T32 Training Grant in Translational Immunology

T32 转化免疫学培训补助金

• 批准号: 10653079
• 负责人: Anne Davidson
• 金额: $ 27.69万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10653079
• 关键词: Grant; Training; translational immunology

This new T32 program is designed to provide a rigorous training program in translational immunology for 2 pre-doctoral and one post-doctoral candidate. It will recruit a diverse cadre of young scientists to careers in immune disease-focused investigation and equip them for success. An increasing awareness of the role of the immune system in multiple diseases, coupled with technologic advances that allow analysis of microscopic quantities of human specimens have fueled exponential growth in the exploration and understanding of human immunopathologic conditions. Nevertheless, effective therapies for many immune disorders are still lacking. Highly motivated individuals completing training programs in immunology, particularly physician-scientists, are needed to enable rigorous and creative advances in biomedical research that will enhance our understanding of disease pathogenesis and suggest strategies to improve the outcome of patients with immune disorders. Our proposal engages 21 mentors at all career levels and is built around 4 areas of scientific excellence in immunology: 1) Autoimmunity; 2) Neuroimmune inflammation; 3) Tissue injury, inflammation and innate immunity and 4) Tumor immunology. In each area, our faculty investigate disease mechanisms using specimens from well-established clinical cohorts and biorepositories and perform human- relevant studies that range from focused studies in model organisms to clinical trials of novel therapies. Specific aims are: 1. To recruit trainees who are diverse with respect to demographics, experience and interests; 2. To provide a multi-disciplinary “toolbox” curriculum needed for a successful career in human and translational investigation; 3. To teach trainees how to conduct creative, rigorous and ethical independent research that is driven by observations in human disease and that uses state of the art technologies to generate and test new hypotheses related to immune mediated diseases; 4. To engage faculty, students and our advisory committee in an ongoing self-evaluation process that will foster the continued growth and improvement of our training program; 5. To mentor and create a new generation of translational immunologists who will collaboratively tackle research problems linked to improving clinical outcomes of patients with immune- mediated diseases. By combining existing courses that are part of the established infrastructure of the Elmezzi Graduate Program in Molecular Medicine and the Zucker School of Medicine at Hofstra University-Northwell Health with new curricular elements designed for this training program, including programs in leadership, conflict resolution, resilience and more, we can provide an enriched and motivating experience for our trainees. In this fashion we will develop physician- scientists and translational investigators who are focused on human disease and equipped with a broad understanding of immunology, modern technologies and the resilience to persevere.

这一新的T32计划旨在提供严格的翻译培训计划 免疫学博士后2名，博士后1名。它将招募一支多元化的干部队伍 年轻科学家投身以免疫疾病为重点的研究并为他们做好准备 成功。人们对免疫系统在多种疾病中的作用的认识日益增强， 再加上技术的进步，可以分析微量的人类 标本推动了人类探索和理解的指数性增长 免疫病理条件。然而，许多免疫疾病的有效治疗方法是 还是不够用。高积极性的人完成免疫学培训计划， 尤其是内科科学家，才能在以下方面取得严格和创造性的进展 生物医学研究将增强我们对疾病发病机制的理解，并建议 改善免疫紊乱患者预后的策略。我们的计划涉及21个 所有职业水平的导师，并围绕免疫学的4个卓越科学领域建立：1) 自身免疫；2)神经免疫性炎症；3)组织损伤、炎症和先天 免疫和肿瘤免疫学。在每个领域，我们的教员都在研究疾病的机制。 使用来自完善的临床队列和生物信息库的样本，并执行人类- 相关研究，从模型生物的重点研究到新药的临床试验 治疗。具体目标是： 1.招募不同人口、经验和兴趣的学员； 2.提供人类事业成功所需的多学科“工具箱”课程 和翻译调查； 3.教学员如何进行创造性、严谨和有道德的独立研究，即 由对人类疾病的观察驱动，并使用最先进的技术来产生 并测试与免疫介导性疾病相关的新假说； 4.让教职员工、学生和我们的顾问委员会参与持续的自我评估 这一过程将促进我们培训计划的持续增长和改进； 5.指导和培养新一代翻译免疫学家，他们将合作 解决与改善免疫缺陷患者临床结局相关的研究问题 媒介疾病。 通过合并作为Elmezzi既定基础设施一部分的现有课程 霍夫斯特拉大学分子医学研究生课程和扎克医学院 大学-诺斯韦尔健康学院为这一培训项目设计了新的课程内容， 包括领导力、冲突解决、恢复力等课程，我们可以提供 为我们的实习生提供丰富和鼓舞人心的体验。以这种方式，我们将发展医生- 专注于人类疾病并配备有 对免疫学、现代技术和坚持不懈的韧性有广泛的了解。

项目成果

kHz-frequency electrical stimulation selectively activates small, unmyelinated vagus afferents.

• DOI: 10.1016/j.brs.2022.09.015
• 发表时间: 2022-11
• 期刊: BRAIN STIMULATION
• 影响因子: 7.7
• 作者: Chang, Yao-Chuan;Ahmed, Umair;Jayaprakash, Naveen;Mughrabi, Ibrahim;Lin, Qihang;Wu, Yi-Chen;Gerber, Michael;Abbas, Adam;Daytz, Anna;Gabalski, Arielle H.;Ashville, Jason;Dokos, Socrates;Rieth, Loren;Datta-Chaudhuri, Timir;Tracey, Kevin J.;Guo, Tianruo;Al -Abed, Yousef;Zanos, Stavros
• 通讯作者: Zanos, Stavros

Maternal brain reactive antibodies profile in autism spectrum disorder: an update.

• DOI: 10.1038/s41398-023-02335-3
• 发表时间: 2023-02-03
• 期刊: TRANSLATIONAL PSYCHIATRY
• 影响因子: 6.8
• 作者: Bagnall-Moreau, Ciara;Spielman, Benjamin;Brimberg, Lior
• 通讯作者: Brimberg, Lior

Navigating the marrow sea towards erythromyeloblastic islands under normal and inflammatory conditions.

在正常和炎症条件下，在骨髓海中航行至红骨髓细胞岛。

• DOI: 10.1097/moh.0000000000000756
• 发表时间: 2023
• 期刊: Current opinion in hematology
• 影响因子: 3.2
• 作者: Josselsohn,Rachel;Barnes,BetsyJ;Kalfa,TheodosiaA;Blanc,Lionel
• 通讯作者: Blanc,Lionel