Clinical Sciences Core
临床科学核心
基本信息
- 批准号:10405460
- 负责人:
- 金额:$ 58.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-04-09 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AIDS preventionAbbreviationsAcquired Immunodeficiency SyndromeAddressAgingAreaBehavioral SciencesBiologicalBiostatistics CoreCardiovascular DiseasesCaringChicagoCitiesClinicClinicalClinical DataClinical InformaticsClinical InvestigatorClinical ResearchClinical SciencesClinical assessmentsCollaborationsColorectalCommunitiesComputational TechniqueComputer AnalysisConduct Clinical TrialsDataDevelopmentDiagnosisDisciplineDiseaseEducational CurriculumElderlyElectronic Health RecordEndotheliumEpidemicFoundationsFunctional disorderFundingFutureGenitalGenitaliaGlossaryGoalsGrowthHIVHIV InfectionsHealthHealth systemHuman Subject ResearchInflammationInfrastructureInstitutionInstitutional Review BoardsLaboratoriesLesbian Gay Bisexual Transgender QueerLinkMachine LearningMentorsMissionMonitorMucous MembraneNational Heart, Lung, and Blood InstituteOlder PopulationOutcomeParticipantPatient Outcomes AssessmentsPatientsPersonsPopulationPredictive AnalyticsProcessProgram DevelopmentProviderPublic HealthReportingResearchResearch PersonnelResearch SupportResource InformaticsResourcesRiskSECTM1 geneScientistServicesSiteSleep DisordersSocial SciencesSpecial PopulationSpecimenStudy SectionTechnologyTissuesTonsilTranslational ResearchTreatment EffectivenessUnited States National Institutes of HealthUniversitiesUpdateViralViral PathogenesisVulnerable Populationsadjudicateantiretroviral therapybasecare providerscareer developmentclinical decision supportclinical phenotypeclinical practicecommunity organizationscomorbiditycomputing resourcescytokinedata warehousedigitaleHealthimplementation scienceimprovedindexinginnovationmembermicrobiomeoperationpre-exposure prophylaxisprogramsreactive hyperemiarecruitrepositoryresearch studyscreening programservice providerssuccesstool
项目摘要
PROJECT SUMMARY
THIRD COAST CFAR CORE C: CLINICAL SCIENCES CORE (CSC)
In 2017, new HIV infections in Chicago decreased somewhat, and 92% of persons diagnosed with HIV were
linked to care within 12 months of diagnosis. However, major problems remain. Only 36% of persons living with
HIV (PLWH) in 2017 were retained in care, and only 48% achieved viral suppression. In addition, successes of
antiretroviral therapy (ART) have led to a rising population of older PLWH, which has made aging-related
comorbidities a proximate threat to well-suppressed PLWH and ultimately an increasing public health challenge.
Thus, the needs to improve real-world effectiveness of treatments, as well as HIV prevention, continue. The
Clinical Sciences Core (CSC) will intensify its support of research that addresses these problems, building on
infrastructure and linkages that we have created within and between Northwestern University (NU) and the
University of Chicago (UC). An expanding group of community organization partners also increases reach to
service providers, now notably including Howard Brown Health (HBH) that has expanded sites to areas of most
need and has a long commitment to the health of the LGBTQ community in Chicago. Offering CSC expertise
and services across disciplines and institutions is central to our mission and supports the development of new
scientific partnerships. This expertise includes human subjects research on streamlining ART and studying
aging-associated comorbidities and inflammation. Our accomplished and dynamic Clinical Informatics Group
(CIG) will continue advancing researcher access to sophisticated techniques for computation, analyses of
Electronic Health Record (EHR)-derived data, and emerging digital tools for research participants. The CSC also
emphasizes disseminating research findings and best practices, as well as engaging with community-based
clinics and HIV screening programs. The long-term goal of the CSC is to significantly increase the number of
outstanding clinical investigators, and the trans-disciplinary resources available to them, in order to fuel
discoveries that will propel us towards the end of the HIV epidemic. The CSC’s specific aims to reach this goal
are to: 1) support clinical research that interacts with HIV-infected and at-risk participants, and/or obtains and
studies clinical data and specimens from them; 2) catalyze and support new research on non-AIDS
comorbidities, including clinical phenotyping and pathophysiology of inflammation and accelerated aging in HIV;
3) expand research collaborations and linkages among study participants, clinical HIV researchers, HIV care
providers, other implementation partners and trainees. In the next project period, the CSC commits to expanding
the scope and impact of research on non-AIDS comorbidities among PLWH on ART as a major contributor to
TC CFAR’s Overall aim 2. Each of the CSC specific aims contributes to Overall aim 2 on non-AIDS comorbidities,
and the intent is to increase the CSC users’ trans-disciplinary research on aging and comorbidities in HIV.
