout services (including CRISPR/Cas9), and IACUC compliance. The in vitro translational studies area, led by Dr. Ivan Rusyn, will focus on the use of novel microphysiological (human and mouse organoids, stem cells, and tissue chips), and population-based in vitro tools, as well as advising on biosafety compliance. The IHSFC will enable center members’ integrative research through dedicated staff in each area and a voucher-based model. The Core will provide up to $100,000 per year (½ from NIEHS and ½ from Texas A&M) to facilitate Center members’ access to and use of translational resources. The IHSFC function will include (i) close integration with the Pilot Projects Program, the Community Engagement Core, and research facility cores through monthly meetings to identify and promote integrative and translational projects, and (ii) key personnel and staff outreach to Center members to encourage and initiate projects. The IHSFC will work closely with the Administrative Core to track the Core’s operation and funding allocations and with the Pilot Projects Core to identify projects that may benefit from IHSFC expertise, equipment and resources. The IHSFC leaders have an established record of accomplishment in collaborative research among themselves and with many Center members and IHSFC is well positioned to enhance translational research bi-directionally along the spectrum from basic to community-based research to address public health challenges.

综合健康科学设施核心(IHSFC