NOSI to Support Enhancement of Software Tools for Multilevel Mediation Analysis for Investigating Effects of Environmental and Individual Risk Factors on Respiratory Diseases
NOSI 支持增强多级中介分析软件工具,以调查环境和个人风险因素对呼吸道疾病的影响
基本信息
- 批准号:10403859
- 负责人:
- 金额:$ 22.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-02 至 2022-01-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptionAffectAir PollutantsAlgorithmic SoftwareAustraliaBehavioralBig DataBirthCategoriesChemicalsChildCloud ComputingCodeCommunitiesComplexComputer softwareComputersDataData AnalysesData SetDropsEngineeringEnvironmentExposure toFire - disastersFree RadicalsGeographic LocationsGraphHazardous Waste SitesHealthHouse DustIndividualInternetInterventionIntuitionKnowledgeLanguageLifeLinkLiteratureLung diseasesMeasuresMediatingMediationMediator of activation proteinMethodsModelingOutcomeParticulate MatterPathway interactionsPerformancePolicy MakerPopulationQuality of lifeQueenslandR programming languageResearchResearch PersonnelResourcesRisk FactorsScienceScientific InquiryScientistSoftware EngineeringSoftware ToolsSourceSpeedStatistical MethodsStephaniaStructureSuperfundTaxesTechniquesTechnologyTestingUniversitiesVisualWritingbasecloud basedcohortcomputing resourcesdata managementdata miningdesignexperiencehealth disparityimprovednovelparallel computerpredictive modelingprogramsprospectivepulmonary functionrespiratoryrespiratory healthskillssoftware developmenttoolusability
项目摘要
Multilevel Mediation Analysis for Investigating Effects of Environmental and Individual
Risk Factors on Respiratory Diseases
The link between particulate matter (PM) exposure and poor respiratory health is well
established. Through Aim 3 of Project 1, the LSU Superfund Research Center postulates that
environmentally persistent free radicals (EPFRs) from hazardous waste sites,
incinerators/chemical fires, and other sources is the missing mechanistic link between PM
exposure and poor respiratory health. We will investigate the mediation of this association using
hierarchical mediation analysis to decompose the air pollutant adverse respiratory effects into
direct and indirect (EPFR-mediated) effects.
We developed a multilevel mediation analysis method that allows for both longitudinal
assessments of residential environments and individual risk factors to be jointly utilized in
determining the mechanistic link between exposure to PM and poor respiratory health. By
including measures of individual behavioral factors our methods are capable of explaining
existing disparities in health outcomes.
We have implemented our method as an R package (mlma) to provide the research community
with open access to software for performing multilevel hierarchical mediation analysis. However,
use of our R package does require knowledge of R, which limits its broader use in research. To
address this limitation, we propose to collaborate with a software engineer at LSU to create an
API for an interactive web implementation of our mediation software. We expect that this would
greatly expand access to our methods, as no programming will be required. The proposed app,
with its intuitive interactive visual interface, will allow users to easily read in datasets and build a
conceptual mediation model framework using drag-and-drop functionality. We will also provide
graphical tools such as directed acyclic graphs to allow users to visually interpret the analysis
results. In addition, we will transform part of the computing to an efficient low-level computer
language to improve computational speed and plan to use cloud computing resources so that R
and associated software packages do not have to be installed on individual computers to
perform the analysis.
环境和个人影响调查的多水平中介分析
呼吸系统疾病的危险因素
暴露在颗粒物(PM)和不良的呼吸道健康之间有很好的联系
已经成立了。通过项目1的目标3,路易斯安那州立大学超级基金研究中心假设
来自危险废物场地的环境持久性自由基(EPFR),
焚烧炉/化学火灾和其他来源是PM之间缺失的机械联系
暴露和呼吸健康状况不佳。我们将调查该协会的调解使用
层次化中介分析将大气污染物对呼吸道的不良影响分解为
直接和间接(EPFR介导的)影响。
我们开发了一种多层次的中介分析方法,允许纵向
共同利用的居住环境和个人风险因素评估
确定暴露在PM和呼吸健康不良之间的机械联系。通过
包括对个体行为因素的衡量,我们的方法能够解释
在健康结果方面存在差异。
我们以R包(MLMA)的形式实现了我们的方法,以向研究社区提供
开放访问用于执行多级分层调解分析的软件。然而,
使用我们的R包确实需要了解R,这限制了它在研究中的更广泛使用。至
针对这一限制,我们建议与路易斯安那州立大学的一名软件工程师合作,创建一个
用于我们的调解软件的交互式Web实施的API。我们预计这将是
极大地扩展了对我们方法的访问,因为不需要编程。拟议中的应用程序,
凭借其直观的交互式可视化界面,将允许用户轻松读取数据集并构建
使用拖放功能的概念性调解模型框架。我们还将提供
图形工具,如有向无环图,允许用户直观地解释分析
结果。此外,我们还将把部分计算转换为高效的低级计算机
语言,以提高计算速度,并计划使用云计算资源,使R
和相关联的软件包不必安装在单独的计算机上
执行分析。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Stephania A Cormier其他文献
Innate IL-13 in virus-induced asthma?
