Training in Intellectual and Developmental Disabilities (IDD) Research

此应用程序是一个新的T32机构培训计划，以支持博士后研究的智力和 发展性残疾（IDDs）。玫瑰F。肯尼迪中心及其碘缺乏病研究计划已经有50年的历史， 大脑发育、功能和疾病的最前沿发现。今天，我们正处于一个前所未有的时代， 发现与缺碘症有关的新基因和基因变异以及环境和有关条件。在同一 与此同时，我们在神经科学、遗传学和细胞学的现代研究工具方面取得了显着进展， 分子生物学我们的目标是创建一个充满活力的新的培训计划，成功地汇集人才 博士后研究员与世界一流的研究人员及其实验室合作，开发下一代 高度积极和成功的以缺碘症为重点的研究科学家。该方案的四大目标是：（1） 为优秀的博士后提供深入的研究经验和生物医学科学的教学培训 研究员的方式，塑造他们的终身职业目标，同时促进发现和进步 我们对特定类型的IDDs的理解和治疗能力;（2）建立有效的跨学科沟通 基础研究实验室和以缺碘症为重点的诊所之间的联系，使我们的博士后学员对 （3）扩大受训人员与其实验室之间的合作网络， 以及临床医生及其诊所，尽可能包括父母/护理提供者和受缺碘症影响的病人; 及（4）为学员提供就业辅导及专业发展，并配合我们的目标， 招募和培训代表性不足的少数群体成员。为了实现这些重要目标，我们已完成- 从我们的100名成员中选出了36名才华横溢的初级培训师。肯尼迪IDDRC成员。 这些人来自15个基础科学和临床部门，跨越了一系列的研究方法，以碘缺乏病- 从包括iPSC研究在内的人类研究，到IDDs的小鼠、鱼类、苍蝇和蠕虫模型。另外我们有 制定了一个结构化的培训计划，旨在扩大学员的IDD重点远远超出了直接的实验室 体验.我们还建立了一个指导委员会的计划，以指导我们的学员沿着评估 流程，使我们能够持续监控和修改我们的计划，以确保我们在既定目标的轨道上。 最后，我们已经与我们的临床合作伙伴一起为IDD患者工作，并为他们在以下方面发挥了重要作用： 培训计划。该计划带来了我们机构的相当大的深度，严谨的科学方法， 创新传统，对智力残疾的病因、治疗和预防等方面的研究具有重要意义。

This application is for a new T32 institutional training program to support postdoctoral research in intellectual and developmental disabilities (IDDs). The Rose F. Kennedy Center and its program of IDD research has for 50 years been in the forefront of discoveries in brain development, function and disease. Today, we are in an era of unprecedented discovery of new genes and gene variants, as well as environmental and related conditions, linked to IDD. At the same time, we are armed with remarkable advances in modern research tools in neuroscience, genetics and in cell and molecular biology. Our goal here is to create a vibrant new training program that successfully brings together talented postdoctoral fellows working with world-class investigators and their laboratories to develop the next generation of highly motivated and successful IDD-focused research scientists. The four broad objectives of this program are (1) to provide in-depth research experiences and didactic training in biomedical science for highly talented postdoctoral fellows in a manner that shapes their lifetime career objectives and at the same time fosters discovery and advancement of our understanding of, and ability to treat, specific types of IDDs; (2) to build effective cross-discipline communication between basic research laboratories and IDD-focused clinics, sensitizing our postdoctoral trainees to the perspective of IDD-focused clinicians and vice versa; (3) to extend this network of cooperation between trainees and their laboratories, and clinicians and their clinics, to encompass whenever possible the parents/care providers and IDD-affected patients; and (4) to provide career guidance and professional development to our trainees, with this effort coupled to our goal to recruit and train members of underrepresented minority groups. To accomplish these important goals, we have assem- bled a team of 36 highly talented primary trainers selected from our 100-member Rose F. Kennedy IDDRC membership. These individuals come from 15 basic science and clinical departments and span a host of research approaches to IDD – from human investigations including iPSC studies, to mouse, fish, fly and worm models of IDDs. In addition, we have developed a structured training program designed to broaden the trainees IDD-focus well beyond the immediate lab experience. We have also established a plan of mentoring committees to guide our trainees along with evaluation processes allowing us to continually monitor and modify our program to ensure we are on track to our stated goals. Finally, we have engaged our clinical partners working with patients with IDDs and established a strong role for them in the training program. This program brings our institution’s considerable depth, rigorous scientific approach, and tradition of innovation to bear on the important study of the cause, treatment and prevention of intellectual disability.