Expanded Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria

扩大多学科神经艾滋病研究培训以改善尼日利亚的艾滋病毒治疗结果

• 批准号: 9903485
• 负责人: Babafemi O Taiwo
• 金额: $ 29.9万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-05 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9903485
• 关键词: Address; Africa; Assessment tool; Biological; Brain Diseases; Cerebrovascular Disorders; Clinical; Clinical Research; Clinical Sciences; Communicable Diseases; Communities; Consequences of HIV; Discipline; Disclosure; Doctor of Philosophy; Drug resistance; Extramural Activities; Fellowship; Funding; Genomics; HIV; Healthcare Systems; Impairment; Infrastructure; Knowledge; Lead; Manuscripts; Master of Science; Measurement; Mental Depression; Mental Health; Mental disorders; Mentors; Neurocognitive; Neurologic; Neurologist; Neurology; Neuropsychology; Nigeria; Nigerian; Observational Study; Outcome; Pharmacology; Physicians; Psyche structure; Psychiatric Nursing; Psychiatrist; Psychologist; Quality of life; Research; Research Personnel; Research Support; Research Training; Residual state; Shoulder; Standardization; Substance abuse problem; Time; Toxic effect; Training; Translational Research; Universities; Writing; clinical investigation; co-infection; collaboratory; implementation science; improved; laboratory experience; medical specialties; multidisciplinary; neuroAIDS; neurobehavioral; optimal treatments; post-doctoral training; programs; radiologist; social stigma

Nigeria has a high burden of HIV-related brain disorders (NeuroAIDS), including mental health disorders and neurocognitive or neurological impairment. Over the last 4 years, the Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria (D43TW009608-03) has developed three NeuroAIDS research cores with 10 investigators, two observational studies, and trained research support staff, including 3 psychometricians at the University of Ibadan (UI). Reviewing our progress with our Nigerian partners, we have identified residual gaps, which we propose to address by doubling the number of investigators and psychometricians through the Expanded Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria. In the Mental Health Core, we will: 1) add implementation science by providing PhD training to a physician who excelled in the Northwestern University Master of Science in Clinical Investigation (MSCI) program, and 2) provide focused didactics and mentored research for 3 clinical psychologists/mental health nurses, thus expand UI's community of NeuroAIDS researchers to include these disciplines that are currently unrepresented but are key components of Nigeria's mental healthcare system. In the Translational and Clinical Sciences Core, we will provide intensive laboratory training for a pharmacology PhD candidate, postdoctoral training to a virologist, MSCI to a neurology/infectious diseases physician, and specialty clinical research training to a radiologist, all with integrated mentored research. In the Neuropsychological Infrastructure Core, we will provide postdoctoral neuropsychology fellowships for psychiatrists or neurologists to produce two experts who will train new psychometricians, as well as lead already-trained psychometricians and biostatisticians to create transformative capacity for neuropsychological assessment and analytics locally. Over half of each trainee's time will be in UI. The aggregated capacity of the cores will build into a research program equipped to lead in: 1) Mental Health Research- e.g., depression, stigma, disclosure, quality of life and, substance abuse; and 2) Translational and Clinical Research- e.g. understanding the biologic basis and optimal treatment of HAND; and unraveling the contribution of CNS compartmentalization, ART toxicity, drug resistance, cerebrovascular diseases, genomics, and co-infections to NeuroAIDS. The program will be distinguished by neuropsychological assessment expertise and locally standardized assessment instruments with appropriate norms to provide reliable and valid measurement of neurobehavioral consequences of HIV and its treatments in Nigeria. Training will be expanded further, knowledge disseminated, and ideas cross- fertilized through forums that we created in UI, including a monthly NeuroAIDS Collaboratory and a biannual NeuroAIDS Week with about 150 attendees/year. Manuscript writing and grantsmanship mentoring will prepare the trainees to become funded independent investigators. In 5 years, UI's multidisciplinary researchers will shoulder NeuroAIDS research in Nigeria with extramural funding, impacting the whole of Africa.

尼日利亚有很高的艾滋病毒相关的脑部疾病负担（神经艾滋病），包括精神健康障碍和 神经认知或神经损伤。在过去的4年里，多学科神经艾滋病研究 尼日利亚改善艾滋病毒治疗效果的培训（D43 TW 009608 -03）已经开展了三项神经艾滋病研究 核心，10名研究者，2项观察性研究，以及经过培训的研究支持人员，包括3名 伊巴丹大学（UI）的心理测量学家。回顾我们与尼日利亚合作伙伴取得的进展， 我们建议通过将调查员人数增加一倍， 通过扩大的多学科神经艾滋病研究培训，以改善艾滋病毒 尼日利亚的成果。在心理健康核心，我们将：1）通过提供博士学位来增加实施科学 培训一名在西北大学临床研究理学硕士中表现出色的医生 （MSCI）计划，以及2）为3名临床心理学家/心理医生提供重点教学和指导研究 健康护士，从而扩大了UI的神经艾滋病研究人员社区，包括这些学科， 目前没有代表，但尼日利亚的精神保健系统的关键组成部分。沿平移 和临床科学核心，我们将为药理学博士候选人提供密集的实验室培训， 病毒学家博士后培训，神经学/传染病医生MSCI，以及专业临床 研究培训到放射科医生，所有这些都有综合的指导研究。在神经心理学 基础设施核心，我们将为精神科医生或神经科医生提供博士后神经心理学奖学金 培养两名专家，他们将培训新的心理测量师，并领导已经接受过培训的心理测量师 和生物统计学家，为当地的神经心理学评估和分析创造变革能力。 每个学员一半以上的时间将在UI。核心的聚合容量将构建成一个研究 有能力领导以下领域的项目：1）心理健康研究-例如，抑郁症，污名，揭露，生活质量 和，药物滥用;和2）转化和临床研究-例如，了解生物学基础， HAND的最佳治疗;以及揭示CNS区室化，ART毒性，药物 耐药性、脑血管疾病、基因组学和NeuroAIDS的合并感染。该计划将 以神经心理学评估专业知识和当地标准化评估工具而闻名 适当的规范，以提供可靠和有效的衡量艾滋病毒的神经行为后果 以及它在尼日利亚的治疗。将进一步扩大培训，传播知识， 通过我们在UI中创建的论坛，包括每月一次的NeuroAIDS合作实验室和一年两次的 神经艾滋病周，每年约有150人参加。写作和写作指导将准备 学员成为受资助的独立调查员。在5年内，UI的多学科研究人员将 在尼日利亚的神经艾滋病研究中获得校外资助，影响了整个非洲。