Training in Intellectual and Developmental Disabilities (IDD) Research

智力和发育障碍 (IDD) 研究培训

• 批准号: 10636634
• 负责人: SOPHIE MOLHOLM
• 金额: $ 40.29万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10636634
• 关键词: Intellectual functioning disability; Research; Training

This application is for a new T32 institutional training program to support postdoctoral research in intellectual and developmental disabilities (IDDs). The Rose F. Kennedy Center and its program of IDD research has for 50 years been in the forefront of discoveries in brain development, function and disease. Today, we are in an era of unprecedented discovery of new genes and gene variants, as well as environmental and related conditions, linked to IDD. At the same time, we are armed with remarkable advances in modern research tools in neuroscience, genetics and in cell and molecular biology. Our goal here is to create a vibrant new training program that successfully brings together talented postdoctoral fellows working with world-class investigators and their laboratories to develop the next generation of highly motivated and successful IDD-focused research scientists. The four broad objectives of this program are (1) to provide in-depth research experiences and didactic training in biomedical science for highly talented postdoctoral fellows in a manner that shapes their lifetime career objectives and at the same time fosters discovery and advancement of our understanding of, and ability to treat, specific types of IDDs; (2) to build effective cross-discipline communication between basic research laboratories and IDD-focused clinics, sensitizing our postdoctoral trainees to the perspective of IDD-focused clinicians and vice versa; (3) to extend this network of cooperation between trainees and their laboratories, and clinicians and their clinics, to encompass whenever possible the parents/care providers and IDD-affected patients; and (4) to provide career guidance and professional development to our trainees, with this effort coupled to our goal to recruit and train members of underrepresented minority groups. To accomplish these important goals, we have assem- bled a team of 36 highly talented primary trainers selected from our 100-member Rose F. Kennedy IDDRC membership. These individuals come from 15 basic science and clinical departments and span a host of research approaches to IDD – from human investigations including iPSC studies, to mouse, fish, fly and worm models of IDDs. In addition, we have developed a structured training program designed to broaden the trainees IDD-focus well beyond the immediate lab experience. We have also established a plan of mentoring committees to guide our trainees along with evaluation processes allowing us to continually monitor and modify our program to ensure we are on track to our stated goals. Finally, we have engaged our clinical partners working with patients with IDDs and established a strong role for them in the training program. This program brings our institution’s considerable depth, rigorous scientific approach, and tradition of innovation to bear on the important study of the cause, treatment and prevention of intellectual disability.

该应用程序是针对新的T32机构培训计划，以支持知识分子的博士后研究 发展障碍（IDD）。罗斯·肯尼迪中心及其IDD研究计划已有50年了 大脑发育，功能和疾病中发现的最前沿。今天，我们正处于前所未有的时代 与IDD相关的新基因和基因变体以及环境和相关条件的发现。同样 时间，我们在神经科学，遗传学和细胞中的现代研究工具方面都有显着的进步 分子生物学。我们的目标是创建一个充满活力的新培训计划，成功地融合了才华横溢 博士后研究员与世界一流的调查员及其实验室一起发展下一代 高度积极进取，以IDD为重点的研究科学家。该程序的四个广泛对象是（1） 提供深入的研究经验和生物医学科学的教学培训，为才华横溢的博士后 研究员以塑造他们一生的职业目标的方式，同时促进了发现和进步 我们对特定类型的IDD的理解和能力； （2）建立有效的跨学科沟通 在基础研究实验室和以IDD为中心的诊所之间，使我们的博士后学员敏感 以IDD为中心的临床医生，反之亦然； （3）扩展学员与实验室之间的合作网络， 以及临床医生及其诊所，尽可能涵盖父母/护理提供者和受IDD影响的患者； （4）为我们的受训者提供职业指导和专业发展，并以这项努力与我们的目标相结合 招募人数不足的少数群体的招募和培训。为了实现这些重要目标，我们有了大会 - 流浪一支由36个才华横溢的小学培训师组成的团队，从我们的100名成员Rose F. Kennedy IDDRC成员中选出。 这些人来自15个基础科学和临床部门，涵盖了IDD的许多研究方法 - 从包括IPSC研究在内的人类投资到IDD的鼠标，鱼类，苍蝇和蠕虫模型。此外，我们还有 制定了一个结构化的培训计划 经验。我们还制定了指导承诺的计划，以指导我们的学员以及评估 流程使我们能够不断监视和修改程序，以确保我们步入既定目标。 最后，我们与患有IDD的患者合作的临床合作伙伴与他们的临床合作伙伴合作，并在他们中确立了强大的作用 培训计划。该计划带来了我们机构的考虑深度，严格的科学方法以及 创新的传统是对智力残疾的原因，治疗和预防的重要研究。