病毒诱导的哮喘中先天的白细胞介素-13 吗?
- DOI:
10.1038/ni.2056 - 发表时间:
2011-06-20 - 期刊:
- 影响因子:27.600
- 作者:
Stephania A Cormier;Jay K Kolls - 通讯作者:
Jay K Kolls
Th2 mediated pulmonary inflammation induces the differential expression of a unique eosinophil-associated ribonuclease gene
- DOI:
10.1016/s0091-6749(02)81628-1 - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
Stephania A Cormier;Shubing Yuang;Dawn Dimina;Nancy A Lee;James J Lee - 通讯作者:
James J Lee
Stephania A Cormier的其他文献
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{{ truncateString('Stephania A Cormier', 18)}}的其他基金
2023 Focus Meeting of the Pacific Basin Consortium for Environment and Health
2023年太平洋盆地环境与健康联盟焦点会议
- 批准号:
10753652 - 财政年份:2023
- 资助金额:
$ 22.7万 - 项目类别:
KC Donnelly Externship - LSU SRP MATHIEU: AERMOD spatial predictive model for airborne exposure to PCBs
KC Donnelly Externship - LSU SRP MATHIEU:空气中 PCB 暴露的 AERMOD 空间预测模型
- 批准号:
10580929 - 财政年份:2022
- 资助金额:
$ 22.7万 - 项目类别:
19th International Conference of the Pacific Basin Consortium for Environment and Health
第十九届太平洋盆地环境与健康联盟国际会议
- 批准号:
10469074 - 财政年份:2022
- 资助金额:
$ 22.7万 - 项目类别:
2022 Biology of Acute Respiratory Infection GRC / GRS
2022 急性呼吸道感染生物学 GRC / GRS
- 批准号:
10388659 - 财政年份:2022
- 资助金额:
$ 22.7万 - 项目类别:
Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)
促进健康相关研究多样性的研究补充(管理补充 - 不允许进行临床试验)
- 批准号:
10400398 - 财政年份:2021
- 资助金额:
$ 22.7万 - 项目类别:
Environmental Health in a Changing Climate: the 19th International Conference of the Pacific Basin Consortium for Environment and Health
气候变化中的环境健康:第十九届太平洋盆地环境与健康联盟国际会议
- 批准号:
10307011 - 财政年份:2021
- 资助金额:
$ 22.7万 - 项目类别:
LSU Superfund Research Center - Environmentally Persistent Free Radicals
路易斯安那州立大学超级基金研究中心 - 环境持久性自由基
- 批准号:
10770302 - 财政年份:2021
- 资助金额:
$ 22.7万 - 项目类别:
LSU Superfund Research Center - Environmentally Persistent Free Radicals
路易斯安那州立大学超级基金研究中心 - 环境持久性自由基
- 批准号:
10575424 - 财政年份:2021
- 资助金额:
$ 22.7万 - 项目类别:
14th International Congress on Combustion By-Products and Their Health Effects
第十四届国际燃烧副产品及其健康影响大会
- 批准号:
8837868 - 财政年份:2014
- 资助金额:
$ 22.7万 - 项目类别:
The Role of IL4R Alpha in Neonatal RSV Immunopathology
IL4R Alpha 在新生儿 RSV 免疫病理学中的作用
- 批准号:
8701225 - 财政年份:2011
- 资助金额:
$ 22.7万 - 项目类别:
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