Cortical Circuit Basis of Visual Spatial Processing

视觉空间处理的皮层回路基础

• 批准号: 8968551
• 负责人: CHRISTOS CONSTANTINIDIS
• 金额: $ 38.44万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2018-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8968551
• 关键词: Address; Affect; Animals; Area; Behavior; Behavioral; Brain; Brain Diseases; Brain Injuries; Cerebral cortex; Cognitive deficits; Cues; Disease; Dorsal; Elements; Exposure to; Faculty; Functional Magnetic Resonance Imaging; Goals; Grant; Human; Image; Individual; Judgment; Learning; Lesion; Location; Maintenance; Measures; Mediating; Memory; Mental disorders; Modeling; Monkeys; Motor; Nature; Neurobiology; Neurons; Neurosciences Research; Outcome; Output; Parietal; Parietal Lobe; Pathway interactions; Pattern; Performance; Plastics; Play; Population; Prefrontal Cortex; Probability; Process; Property; Psyche structure; Reporting; Research; Role; Short-Term Memory; Signal Transduction; Source; Staging; Stimulus; Testing; Training; Visual; Visuospatial; base; cognitive ability; cognitive function; cognitive process; cognitive task; driving behavior; functional plasticity; neural circuit; neural correlate; neurophysiology; nonhuman primate; operation; public health relevance; research study; response; visual stimulus

 DESCRIPTION (provided by applicant): Explicating the neurobiological basis of cognitive functions such as visual short term memory has been a long standing goal of scientific research because it is essential for understanding normal cognitive functions and treating brain disorders that can devastate the ability to think and act. The proposed experiments will investigate the role of two brain areas, the posterior parietal and the dorsolateral prefrontal cortex in cognitive functions, relying on a non-human primate model. We will comparatively investigate the single-neuron and population responses in these two areas, with respect to visual short-term memory capacity, the influence of each brain area to memory involved behavior, and their functional plasticity as a result of training in short term memory tasks. These studies will help unveil the functional specialization of cortical areas involved in higher cognitive functions and offer insighs on normal cognitive processing as well as the consequences of brain injury and mental illness.

 描述（由申请人提供）：阐明认知功能（如视觉短期记忆）的神经生物学基础一直是科学研究的长期目标，因为它对于理解正常认知功能和治疗可能损害思考和行动能力的大脑疾病至关重要。拟议的实验将调查的作用 两个大脑区域，后顶叶和背外侧前额叶皮层的认知功能，依赖于非人类灵长类动物模型。我们将比较研究这两个脑区的单神经元反应和群体反应，包括视觉短时记忆容量、各脑区对记忆相关行为的影响以及短时记忆任务训练后的功能可塑性。这些研究将有助于揭示涉及高级认知功能的皮层区域的功能特化，并提供关于正常认知过程以及脑损伤和精神疾病后果的见解。