UCLA Clinical Translational Science Institute

联系PD/PI：Dubinett，Steven M. 整体 项目总结/摘要 加州大学洛杉矶分校临床和转化科学研究所是加州大学洛杉矶分校韦斯特伍德，雪松， 西奈医疗中心，查尔斯河。德鲁医学与科学大学和洛杉矶生物医学 加州大学洛杉矶分校海港医学中心（Harbor UCLA Medical Center）它的使命是将生物医学创新应用于最大的 洛杉矶的健康需求-最大的和最种族，社会和经济多样性之一 在美国的县。我们的目标是成为CTSA联盟的主要贡献者 加快科技成果转化，造福全国。CTSI有五个目标：（1）编写 翻译团队进行高质量的，多学科的团队科学;（2）参与利益相关者 社区的临床和转化研究，并传播成功的模式， （3）将特殊人群，特别是那些经历健康差距的人， （4）改进方法和流程，加快科学翻译，克服关键问题， 障碍和支持多站点研究;（5）为运营和 在加州大学洛杉矶分校CTSI和CTSA内推进高影响力转化科学的科学障碍 网络我们的新型基础设施包括：洛杉矶数据资源（LADR），一个临床 来自六个洛杉矶机构的数据仓库;其治理协议作为 CTSA ACT计划;洛杉矶县的创新和实施核心，一个测试实验室 改善每年在县卫生系统接受治疗的近70万人的护理的方法; 精准医学计划，形成了将基因组水平诊断转化为 我们的UCLA中心，多个CTSA和合作机构的调查和临床护理;培训 一个程序，将创业原则纳入在职培训经验，其中调查人员 指导他们利用自己的发现，因为他们把他们的发现，以产品。我们建议将我们的 CTSI从一个高功能的服务组织转变为一个整合良好的研究加速器， 展示和传播新的解决方案，以翻译的路障，以洛杉矶的最终利益 洛杉矶社区，我们的地区和国家。 项目摘要/摘要第745页 联系PD/PI：Dubinett，Steven M. 整体

Contact PD/PI: Dubinett, Steven M. OVERALL PROJECT SUMMARY/ABSTRACT The UCLA Clinical and Translational Science Institute is a research partnership of UCLA-Westwood, Cedars- Sinai Medical Center, Charles R. Drew University of Medicine and Science and the Los Angeles Biomedical Institute at Harbor UCLA Medical Center. Its mission is to bring biomedical innovations to bear on the greatest health needs of Los Angeles—the largest and one of the most ethnically, socially and economically diverse counties in the United States. In doing so, our goal is to become a leading contributor in the CTSA Consortium and speed scientific translation to benefit the nation as a whole. The CTSI has five aims: (1) Prepare the translational workforce to conduct high-quality, multidisciplinary team science; (2) Engage stakeholder communities in clinical and translational research and disseminate successful models of collaboration; (3) Integrate special populations, especially those experiencing health disparities, into research; (4) Improve methods and processes to accelerate scientific translation, overcome key roadblocks and support multisite research; (5) Provide informatics solutions to operational and scientific roadblocks to advance high-impact translational science within the UCLA CTSI and the CTSA network. Our novel infrastructure includes: The Los Angeles Data Resource (LADR), a federation of clinical data warehouses from six Los Angeles institutions; its governance agreement serves as the model for the CTSA ACT initiative; an Innovation and Implementation Core with Los Angeles County, a laboratory for testing approaches for improving care for the nearly 700,000 people annually treated in the county health system; a Precision Medicine program that forms the infrastructure to bring genomic-level diagnosis to translational investigation and clinical care across our UCLA Hub, multiple CTSAs and partner institutions; a training program that integrates entrepreneurship principles in on-the-job training experiences in which investigators are guided to utilize their own findings as they bring their discoveries to products. We propose to transform our CTSI from a high-functioning service organization into a well-integrated research accelerator that will develop, demonstrate and disseminate novel solutions to translational roadblocks, to the ultimate benefit of the Los Angeles community, our region and the nation. Project Summary/Abstract Page 745 Contact PD/PI: Dubinett, Steven M. OVERALL