The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy

在这项旨在加强正在进行的肺PCA研究的提案中，我们提出的目的是检查在肺癌发展的不同阶段，关键的SARS-CoV-2病毒进入基因上调的蛋白质定位、细胞类型特异性表达和生物途径。我们将把这些结果与关键的SARS-CoV-2病毒进入基因的蛋白表达以及免疫、上皮和内皮细胞蛋白在新冠肺炎死亡患者的肺组织中以及从新冠肺炎疾病前后采集的肺组织中进行比较。对肺癌发生过程中的上皮和间质微环境以及SARS-CoV-2关键进入基因的表达进行空间表征，可能会确定改善这一高危患者群体的临床管理和改善新冠肺炎预后的潜在途径

In this proposal, that enhances ongoing Lung PCA studies, we propose aims to examine the protein localization, cell type specific expression, and biological pathways up-regulated with key SARS-CoV-2 viral entry genes across the various stages of lung cancer development. We will compare these results with protein expression of key SARS-CoV-2 viral entry genes as well as immune, epithelial, and endothelial cell proteins in lung tissue from patients that died from COVID-19, and from lung tissue sampled pre- and post-COVID-19 disease. Spatially characterizing the epithelium and stromal microenvironment and expression of key SARS-CoV-2 entry genes during the development of lung cancer in the central airway and the alveoli may identify potential ways to improve clinical management of this high-risk patient population and improve COVID-19 outcomes