Improved biosecurity for the SPF M. nemestrina breeding colony

项目总结/摘要 华盛顿国家灵长类动物研究中心（WaNPRC）是最大的国内繁殖基地， 长尾猕猴。我们正在为U42 OD 011123申请补充资金， 无特定病原体（SPF）的Macaca nemestrina（小尾猕猴）繁殖群，以安装 自动笼/架洗衣机在我们的亚利桑那州繁殖殖民地（ABC）。家长奖的目的是 提供健康的SPF M。用于艾滋病毒/艾滋病相关研究和其他生物医学研究的nemestrina 空房的该育种在卫星ABC设施中在固定群围栏中进行。但据 需要维持一些个人便携式笼舍，以容纳生病或受伤的动物进行临床治疗。 目前，这种笼子是用手清洗和化学消毒的，这并不理想。 在ABC而不是在西雅图繁殖有几个优势，但是在亚利桑那州有山谷的风险。 由球孢子菌孢子引起的发烧，这是该地区的地方病。我们目前正在 在ABC的一栋住宅楼上扩建，以允许清洁的笼子储存， 暴露在孢子中我们正在申请资金在这座大楼里安装一个自动笼/架清洗机， 清洁和消毒便携式笼和浓缩物品。我们还需要安装运行所需的实用程序 笼式洗衣机，包括190ºF热水器，电气服务和HEPA过滤HVAC。我们将安装 太阳能电池板，以支持笼式/机架式洗衣机的运营成本，这将持续支持这一点 未来几年的装备。 通过防止动物暴露于潜在病原体，自动笼/架清洗机将支持 繁殖群体中动物的身体健康。在安装太阳能电池板的同时， 将利用这个机会在建筑物的动物房部分插入天窗。自然光将 促进繁殖群体中动物的心理健康。这些修改虽然不是一部分， 家长奖，将促进动物的健康和福祉，有助于整体成功的 为未来的研究提供支持

PROJECT SUMMARY/ABSTRACT The Washington National Primate Research Center (WaNPRC) is the largest domestic breeding colony for Macaca nemestrina, the pigtailed macaque. We are requesting supplementary funding for U42 OD011123, Specific Pathogen Free (SPF) Macaca nemestrina (pigtailed macaque) Breeding Colony, to install an automatic cage/rack washer at our Arizona Breeding Colony (ABC). The purpose of the parent award is to provide healthy, SPF M. nemestrina for HIV/AIDS-related research, and other biomedical research pending availability. This breeding is performed at the satellite ABC facility in fixed group enclosures. However, it is necessary to maintain some individual portable caging to house ill or injured animals for clinical treatment. This caging is currently washed by hand and disinfected chemically, which is not ideal. Breeding at ABC rather than in Seattle has several advantages; however in Arizona there is a risk of Valley Fever caused by Coccidioides fungal spores which are endemic in that area. We are currently in the process of building an extension on one of the housing buildings at ABC to allow for clean cage storage and prevent exposure to the spores. We are requesting funds to install an automatic cage/rack washer in this building to clean and sanitize portable caging and enrichment items. We will also need to install the utilities needed to run the cage washer, including a 190ºF water heater, electrical service, and HEPA-filtered HVAC. We will install solar panels to support the operational costs of the cage/rack washer, which will sustain support for this equipment in future years. By preventing exposure of animals to potential pathogens, the automatic cage/rack washer will support the physical well-being of animals in the breeding colony. In conjunction with the installation of the solar panels we will take the opportunity to insert skylights in the animal housing section of the building. This natural light will promote the psychological well-being of the animals in the breeding colony. These modifications, while not part of the parent award, will promote the health and well-being of the animals contributing to the overall success of the breeding colony in support of future research.