T32 Training Grant in Translational Immunology

T32 转化免疫学培训补助金

• 批准号: 10269999
• 负责人: Anne Davidson
• 金额: $ 16.73万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10269999
• 关键词: Grant; Immunology; Training

This new T32 program is designed to provide a rigorous training program in translational immunology for 2 pre-doctoral and one post-doctoral candidate. It will recruit a diverse cadre of young scientists to careers in immune disease-focused investigation and equip them for success. An increasing awareness of the role of the immune system in multiple diseases, coupled with technologic advances that allow analysis of microscopic quantities of human specimens have fueled exponential growth in the exploration and understanding of human immunopathologic conditions. Nevertheless, effective therapies for many immune disorders are still lacking. Highly motivated individuals completing training programs in immunology, particularly physician-scientists, are needed to enable rigorous and creative advances in biomedical research that will enhance our understanding of disease pathogenesis and suggest strategies to improve the outcome of patients with immune disorders. Our proposal engages 21 mentors at all career levels and is built around 4 areas of scientific excellence in immunology: 1) Autoimmunity; 2) Neuroimmune inflammation; 3) Tissue injury, inflammation and innate immunity and 4) Tumor immunology. In each area, our faculty investigate disease mechanisms using specimens from well-established clinical cohorts and biorepositories and perform human- relevant studies that range from focused studies in model organisms to clinical trials of novel therapies. Specific aims are: 1. To recruit trainees who are diverse with respect to demographics, experience and interests; 2. To provide a multi-disciplinary “toolbox” curriculum needed for a successful career in human and translational investigation; 3. To teach trainees how to conduct creative, rigorous and ethical independent research that is driven by observations in human disease and that uses state of the art technologies to generate and test new hypotheses related to immune mediated diseases; 4. To engage faculty, students and our advisory committee in an ongoing self-evaluation process that will foster the continued growth and improvement of our training program; 5. To mentor and create a new generation of translational immunologists who will collaboratively tackle research problems linked to improving clinical outcomes of patients with immune- mediated diseases. By combining existing courses that are part of the established infrastructure of the Elmezzi Graduate Program in Molecular Medicine and the Zucker School of Medicine at Hofstra University-Northwell Health with new curricular elements designed for this training program, including programs in leadership, conflict resolution, resilience and more, we can provide an enriched and motivating experience for our trainees. In this fashion we will develop physician- scientists and translational investigators who are focused on human disease and equipped with a broad understanding of immunology, modern technologies and the resilience to persevere.

这个新的T32计划旨在提供一个严格的翻译培训计划， 免疫学2名博士前和一名博士后候选人。它将招募一个多样化的干部， 年轻的科学家在免疫疾病为重点的调查和装备他们的职业生涯 成功越来越多的人认识到免疫系统在多种疾病中的作用， 再加上技术的进步，使分析微观数量的人类 标本已经推动了人类探索和理解的指数增长， 免疫病理条件。然而，许多免疫疾病的有效疗法是 仍然缺乏。积极主动完成免疫学培训项目的个人， 特别是物理学家，科学家，需要使严格和创造性的进展， 生物医学研究，将提高我们对疾病发病机制的理解，并建议 改善免疫系统疾病患者预后的策略。我们的建议涉及21个 在所有职业水平的导师，并围绕免疫学的4个卓越的科学领域建立：1） 自身免疫; 2）神经免疫炎症; 3）组织损伤、炎症和先天性 4）肿瘤免疫学。在每个领域，我们的教师研究疾病机制 使用来自完善的临床队列和生物储存库的标本，并进行人类- 相关研究范围从模式生物的重点研究到新药物的临床试验， 治疗具体目标是： 1.招聘在人口统计、经验和兴趣方面各不相同的受训人员; 2.提供一个多学科的“工具箱”课程需要一个成功的职业生涯在人类 翻译研究; 3.教导学员如何进行创造性的，严谨的和道德的独立研究， 由对人类疾病的观察驱动，并使用最先进的技术来产生 并测试与免疫介导疾病相关的新假设; 4.让教师，学生和我们的咨询委员会参与持续的自我评估 这将促进我们的培训计划的持续增长和改进的过程; 5.指导和创造新一代的翻译免疫学家，他们将与 解决与改善免疫缺陷患者临床结果相关的研究问题， 介导的疾病。 通过结合现有的课程，是Elmezzi既定基础设施的一部分， 分子医学研究生课程和霍夫斯特拉大学Zucker医学院 大学诺斯韦尔健康与新的课程元素设计的这个培训计划， 包括领导力，解决冲突，恢复力等项目，我们可以提供一个 丰富和激励我们的学员的经验。我们将以这种方式培养医生- 专注于人类疾病的科学家和翻译研究人员， 对免疫学、现代技术和坚持不懈的韧性有广泛的理解。