Induction of lupus-related autoantibodies by TNF inhibitors

摘要 这项提议试图检验关于多系统炎症综合症的两个假说 最近在感染SARS-CoV-2的儿童和年轻人中发现了(mis-C)。我们 假设有一系列疾病，从严重的急性疾病到MIS-C。严重者 冠状病毒急性疾病与干扰素产量低，病毒控制不力，以及 生发中心对病毒产生抗体反应，导致长期免疫，而MIS. C与高干扰素有关，有效控制病毒，但卵泡外衍生 长期免疫力差的抗体反应。我们将通过一种基因来检验这一假设 分析、分析血清细胞因子和分析抗病毒抗体。我们还假设 MI-C受试者的血浆代谢谱可预测短期心功能不全 和长期的心脏损伤。

Abstract This proposal seeks to test two hypotheses regarding the Multisystem Inflammatory Syndrome (MIS-C) recently identified in children and young adults infected with SARS-CoV-2. We hypothesize that there is a spectrum of disease from severe acute disease to MIS-C. Severe Cov acute disease is associated with low interferon production, poor control of virus and a germinal center derived antibody response to the virus leading to long term immunity while MIS- C is associated with high interferon, efficient control of virus, but an extrafollicular derived antibody response with poor long term immunity. We will test this hypothesis through a genetic analysis, analysis of serum cytokines and analysis of anti-viral antibodies. We also hypothesize that plasma metabolic profile of subjects with MIS-C will predict short term cardiac dysfunction and long term cardiac damage.