Project 4
项目4
基本信息
- 批准号:10349754
- 负责人:
- 金额:$ 20.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-20 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAnalytical ChemistryArtsBiologicalBiological AvailabilityBiological ModelsBiomedical EngineeringCardiac MyocytesCase StudyCell LineCellsChemicalsCommunitiesComplexComputer ModelsConsumptionDataData AnalysesDisastersDoseEmergency SituationEnvironmental ExposureEnvironmental HazardsEnvironmental MonitoringEquipmentEthnic OriginEvaluationEventExposure toFundingFutureGenomeGoalsGovernmentHazardous SubstancesHealthHealth HazardsHumanImageIn VitroIndividualInternationalKnowledgeLifeMetabolismMethodologyMethodsModelingMolecularMusOptimum PopulationsOutcomePersonsPhysiologicalPopulationPopulation SizesRaceRenal clearance functionReproducibilityResearchResourcesRiskRisk AssessmentSafetySamplingScienceSiteSourceSpecificityStudy modelsSuperfundSystemTechniquesTestingTexasTimeTissue MicroarrayTissuesToxic effectToxicokineticsTranslational ResearchTranslationsUniversitiesWorkbasecommunity engagementdata managementdesigndetection methodevidence baseexperimental studyfirst responderhazardhealth assessmenthigh dimensionalityhigh throughput screeninghuman modelin vitro Modelin vivoin vivo evaluationinduced pluripotent stem cellinter-individual variationliver metabolismlymphoblastman-made disastersnovelnovel strategiesorgan on a chippopulation basedresponsesexsuperfund sitetooltool development
项目摘要
Project 4 ABSTRACT
Project 4 aims to develop a translational in vitro-to-in vivo testing strategy for evaluating the inter-tissue and inter-
individual variability in responses to complex environmental exposures. This goal is a critical part of the overall
strategy of the Texas A&M University Superfund Research Center to characterize and manage the human health
risks associated with exposure to environmental emergency-mobilized hazardous substances through the
development of tools that can be used by first responders, the impacted communities, and the government
bodies involved in site management and cleanup. In the past funding period, we not only developed a multi-
tissue “biological read-across” approach for complex environmental exposures in high-content/high-throughput
assays using human induced pluripotent stem cells (iPSC), but also demonstrated its utility for quantitative
estimation of hazard of complex environmental exposures through a number of case studies that spanned
community, national and international scales. These studies show how new approach methodologies (NAMs)
can be applied for assessment of risks from real-life exposures. Our central hypothesis remains that a tiered
risk-based strategy for safety evaluation utilizing human organotypic in vitro cultures, combined with population-
based reverse toxicokinetics, can be used to accurately characterize the risks posed by combined exposures to
hazardous substances during environmental emergencies. First, we will develop a population-based human in
vitro approach to characterize inter-tissue and inter-individual variability in responses to complex environmental
exposures. We will test the hypothesis that human population-based in vitro models can refine hazard predictions
and characterize the molecular underpinnings and extent of inter-tissue and inter-individual variability. Second,
we will develop a high-throughput reverse toxicokinetics (RTK) modeling approach for complex exposures to
enable in vitro-to-in vivo extrapolation (IVIVE) of environmental samples. Because IVIVE is critical for
interpretation of in vitro NAMs data in the context of human health, we hypothesize that novel exposomic
analyses and new organ-on-a-chip models can provide concentration- and combined exposure-dependent RTK
parameters needed for IVIVE, ultimately enabling more accurate predictions of effects in vivo. Third, as art of
Center’s Disaster Research Response (DR2) approach, we will demonstrate the application of human multi-
tissue and population-wide high-throughput in vitro models to disaster research response. We will show how the
“biological read-across” method developed in the past funding period can be applied to DR2 by testing the
hypothesis that in vitro toxicity data can be used to quantitatively predict and characterize health hazard of
environmental samples. We will partner with all Projects to use their samples or collaborate on analytical,
molecular and biomedical engineering methods and techniques. We will work with all Cores for data analysis
and management, geospatial analysis, and translation of our research to the impacted communities and other
stakeholders. The data and methods from this project will be of critical importance in responses to disasters.
项目四
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Ivan Rusyn其他文献
Ivan Rusyn的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Ivan Rusyn', 18)}}的其他基金
Comprehensive tools and models for addressing exposure to mixtures during environmental emergency-related contamination events
用于解决环境紧急事件相关污染事件期间混合物暴露问题的综合工具和模型
- 批准号:
10349750 - 财政年份:2022
- 资助金额:
$ 20.3万 - 项目类别:
Comprehensive tools and models for addressing exposure to mixtures during environmental emergency-related contamination events
用于解决环境紧急事件相关污染事件期间混合物暴露问题的综合工具和模型
- 批准号:
10707432 - 财政年份:2022
- 资助金额:
$ 20.3万 - 项目类别:
Chromatin regions, genes and pathways that confer susceptibility to chemical-induced DNA damage
导致对化学诱导的 DNA 损伤易感性的染色质区域、基因和途径
- 批准号:
10330422 - 财政年份:2019
- 资助金额:
$ 20.3万 - 项目类别:
Chromatin regions, genes and pathways that confer susceptibility to chemical-induced DNA damage
导致对化学诱导的 DNA 损伤易感性的染色质区域、基因和途径
- 批准号:
10091978 - 财政年份:2019
- 资助金额:
$ 20.3万 - 项目类别:
Chromatin regions, genes and pathways that confer susceptibility to chemical-induced DNA damage
导致对化学诱导的 DNA 损伤易感性的染色质区域、基因和途径
- 批准号:
10559536 - 财政年份:2019
- 资助金额:
$ 20.3万 - 项目类别:
相似海外基金
Aquatic Analytical Chemistry
水生分析化学
- 批准号:
CRC-2018-00279 - 财政年份:2022
- 资助金额:
$ 20.3万 - 项目类别:
Canada Research Chairs
Spatially Resolved Analytical Chemistry: Magnetic Resonance and Magnetic Resonance Imaging of Materials and Processes.
空间分辨分析化学:材料和过程的磁共振和磁共振成像。
- 批准号:
RGPIN-2022-04003 - 财政年份:2022
- 资助金额:
$ 20.3万 - 项目类别:
Discovery Grants Program - Individual
Analytical Chemistry of Proteins and Peptides
蛋白质和肽的分析化学
- 批准号:
RGPIN-2020-04677 - 财政年份:2022
- 资助金额:
$ 20.3万 - 项目类别:
Discovery Grants Program - Individual
Spatially Resolved Analytical Chemistry - Magnetic Resonance Imaging of Materials
空间分辨分析化学 - 材料的磁共振成像
- 批准号:
RGPIN-2015-06122 - 财政年份:2021
- 资助金额:
$ 20.3万 - 项目类别:
Discovery Grants Program - Individual
Aquatic Analytical Chemistry
水生分析化学
- 批准号:
CRC-2018-00279 - 财政年份:2021
- 资助金额:
$ 20.3万 - 项目类别:
Canada Research Chairs
Droplet-Based Analytical Chemistry Platforms Using Superhydrophobic and Superamphiphobic Surfaces
使用超疏水和超双疏表面的基于液滴的分析化学平台
- 批准号:
RGPIN-2016-04790 - 财政年份:2021
- 资助金额:
$ 20.3万 - 项目类别:
Discovery Grants Program - Individual
Analytical Chemistry of Proteins and Peptides
蛋白质和肽的分析化学
- 批准号:
RGPIN-2020-04677 - 财政年份:2021
- 资助金额:
$ 20.3万 - 项目类别:
Discovery Grants Program - Individual