UCLA Clinical Translational Science Institute

总体来说 项目摘要/摘要 加州大学洛杉矶分校临床和翻译科学研究所是加州大学洛杉矶分校-韦斯特伍德，锡达斯- 西奈医学中心，查尔斯·R·德鲁医科大学和洛杉矶生物医学 位于港湾-加州大学洛杉矶分校医学中心。它的使命是将生物医学创新应用于最伟大的 洛杉矶的医疗需求--洛杉矶规模最大、种族、社会和经济最多元化的城市之一 美国的几个县。通过这样做，我们的目标是成为CTSA联盟的主要贡献者 加快科学翻译，造福整个国家。CTSI有五个目标：(1)准备 从事高质量、多学科团队科学研究的翻译团队；(2)吸引利益相关者 社区参与临床和转化性研究，传播成功的合作模式； (3)将特殊人群，特别是那些存在健康差距的人群纳入研究；(4) 改进方法和流程以加快科学翻译，克服关键障碍和 支持多站点研究；(5)为业务和科学障碍提供信息学解决方案，以 在加州大学洛杉矶分校CTSI和CTSA网络内推进高影响力的翻译科学。我们的小说 基础设施包括：洛杉矶数据资源(LADR)，这是来自 六个洛杉矶机构；其治理协议是CTSA ACT倡议的典范； 洛杉矶县的创新和实施核心，这是一个测试改进方法的实验室 为县卫生系统每年接受治疗的近70万人提供护理；精准医疗计划 这构成了将基因组水平的诊断带入转译研究和临床护理的基础 在我们的加州大学洛杉矶分校中心，多个CTSA和合作机构；一个整合了 在职培训经验中的创业原则，指导调查人员利用他们的 当他们将他们的发现带到产品中时，他们拥有自己的发现。我们计划将我们的CTSI从一个高- 将运作良好的服务组织转变为一个集成良好的研究加速器，该加速器将开发、演示和 为洛杉矶社区的最终利益，为翻译障碍传播新的解决方案， 我们的地区和国家。

OVERALL PROJECT SUMMARY/ABSTRACT The UCLA Clinical and Translational Science Institute is a research partnership of UCLA-Westwood, Cedars- Sinai Medical Center, Charles R. Drew University of Medicine and Science and the Los Angeles Biomedical Institute at Harbor-UCLA Medical Center. Its mission is to bring biomedical innovations to bear on the greatest health needs of Los Angeles—the largest and one of the most ethnically, socially and economically diverse counties in the United States. In doing so, our goal is to become a leading contributor in the CTSA Consortium and speed scientific translation to benefit the nation as a whole. The CTSI has five aims: (1) Prepare the translational workforce to conduct high-quality, multidisciplinary team science; (2) Engage stakeholder communities in clinical and translational research and disseminate successful models of collaboration; (3) Integrate special populations, especially those experiencing health disparities, into research; (4) Improve methods and processes to accelerate scientific translation, overcome key roadblocks and support multisite research; (5) Provide informatics solutions to operational and scientific roadblocks to advance high-impact translational science within the UCLA CTSI and the CTSA network. Our novel infrastructure includes: The Los Angeles Data Resource (LADR), a federation of clinical data warehouses from six Los Angeles institutions; its governance agreement serves as the model for the CTSA ACT initiative; an Innovation and Implementation Core with Los Angeles County, a laboratory for testing approaches for improving care for the nearly 700,000 people annually treated in the county health system; a Precision Medicine program that forms the infrastructure to bring genomic-level diagnosis to translational investigation and clinical care across our UCLA Hub, multiple CTSAs and partner institutions; a training program that integrates entrepreneurship principles in on-the-job training experiences in which investigators are guided to utilize their own findings as they bring their discoveries to products. We propose to transform our CTSI from a high- functioning service organization into a well-integrated research accelerator that will develop, demonstrate and disseminate novel solutions to translational roadblocks, to the ultimate benefit of the Los Angeles community, our region and the nation.