权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

SUPPORT FOR THE ROSE F KENNEDY IDDRC P50

支持 ROSE F KENNEDY IDDRC P50

基本信息

批准号：
10669059
负责人：
SOPHIE MOLHOLM
金额：
$ 100万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-23 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10669059
关键词：
Advocate Affect Animal Behavior Animals Basic Science Biological Biology Charge Child Clinic Clinical Clinical Research Collaborations Communities Community Outreach Coupled Dedications DiGeorge Syndrome Diagnosis Disease Disorder of neurometabolic regulation Early Diagnosis Educational workshop Epigenetic Process Evaluation Faculty Faculty Recruitment Family Fostering Funding Ganglia Genes Genetic Transcription Genomics Goals Grant Head Hospitals Human Human Resources Image Infant Infantile spasms Institution Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Laboratory Research Leadership Link Lysine Medical Medical center Medicine Metabolism Mission Monitor Mutation National Institute of Child Health and Human Development Neonatal Screening Neurodevelopmental Disorder Neurofibromatoses Neurons Newsletter Online Systems Outcome Participant Pathogenesis Pathway interactions Patient Care Patients Pediatric Hospitals Phenotype Postdoctoral Fellow Quality Control Recruitment Activity Rehabilitation Centers Research Research Personnel Research Project Grants Rett Syndrome Role Science Scientist Services Solid Structure Students Talents Technology Time Training Training Programs Translating Translational Research Tuberous Sclerosis Universities Visualization Williams Syndrome animal tissue arm autism spectrum disorder brain cell cellular engineering cellular imaging clinical care clinical phenotype clinical training clinical translation college cost effectiveness design developmental disease forging fortification human tissue imaging facilities improved innovation insight member multidisciplinary multimodality neurogenomics next generation novel operation outreach outreach program precision medicine prevent programs research study screening program symposium tool

项目摘要

PROJECT SUMMARY/ABSTRACT (OVERALL) The overarching purpose of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK IDDRC) is to improve the lives of children with intellectual and developmental disabilities (IDDs). Fifty- plus years of distinguished progress in basic, translational and clinical research as one of NICHD’s flagship IDDRCs, coupled with important recent faculty recruitments and an historic merger between the Albert Einstein College of Medicine and its University-Affiliated Hospital, Montefiore Medical Center, offer a solid platform for continuing excellence in our commitment to IDD research. The Center’s 4 highly integrated scientific Cores consist of: 1) our clinical translational core known as the Human Clinical Phenotyping (Core B, HCP), which serves to facilitate both access to and characterization of participants for IDD relevant research; 2) a Neurogenomics facility (Core C, NGEN) that provides cutting edge epigenetic and genomic processing and analyses on both human and animal tissues; 3) a Neural Cell Engineering and Imaging facility (Core D, NCEI) that provides state-of-the-art approaches to brain cell manipulation and visualization; and 4) an Animal Phenotyping facility (Core E, AP) for evaluation of animal behavior, metabolism and imaging in a manner with strong parallels to approaches taken in patients accessed through HCP. Each of our scientific Cores is carefully overseen and monitored by the Administrative Core (Core A, ADM), which also serves as the head ganglion of the entire IDDRC in its substantial outreach programs to Einstein/Montefiore, the Bronx community as well as nationally. Each scientific Core has an essential connection to our signature Research Project which brings together a multidisciplinary team of investigators focused on mechanisms of IDD in children with mutations in the transcriptional regulator lysine demethylase 5c gene, KDM5C. A central function of the RFK IDDRC is to promote the substantive links between Einstein research laboratories and clinics at the Children's Evaluation and Rehabilitation Center (CERC) and the Children’s Hospital At Montefiore (CHAM). Together, our Cores and research project form a dynamic network – a community – of IDD-focused programs and practices that interlink 18 different academic departments, >100 IDDRC members and 20-plus IDD-relevant clinics at Einstein and Montefiore. The latter include 22q11.2DS, Rett and Williams syndromes, tuberous sclerosis, neurofibromatosis, West syndrome and infantile spasms, autism spectrum disorders, and a wide range of neurometabolic disorders. New initiatives moving forward at this time include our unique precision medicine/community outreach program we call Operation IDD Gene Team, our goal to fortify ties with our Einstein clinical partner (CERC and its affiliated UCEDD and LEND programs) under the umbrella of the Rose F. Kennedy Center and a heightened focus on training through our newly established T32 for IDD postdoctoral fellows.

项目摘要/摘要（总体）