Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)

项目总结/摘要 有证据表明，少数民族在STEM领域的代表性不足是一个严重的问题。 需要解决的关键问题。这项建议的目标之一是 招聘，支持，并指导一个实习生，迈伦拉德先生，从一个代表性不足的 背景，路易斯安那州立大学超级基金研究中心项目5-环境 持久性自由基（NIEHS资助#2-P42 ES 013648 -09） 促进健康相关研究多样性的补充文件（遵照PA-21-071）。的 路易斯安那州立大学中心的研究目的是了解环境如何持久 自由基（EPFR）的形成以及它们如何影响肺和心血管 健康，以及制定预防，补救和人类健康的保护 基于基本的物理，化学和生物学理解的战略， 项目5侧重于基本的物理和化学理解。项目 可以看作是两个部分。第一部分是科学研究， 将研究模拟含EPFR土壤的实验室生成的EPFR系统， 确定1）多个氧化还原中心的EPFR形成是否是相加的，以及2）生物学的 输入，如漆酶，诱导进一步的EPFR形成超出了非生物中所见的 系统.实验室产生的EPFR将通过先进的分析方法进行研究。 方法来获得一个原子级的理解EPFR的形成和性质， 形成EPFR。随后，结合项目1和2， 将进行实验室产生的EPFR暴露，主要目标是 使用原子级信息来预测生物的性质和大小， 对这些EPFR的反应。除了实验训练，在第二次 作为该项目的一部分，Lard先生将在科学研究报告中接受指导。 技能，新的方法，提高数据的严谨性和再现性的方法， 以及数据共享，负责任的研究行为，资助写作和职业生涯 发展当这些培训活动结合起来时， 能力，特别是在生物医学研究领域。

Project Summary/Abstract The evidence is strong that underrepresentation of minorities in the STEM fields is a critical issue that needs to be addressed. One of the objectives of this proposal is to recruit, support, and mentor a trainee, Mr. Myron Lard, from an underrepresented background, for Project 5 of LSU Superfund Research Center – Environmentally Persistent Free Radicals (NIEHS grant #2-P42ES013648-09) through a research supplement to promote diversity in health-related research (following PA-21-071). The aim of the research at the LSU Center is to understand how environmentally persistent free radicals (EPFRs) are formed and how they impact pulmonary and cardiovascular health, as well as to develop prevention, remediation, and human health protective strategies based on fundamental physical, chemical, and biological understanding, with Project 5 focusing on the fundamental physical and chemical understanding. The project can be viewed as two components. The first component is the scientific research in which laboratory-generated EPFR systems, mimicking EPFR-containing soils, will be studied to determine if 1) EPFR formation by multiple redox centers is additive and 2) biological inputs, such as laccase, induce further EPFR formation beyond that seen in abiotic systems. The laboratory-generated EPFRs will then be studied by advanced analytical methods to gain an atomic-level understanding of EPFR formation and the nature of the formed EPFRs. Subsequently, and in conjunction with Projects 1 and 2, biological exposure to the laboratory-generated EPFRs will be performed, with the main goal of using atomic-level information to predict the nature and magnitude of the biological responses to these EPFRs. In addition to the experimental training, in the second component of this project, Mr. Lard will be mentored in scientific research presentation skills, new methodologies, methods for enhancing rigor and the reproducibility of data as well as data sharing, the Responsible Conduct of Research, grant writing, and career development. When combined, these training activities will enhance Myron's research capabilities, particularly in the field of biomedical research.