Improved biosecurity for the SPF M. nemestrina breeding colony

改善 SPF M. nemestrina 繁殖群的生物安全性

• 批准号: 10404863
• 负责人: CHARLOTTE HOTCHKISS
• 金额: $ 49.19万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10404863
• 关键词: AIDS/HIV problem; Animal Genetics; Animal Housing; Animal Welfare; Animals; Area; Arizona; Award; Biomedical Research; Breeding; Cercopithecine Herpesvirus 1; Chemicals; Clinical Treatment; Coccidioides; Ensure; Environment; Equipment; Exanthema; Excision; Exposure to; Funding; Fungal Spores; Future; Hand; Handwashing; Health; Health Promotion; Hospitals; Housing; Incidence; Individual; Light; Macaca nemestrina; Modification; Parents; Personal Satisfaction; Primates; Process; Reproduction spores; Research; Risk; Running; SIV; Services; Shelter facility; Simian Retroviruses; Virus; Washington; Water; Well in self; animal care; biosecurity; cost; desert fever; germ free condition; high efficiency particulate air filter; improved; injured; pathogen; pathogen exposure; physical conditioning; portability; prevent; success; transmission process; ventilation

PROJECT SUMMARY/ABSTRACT The Washington National Primate Research Center (WaNPRC) is the largest domestic breeding colony for Macaca nemestrina, the pigtailed macaque. We are requesting supplementary funding for U42 OD011123, Specific Pathogen Free (SPF) Macaca nemestrina (pigtailed macaque) Breeding Colony, to install an automatic cage/rack washer at our Arizona Breeding Colony (ABC). The purpose of the parent award is to provide healthy, SPF M. nemestrina for HIV/AIDS-related research, and other biomedical research pending availability. This breeding is performed at the satellite ABC facility in fixed group enclosures. However, it is necessary to maintain some individual portable caging to house ill or injured animals for clinical treatment. This caging is currently washed by hand and disinfected chemically, which is not ideal. Breeding at ABC rather than in Seattle has several advantages; however in Arizona there is a risk of Valley Fever caused by Coccidioides fungal spores which are endemic in that area. We are currently in the process of building an extension on one of the housing buildings at ABC to allow for clean cage storage and prevent exposure to the spores. We are requesting funds to install an automatic cage/rack washer in this building to clean and sanitize portable caging and enrichment items. We will also need to install the utilities needed to run the cage washer, including a 190ºF water heater, electrical service, and HEPA-filtered HVAC. We will install solar panels to support the operational costs of the cage/rack washer, which will sustain support for this equipment in future years. By preventing exposure of animals to potential pathogens, the automatic cage/rack washer will support the physical well-being of animals in the breeding colony. In conjunction with the installation of the solar panels we will take the opportunity to insert skylights in the animal housing section of the building. This natural light will promote the psychological well-being of the animals in the breeding colony. These modifications, while not part of the parent award, will promote the health and well-being of the animals contributing to the overall success of the breeding colony in support of future research.

项目概要/摘要 华盛顿国家灵长类动物研究中心 (WaNPRC) 是国内最大的灵长类动物繁殖地 Macaca nemestrina，辫子猕猴。我们正在为 U42 OD011123 请求补充资金， 特定无病原体 (SPF) 猕猴（辫尾猕猴）繁殖群，安装 我们亚利桑那州育种场 (ABC) 的自动笼/架清洗机。家长奖的目的是 为 HIV/AIDS 相关研究和其他待定的生物医学研究提供健康的 SPF M. nemestrina 可用性。这种繁殖是在 ABC 卫星设施的固定群体围栏内进行的。然而，它是 有必要维持一些单独的便携式笼子来容纳患病或受伤的动物进行临床治疗。 这种笼子目前是用手清洗并进行化学消毒，效果并不理想。 与西雅图相比，在 ABC 进行育种有几个优势：然而在亚利桑那州存在山谷的风险 由该地区流行的球孢子菌孢子引起的发烧。我们目前正在处理中 在 ABC 的一栋住宅楼上扩建，以允许干净的笼子存储并防止 暴露于孢子。我们正在申请资金在这座大楼内安装自动笼式/架式清洗机，以 清洁和消毒便携式笼子和浓缩物品。我们还需要安装运行所需的实用程序 笼式洗衣机，包括 190°F 热水器、电力服务和 HEPA 过滤的 HVAC。我们将安装 太阳能电池板用于支持笼式/架式清洗机的运营成本，这将维持对此的支持 未来几年的设备。 通过防止动物接触潜在的病原体，自动笼/架清洗机将支持 繁殖群中动物的身体健康。结合太阳能电池板的安装，我们 将借此机会在建筑物的动物住房部分插入天窗。这种自然光将 促进繁殖群体中动物的心理健康。这些修改虽然不属于 家长奖将促进动物的健康和福祉，为整体成功做出贡献 支持未来研究的繁殖群体。