SUPPORT FOR THE ROSE F KENNEDY IDDRC P50

支持 ROSE F KENNEDY IDDRC P50

基本信息

  • 批准号:
    10669059
  • 负责人:
  • 金额:
    $ 100万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-23 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT (OVERALL) The overarching purpose of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK IDDRC) is to improve the lives of children with intellectual and developmental disabilities (IDDs). Fifty- plus years of distinguished progress in basic, translational and clinical research as one of NICHD’s flagship IDDRCs, coupled with important recent faculty recruitments and an historic merger between the Albert Einstein College of Medicine and its University-Affiliated Hospital, Montefiore Medical Center, offer a solid platform for continuing excellence in our commitment to IDD research. The Center’s 4 highly integrated scientific Cores consist of: 1) our clinical translational core known as the Human Clinical Phenotyping (Core B, HCP), which serves to facilitate both access to and characterization of participants for IDD relevant research; 2) a Neurogenomics facility (Core C, NGEN) that provides cutting edge epigenetic and genomic processing and analyses on both human and animal tissues; 3) a Neural Cell Engineering and Imaging facility (Core D, NCEI) that provides state-of-the-art approaches to brain cell manipulation and visualization; and 4) an Animal Phenotyping facility (Core E, AP) for evaluation of animal behavior, metabolism and imaging in a manner with strong parallels to approaches taken in patients accessed through HCP. Each of our scientific Cores is carefully overseen and monitored by the Administrative Core (Core A, ADM), which also serves as the head ganglion of the entire IDDRC in its substantial outreach programs to Einstein/Montefiore, the Bronx community as well as nationally. Each scientific Core has an essential connection to our signature Research Project which brings together a multidisciplinary team of investigators focused on mechanisms of IDD in children with mutations in the transcriptional regulator lysine demethylase 5c gene, KDM5C. A central function of the RFK IDDRC is to promote the substantive links between Einstein research laboratories and clinics at the Children's Evaluation and Rehabilitation Center (CERC) and the Children’s Hospital At Montefiore (CHAM). Together, our Cores and research project form a dynamic network – a community – of IDD-focused programs and practices that interlink 18 different academic departments, >100 IDDRC members and 20-plus IDD-relevant clinics at Einstein and Montefiore. The latter include 22q11.2DS, Rett and Williams syndromes, tuberous sclerosis, neurofibromatosis, West syndrome and infantile spasms, autism spectrum disorders, and a wide range of neurometabolic disorders. New initiatives moving forward at this time include our unique precision medicine/community outreach program we call Operation IDD Gene Team, our goal to fortify ties with our Einstein clinical partner (CERC and its affiliated UCEDD and LEND programs) under the umbrella of the Rose F. Kennedy Center and a heightened focus on training through our newly established T32 for IDD postdoctoral fellows.
项目摘要/摘要(总体)

项目成果

期刊论文数量(97)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies.
  • DOI:
    10.1038/s41582-020-00447-8
  • 发表时间:
    2021-04
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ballabh P;de Vries LS
  • 通讯作者:
    de Vries LS
A case of sporadic Peutz-Jeghers syndrome presenting as multiple intussusceptions.
  • DOI:
    10.1093/jscr/rjac070
  • 发表时间:
    2022-03
  • 期刊:
  • 影响因子:
    0.5
  • 作者:
    Gorji L;Huish G;Morgan J;Levy P
  • 通讯作者:
    Levy P
Is Pre-Symptomatic Immunosuppression Protective in CSF1R-Related Leukoencephalopathy?
在CSF1R相关的白细胞病变中,症状前免疫抑制是否存在?
Serotonin and Dopamine Mimic Glucose-Induced Reinforcement in C. elegans: Potential Role of NSM Neurons and the Serotonin Subtype 4 Receptor.
  • DOI:
    10.3389/fphys.2021.783359
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    4
  • 作者:
    Schwartz EKC;Sosner EN;Desmond HE;Lum SJ;Sze JY;Mobbs CV
  • 通讯作者:
    Mobbs CV
GUÍA: a digital platform to facilitate result disclosure in genetic counseling.
  • DOI:
    10.1038/s41436-020-01063-z
  • 发表时间:
    2021-05
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Suckiel SA;Odgis JA;Gallagher KM;Rodriguez JE;Watnick D;Bertier G;Sebastin M;Yelton N;Maria E;Lopez J;Ramos M;Kelly N;Teitelman N;Beren F;Kaszemacher T;Davis K;Laguerre I;Richardson LD;Diaz GA;Pearson NM;Ellis SB;Stolte C;Robinson M;Kovatch P;Horowitz CR;Gelb BD;Greally JM;Bauman LJ;Zinberg RE;Abul-Husn NS;Wasserstein MP;Kenny EE
  • 通讯作者:
    Kenny EE
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SOPHIE MOLHOLM其他文献

SOPHIE MOLHOLM的其他文献

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{{ truncateString('SOPHIE MOLHOLM', 18)}}的其他基金

HUMAN CLINICAL PHENOTYPING CORE
人类临床表型分析核心
  • 批准号:
    10455676
  • 财政年份:
    2021
  • 资助金额:
    $ 100万
  • 项目类别:
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50
支持 ROSE F KENNEDY IDDRC P50
  • 批准号:
    10239747
  • 财政年份:
    2021
  • 资助金额:
    $ 100万
  • 项目类别:
HUMAN CLINICAL PHENOTYPING CORE
人类临床表型分析核心
  • 批准号:
    10669062
  • 财政年份:
    2021
  • 资助金额:
    $ 100万
  • 项目类别:
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50
支持 ROSE F KENNEDY IDDRC P50
  • 批准号:
    10455674
  • 财政年份:
    2021
  • 资助金额:
    $ 100万
  • 项目类别:
HUMAN CLINICAL PHENOTYPING CORE
人类临床表型分析核心
  • 批准号:
    10239749
  • 财政年份:
    2021
  • 资助金额:
    $ 100万
  • 项目类别:
Training in Intellectual and Developmental Disabilities (IDD) Research
智力和发育障碍 (IDD) 研究培训
  • 批准号:
    10636634
  • 财政年份:
    2020
  • 资助金额:
    $ 100万
  • 项目类别:
Training in Intellectual and Developmental Disabilities (IDD) Research
智力和发育障碍 (IDD) 研究培训
  • 批准号:
    10404641
  • 财政年份:
    2020
  • 资助金额:
    $ 100万
  • 项目类别:
Training in Intellectual and Developmental Disabilities (IDD) Research
智力和发育障碍 (IDD) 研究培训
  • 批准号:
    10206216
  • 财政年份:
    2020
  • 资助金额:
    $ 100万
  • 项目类别:
Support for the Rose F. Kennedy IDDRC
对罗斯·F·肯尼迪 IDDRC 的支持
  • 批准号:
    9750051
  • 财政年份:
    2016
  • 资助金额:
    $ 100万
  • 项目类别:
Support for the Rose F. Kennedy IDDRC
对罗斯·F·肯尼迪 IDDRC 的支持
  • 批准号:
    9229419
  • 财政年份:
    2016
  • 资助金额:
    $ 100万
  • 项目类别:

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