Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)

促进健康相关研究多样性的研究补充（管理补充 - 不允许进行临床试验）

• 批准号: 10400398
• 负责人: Stephania A Cormier
• 金额: $ 2.92万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-22 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400398
• 关键词: Address; Biological; Biomedical Research; Chemicals; Clinical Trials; Data; Exposure to; Free Radical Formation; Free Radicals; Goals; Grant; Health; Human; Laboratories; Laccase; Lung; Mentors; Methodology; Methods; Myron; National Institute of Environmental Health Sciences; Nature; Oxidation-Reduction; Prevention; Reproducibility; Research; Research Project Grants; STEM field; Soil; Superfund; System; Training; Training Activity; Underrepresented Minority; Work; Writing; advanced analytics; analytical method; base; cardiovascular health; career development; data sharing; lard; recruit; remediation; response; responsible research conduct; skills

Project Summary/Abstract The evidence is strong that underrepresentation of minorities in the STEM fields is a critical issue that needs to be addressed. One of the objectives of this proposal is to recruit, support, and mentor a trainee, Mr. Myron Lard, from an underrepresented background, for Project 5 of LSU Superfund Research Center – Environmentally Persistent Free Radicals (NIEHS grant #2-P42ES013648-09) through a research supplement to promote diversity in health-related research (following PA-21-071). The aim of the research at the LSU Center is to understand how environmentally persistent free radicals (EPFRs) are formed and how they impact pulmonary and cardiovascular health, as well as to develop prevention, remediation, and human health protective strategies based on fundamental physical, chemical, and biological understanding, with Project 5 focusing on the fundamental physical and chemical understanding. The project can be viewed as two components. The first component is the scientific research in which laboratory-generated EPFR systems, mimicking EPFR-containing soils, will be studied to determine if 1) EPFR formation by multiple redox centers is additive and 2) biological inputs, such as laccase, induce further EPFR formation beyond that seen in abiotic systems. The laboratory-generated EPFRs will then be studied by advanced analytical methods to gain an atomic-level understanding of EPFR formation and the nature of the formed EPFRs. Subsequently, and in conjunction with Projects 1 and 2, biological exposure to the laboratory-generated EPFRs will be performed, with the main goal of using atomic-level information to predict the nature and magnitude of the biological responses to these EPFRs. In addition to the experimental training, in the second component of this project, Mr. Lard will be mentored in scientific research presentation skills, new methodologies, methods for enhancing rigor and the reproducibility of data as well as data sharing, the Responsible Conduct of Research, grant writing, and career development. When combined, these training activities will enhance Myron's research capabilities, particularly in the field of biomedical research.

项目摘要/摘要 强有力的证据表明，在STEM领域，少数族裔代表不足是一种 需要解决的关键问题。这项提案的目标之一是 招募、支持和指导实习生Myron Lard先生 路易斯安那州立大学超级基金研究中心项目5-环境背景 持久性自由基(NIEHS授权#2-P42ES013648-09) 补充资料，以促进健康相关研究的多样性(遵循PA-21-071)。这个 路易斯安那州立大学中心的研究目的是了解环境可持续性 自由基(EPFR)的形成及其对肺和心血管的影响 健康，以及制定预防、补救和人类健康保护 基于对物理、化学和生物的基本了解的战略， 项目5侧重于对基本的物理和化学的理解。该项目 可以被视为两个组成部分。第一个组成部分是科学研究，其中 实验室产生的EPFR系统，模拟含有EPFR的土壤，将被研究以 确定1)多个氧化还原中心形成EPFR是否是相加的，以及2)生物是否 输入，如漆酶，会进一步诱导EPFR的形成，而不是非生物 系统。然后对实验室产生的EPFR进行高级分析研究 从原子水平上了解EPFR的形成和性质的方法 形成EPFR。随后，结合项目1和2，生物 将进行实验室产生的EPFR的暴露，主要目标是 利用原子级信息来预测生物的性质和大小 对这些EPFR的响应。除了实验训练，在第二次 作为该项目的组成部分，Lard先生将在科学研究演示文稿中接受指导 提高数据的严密性和再现性的技能、新方法和方法 以及数据共享、负责任的研究、拨款撰写和职业生涯 发展。当这些培训活动结合在一起时，将加强Myron的研究 能力，特别是在生物医学研究领域。