Expanded Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria

尼日利亚的艾滋病毒相关脑部疾病(神经艾滋病)负担很重，包括精神健康障碍和 神经认知或神经功能障碍。在过去的4年里，多学科的神经艾滋病研究 尼日利亚改善艾滋病毒结果的培训(D43TW009608-03)发展了三项神经艾滋病研究 核心有10名调查人员、两项观察性研究和训练有素的研究支助人员，其中包括3名 伊巴丹大学(UI)的心理测量学家。与我们的尼日利亚伙伴一起回顾我们的进展，我们有 找出了剩余的差距，我们建议通过增加一倍的调查人员和 心理测量师通过扩大多学科神经艾滋病研究培训来改善艾滋病毒 在尼日利亚取得的成果。在心理健康核心，我们将：1)通过提供博士学位来增加实施科学 培养一名西北大学临床调查理学硕士的优秀医师 (MSCI)计划，以及2)为3名临床心理学家/精神科医生提供有针对性的教学和指导研究 健康护士，从而扩大了UI的神经艾滋病研究人员社区，将这些学科包括在内 目前无人任职，但却是尼日利亚精神卫生保健系统的关键组成部分。在翻译中 和临床科学核心，我们将为药理学博士生提供密集的实验室培训， 对病毒学家的博士后培训，对神经病学/传染病内科医生的MSCI培训，以及对专科临床的培训 对放射科医生进行研究培训，所有这些都是有指导的综合研究。在神经心理学中 基础设施核心，我们将为精神病学家或神经学家提供博士后神经心理学奖学金 产生两名专家，他们将培训新的心理测量师，以及领导已经接受过培训的心理测量师 以及生物统计学家，为当地的神经心理评估和分析创造变革性能力。 每个实习生一半以上的时间将在用户界面中。这些核心的聚合能力将纳入研究 1)心理健康研究--例如，抑郁、耻辱、表露、生活质量 和，物质滥用；和2)翻译和临床研究--例如，了解生物基础和 手部的最佳治疗；并解开中枢神经系统分区、ART毒性、药物的贡献 抵抗力、脑血管疾病、基因组学和神经艾滋病的混合感染。该计划将是 以神经心理评估专业知识和当地标准化评估工具而闻名 具有适当的规范，为艾滋病毒的神经行为后果提供可靠和有效的测量 以及它在尼日利亚的治疗。培训将进一步扩大，知识传播，思想交叉- 通过我们在UI中创建的论坛受精，包括每月一次的神经艾滋病合作实验室和一年两次的 每年约有150人参加的神经艾滋病周。手稿写作和资助性辅导将准备 受训人员将成为受资助的独立调查人员。在5年内，UI的多学科研究人员将 在尼日利亚开展肩部神经艾滋病研究，获得了外部资金，影响了整个非洲。

Nigeria has a high burden of HIV-related brain disorders (NeuroAIDS), including mental health disorders and neurocognitive or neurological impairment. Over the last 4 years, the Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria (D43TW009608-03) has developed three NeuroAIDS research cores with 10 investigators, two observational studies, and trained research support staff, including 3 psychometricians at the University of Ibadan (UI). Reviewing our progress with our Nigerian partners, we have identified residual gaps, which we propose to address by doubling the number of investigators and psychometricians through the Expanded Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria. In the Mental Health Core, we will: 1) add implementation science by providing PhD training to a physician who excelled in the Northwestern University Master of Science in Clinical Investigation (MSCI) program, and 2) provide focused didactics and mentored research for 3 clinical psychologists/mental health nurses, thus expand UI's community of NeuroAIDS researchers to include these disciplines that are currently unrepresented but are key components of Nigeria's mental healthcare system. In the Translational and Clinical Sciences Core, we will provide intensive laboratory training for a pharmacology PhD candidate, postdoctoral training to a virologist, MSCI to a neurology/infectious diseases physician, and specialty clinical research training to a radiologist, all with integrated mentored research. In the Neuropsychological Infrastructure Core, we will provide postdoctoral neuropsychology fellowships for psychiatrists or neurologists to produce two experts who will train new psychometricians, as well as lead already-trained psychometricians and biostatisticians to create transformative capacity for neuropsychological assessment and analytics locally. Over half of each trainee's time will be in UI. The aggregated capacity of the cores will build into a research program equipped to lead in: 1) Mental Health Research- e.g., depression, stigma, disclosure, quality of life and, substance abuse; and 2) Translational and Clinical Research- e.g. understanding the biologic basis and optimal treatment of HAND; and unraveling the contribution of CNS compartmentalization, ART toxicity, drug resistance, cerebrovascular diseases, genomics, and co-infections to NeuroAIDS. The program will be distinguished by neuropsychological assessment expertise and locally standardized assessment instruments with appropriate norms to provide reliable and valid measurement of neurobehavioral consequences of HIV and its treatments in Nigeria. Training will be expanded further, knowledge disseminated, and ideas cross- fertilized through forums that we created in UI, including a monthly NeuroAIDS Collaboratory and a biannual NeuroAIDS Week with about 150 attendees/year. Manuscript writing and grantsmanship mentoring will prepare the trainees to become funded independent investigators. In 5 years, UI's multidisciplinary researchers will shoulder NeuroAIDS research in Nigeria with extramural funding, impacting the whole of Africa.