项目摘要
第三海岸CFAR核心C:临床科学核心(CSC)
2017年,芝加哥的新艾滋病毒感染人数有所下降,92%的艾滋病毒感染者是
在诊断后12个月内与护理联系起来。然而,主要问题仍然存在。只有36%的人生活在
2017年的艾滋病毒(PLWH)被保留在护理中,只有48%的人实现了病毒抑制。此外,
抗逆转录病毒疗法(ART)导致老年艾滋病毒携带者人数增加,这使得与衰老有关的
合并症是对受到良好抑制的PLWH的直接威胁,并最终成为日益严重的公共卫生挑战。
因此,需要继续提高治疗的实际效果以及艾滋病毒预防。的
临床科学核心(CSC)将加强对解决这些问题的研究的支持,
我们在西北大学(NU)内部和之间创建的基础设施和联系
芝加哥大学(UC)。不断扩大的社区组织合作伙伴群体也增加了对
服务提供商,现在特别包括霍华德布朗健康(HBH),已扩大网站的地区,
需要并长期致力于芝加哥LGBTQ社区的健康。提供CSC专业知识
跨学科和机构的服务是我们使命的核心,并支持新的
科学伙伴关系。该专业知识包括人类受试者研究简化ART和研究
与衰老相关的合并症和炎症。我们富有成就和活力的临床信息学团队
(CIG)将继续推动研究人员获得复杂的计算、分析技术
电子健康记录(EHR)衍生数据,以及研究参与者的新兴数字化工具。CSC还
强调传播研究成果和最佳做法,并与社区
诊所和艾滋病毒筛查项目。CSC的长期目标是大幅增加
优秀的临床研究者,以及他们可用的跨学科资源,以推动
这些发现将推动我们走向艾滋病流行的终结。CSC的具体目标是实现这一目标
1)支持与艾滋病毒感染者和高危参与者互动的临床研究,和/或获得和
研究临床数据和样本; 2)促进和支持非艾滋病的新研究
合并症,包括HIV的临床表型和炎症的病理生理学以及加速老化;
3)扩大研究参与者、临床艾滋病毒研究人员、艾滋病毒护理人员之间的研究合作和联系
提供者、其他执行伙伴和受训人员。在下一个项目期间,CSC承诺扩大
艾滋病病毒感染者非艾滋病合并症研究的范围和影响,
TC CFAR的总体目标2. CSC的每一个具体目标都有助于实现关于非艾滋病合并症的总体目标2,
其目的是增加CSC用户对艾滋病毒老化和合并症的跨学科研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Babafemi O Taiwo其他文献
Antiretroviral Therapy: Darunavir: An Overview of an HIV Protease Inhibitor Developed to Overcome Drug Resistance
抗逆转录病毒疗法:达芦那韦:为克服耐药性而开发的 HIV 蛋白酶抑制剂概述
- DOI:
- 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
Babafemi O Taiwo;Charles B. Hicks - 通讯作者:
Charles B. Hicks
Babafemi O Taiwo的其他文献
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{{ truncateString('Babafemi O Taiwo', 18)}}的其他基金
Expansion of SARS-CoV-2 Testing Supplement, Chicago Clinical Trials Unit
芝加哥临床试验中心 SARS-CoV-2 检测补充的扩展
- 批准号:
10166472 - 财政年份:2020
- 资助金额:
$ 58.53万 - 项目类别:
Intensive Combination Approach to Rollback the Epidemic (iCARE) in Nigerian Adolescents
尼日利亚青少年抗击疫情的强化组合方法 (iCARE)
- 批准号:
10600549 - 财政年份:2018
- 资助金额:
$ 58.53万 - 项目类别:
Intensive Combination Approach to Rollback the Epidemic (iCARE) in Nigerian Adolescents
尼日利亚青少年抗击疫情的强化组合方法 (iCARE)
- 批准号:
10228282 - 财政年份:2018
- 资助金额:
$ 58.53万 - 项目类别:
Intensive Combination Approach to Rollback the Epidemic (iCARE) in Nigerian Adolescents
尼日利亚青少年抗击疫情的强化组合方法 (iCARE)
- 批准号:
10468148 - 财政年份:2018
- 资助金额:
$ 58.53万 - 项目类别:
Intensive Combination Approach to Rollback the Epidemic (iCARE) in Nigerian Adolescents
尼日利亚青少年抗击疫情的强化组合方法 (iCARE)
- 批准号:
10252943 - 财政年份:2018
- 资助金额:
$ 58.53万 - 项目类别:
Expanded Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria
扩大多学科神经艾滋病研究培训以改善尼日利亚的艾滋病毒治疗结果
- 批准号:
10462158 - 财政年份:2013
- 资助金额:
$ 58.53万 - 项目类别:
Expanded Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria
扩大多学科神经艾滋病研究培训以改善尼日利亚的艾滋病毒治疗结果
- 批准号:
9903485 - 财政年份:2013
- 资助金额:
$ 58.53万 - 项目类别:
Expanded Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria
扩大多学科神经艾滋病研究培训以改善尼日利亚的艾滋病毒治疗结果
- 批准号:
10349429 - 财政年份:2013
- 资助金额:
$ 58.53万 - 项目类别:
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