T32 Training Grant in Translational Immunology

这个新的 T32 计划旨在提供严格的翻译培训计划 免疫学博士生2名，博士后1名。它将招募多元化的骨干队伍 年轻科学家从事以免疫疾病为重点的研究，并为他们做好准备 成功。人们越来越认识到免疫系统在多种疾病中的作用， 再加上技术进步，可以分析人类的微观数量 标本推动了人类探索和理解的指数级增长 免疫病理状况。尽管如此，许多免疫疾病的有效疗法仍然存在 仍然缺乏。积极主动地完成免疫学培训课程的个人， 特别是医师科学家，需要在以下方面取得严格和创造性的进步 生物医学研究将增强我们对疾病发病机制的理解并提出建议 改善免疫疾病患者预后的策略。我们的提案涉及 21 各个职业级别的导师，围绕免疫学领域的 4 个卓越科学领域建立：1) 自身免疫； 2）神经免疫炎症； 3）组织损伤、炎症和先天性 免疫学和4）肿瘤免疫学。在每个领域，我们的教师都研究疾病机制 使用来自完善的临床队列和生物样本库的样本，并进行人类- 相关研究范围从模式生物的重点研究到新型药物的临床试验 疗法。具体目标是： 1. 招募在人口统计、经验和兴趣方面多样化的学员； 2. 提供人类成功职业生涯所需的多学科“工具箱”课程 和转化研究； 3. 教导学员如何进行创造性、严谨和符合道德的独立研究 由对人类疾病的观察驱动，并使用最先进的技术来产生 并测试与免疫介导疾病相关的新假设； 4. 让教师、学生和我们的咨询委员会参与持续的自我评估 将促进我们培训计划持续发展和改进的流程； 5. 指导和培养新一代转化免疫学家，他们将合作 解决与改善免疫缺陷患者临床结果相关的研究问题 介导的疾病。 通过结合属于 Elmezzi 现有基础设施一部分的现有课程 分子医学研究生项目和霍夫斯特拉扎克医学院 诺斯韦尔健康大学为此培训项目设计了新的课程内容， 包括领导力、冲突解决、复原力等方面的计划，我们可以提供 为我们的学员提供丰富且激励人心的经历。以这种方式，我们将培养医生- 专注于人类疾病并配备了 对免疫学、现代技术和坚持不懈的韧性有广泛的了解。

This new T32 program is designed to provide a rigorous training program in translational immunology for 2 pre-doctoral and one post-doctoral candidate. It will recruit a diverse cadre of young scientists to careers in immune disease-focused investigation and equip them for success. An increasing awareness of the role of the immune system in multiple diseases, coupled with technologic advances that allow analysis of microscopic quantities of human specimens have fueled exponential growth in the exploration and understanding of human immunopathologic conditions. Nevertheless, effective therapies for many immune disorders are still lacking. Highly motivated individuals completing training programs in immunology, particularly physician-scientists, are needed to enable rigorous and creative advances in biomedical research that will enhance our understanding of disease pathogenesis and suggest strategies to improve the outcome of patients with immune disorders. Our proposal engages 21 mentors at all career levels and is built around 4 areas of scientific excellence in immunology: 1) Autoimmunity; 2) Neuroimmune inflammation; 3) Tissue injury, inflammation and innate immunity and 4) Tumor immunology. In each area, our faculty investigate disease mechanisms using specimens from well-established clinical cohorts and biorepositories and perform human- relevant studies that range from focused studies in model organisms to clinical trials of novel therapies. Specific aims are: 1. To recruit trainees who are diverse with respect to demographics, experience and interests; 2. To provide a multi-disciplinary “toolbox” curriculum needed for a successful career in human and translational investigation; 3. To teach trainees how to conduct creative, rigorous and ethical independent research that is driven by observations in human disease and that uses state of the art technologies to generate and test new hypotheses related to immune mediated diseases; 4. To engage faculty, students and our advisory committee in an ongoing self-evaluation process that will foster the continued growth and improvement of our training program; 5. To mentor and create a new generation of translational immunologists who will collaboratively tackle research problems linked to improving clinical outcomes of patients with immune- mediated diseases. By combining existing courses that are part of the established infrastructure of the Elmezzi Graduate Program in Molecular Medicine and the Zucker School of Medicine at Hofstra University-Northwell Health with new curricular elements designed for this training program, including programs in leadership, conflict resolution, resilience and more, we can provide an enriched and motivating experience for our trainees. In this fashion we will develop physician- scientists and translational investigators who are focused on human disease and equipped with a broad understanding of immunology, modern technologies and the resilience to persevere.