Induction of lupus-related autoantibodies by TNF inhibitors

摘要 该提案旨在测试关于多系统炎症综合征的两个假设 （MIS-C）最近在感染SARS-CoV-2的儿童和年轻人中发现。我们 假设存在从严重急性疾病到MIS-C疾病谱。严重 Cov急性疾病与干扰素产生低，病毒控制差和 免疫中心产生的抗体反应，导致长期免疫，而MIS- C与高干扰素相关，有效控制病毒，但卵泡外衍生 长期免疫力差的抗体反应。我们将通过一个基因测试来验证这一假设。 分析、血清细胞因子分析和抗病毒抗体分析。我们还假设 MIS-C受试者的血浆代谢谱可预测短期心功能不全 以及长期的心脏损伤

Abstract This proposal seeks to test two hypotheses regarding the Multisystem Inflammatory Syndrome (MIS-C) recently identified in children and young adults infected with SARS-CoV-2. We hypothesize that there is a spectrum of disease from severe acute disease to MIS-C. Severe Cov acute disease is associated with low interferon production, poor control of virus and a germinal center derived antibody response to the virus leading to long term immunity while MIS- C is associated with high interferon, efficient control of virus, but an extrafollicular derived antibody response with poor long term immunity. We will test this hypothesis through a genetic analysis, analysis of serum cytokines and analysis of anti-viral antibodies. We also hypothesize that plasma metabolic profile of subjects with MIS-C will predict short term cardiac dysfunction and long term cardiac damage.