Training in Intellectual and Developmental Disabilities (IDD) Research

这是一个新的T32机构培训计划的申请，以支持博士后在智力和 发展性残疾(IDDS)。罗斯·肯尼迪中心及其IDD研究项目已有50年的历史 在大脑发育、功能和疾病方面的最新发现。今天，我们正处于一个前所未有的时代 发现与缺碘相关的新基因和基因变异，以及环境和相关条件。同时 随着时间的推移，我们在神经科学、遗传学和细胞学的现代研究工具方面取得了显著的进步 分子生物学。我们的目标是创建一个充满活力的新培训计划，成功地将有才华的人聚集在一起 博士后研究员与世界级研究人员及其实验室合作开发下一代 事业心强、事业有成的IDD研究科学家。这项计划的四个主要目标是(1) 为高水平博士后提供生物医学科学方面的深入研究经验和教学培训 以一种方式塑造他们的终身职业目标，同时促进发现和进步 (2)建立有效的跨学科沟通； 基础研究实验室和专注于IDD的诊所之间的合作，使我们的博士后实习生对 (3)扩大受训者及其实验室之间的合作网络， 和临床医生及其诊所，尽可能包括父母/护理提供者和受缺碘影响的患者； 以及(4)为我们的学员提供职业指导和职业发展，这与我们的目标相结合 招募和培训代表性不足的少数群体成员。为了实现这些重要目标，我们有Assem- 汇聚了一支由36名才华横溢的初级培训师组成的团队，他们是从我们的100名成员Rose F.Kennedy IDDRC成员中挑选出来的。 这些人来自15个基础科学和临床部门，他们跨越了许多研究IDD的方法- 从包括IPSC研究在内的人类调查，到IDDS的老鼠、鱼、苍蝇和蠕虫模型。此外，我们还有 制定了一项有组织的培训计划，旨在扩大学员对IDD的关注，远远超出直接实验室的范围 经验。我们还建立了指导委员会的计划，以指导我们的学员并进行评估 这些流程使我们能够持续监控和修改我们的计划，以确保我们走上了实现既定目标的轨道。 最后，我们让我们的临床合作伙伴参与IDDS患者的工作，并为他们在 培训计划。这个项目带来了我们机构相当深入、严谨的科学方法，以及 传统的创新担负着对智力残疾的成因、治疗和预防的重要研究。

This application is for a new T32 institutional training program to support postdoctoral research in intellectual and developmental disabilities (IDDs). The Rose F. Kennedy Center and its program of IDD research has for 50 years been in the forefront of discoveries in brain development, function and disease. Today, we are in an era of unprecedented discovery of new genes and gene variants, as well as environmental and related conditions, linked to IDD. At the same time, we are armed with remarkable advances in modern research tools in neuroscience, genetics and in cell and molecular biology. Our goal here is to create a vibrant new training program that successfully brings together talented postdoctoral fellows working with world-class investigators and their laboratories to develop the next generation of highly motivated and successful IDD-focused research scientists. The four broad objectives of this program are (1) to provide in-depth research experiences and didactic training in biomedical science for highly talented postdoctoral fellows in a manner that shapes their lifetime career objectives and at the same time fosters discovery and advancement of our understanding of, and ability to treat, specific types of IDDs; (2) to build effective cross-discipline communication between basic research laboratories and IDD-focused clinics, sensitizing our postdoctoral trainees to the perspective of IDD-focused clinicians and vice versa; (3) to extend this network of cooperation between trainees and their laboratories, and clinicians and their clinics, to encompass whenever possible the parents/care providers and IDD-affected patients; and (4) to provide career guidance and professional development to our trainees, with this effort coupled to our goal to recruit and train members of underrepresented minority groups. To accomplish these important goals, we have assem- bled a team of 36 highly talented primary trainers selected from our 100-member Rose F. Kennedy IDDRC membership. These individuals come from 15 basic science and clinical departments and span a host of research approaches to IDD – from human investigations including iPSC studies, to mouse, fish, fly and worm models of IDDs. In addition, we have developed a structured training program designed to broaden the trainees IDD-focus well beyond the immediate lab experience. We have also established a plan of mentoring committees to guide our trainees along with evaluation processes allowing us to continually monitor and modify our program to ensure we are on track to our stated goals. Finally, we have engaged our clinical partners working with patients with IDDs and established a strong role for them in the training program. This program brings our institution’s considerable depth, rigorous scientific approach, and tradition of innovation to bear on the important study of the cause, treatment and prevention of intellectual disability.