The University of Southern California and Buck Institute Nathan Shock Center

证据摘要 我们的内森休克中心（NSC）的卓越（P30 AG 068345）提供访问老年科学技术， 研究培训，并为美国各地的老年科学家提供研究支持。NSC专注于基础 生物学的老化，从而使用各种方法和技术，以促进我们的理解， 老年科学我们的NSC的用户研究各种生物变量的分子，细胞，组织，器官， 有机体水平。除了老年科学界要求利用我们的大量资源外， Geroscience技术核心（GTC）和我们南加州大学NSC教师的专业知识，我们经常被问到我们是否可以 将这些强大的研究与显微镜和视觉测量相结合。目前，高分辨率和 多重成像不是我们国家安全中心提供的一项服务，它代表了一个未得到满足的社区需求 老年科学研究者们使用我们的国家安全委员会核心。为了提高显微镜的可用性 为在南加州大学进行的老年科学研究项目的技术，我们建议购买蔡司LSM 980共聚焦显微镜-目前最快的超分辨率系统，能够获得广泛的 活样本的分子、细胞、组织和有机体细节的范围。这些措施对于 我们有能力充分了解衰老和年龄相关疾病的基础， 程度.我们的行政补充将建立一个强大的新工具，在武库的技术， 老年科学技术核心（GTC）。这些新技术为南加州大学带来了意想不到的机会 提高成像研究能力，提供给我们在伦纳德国家科学中心服务的所有老年科学用户 南加州大学戴维斯老年学学院。因此，我们的行政补充将大大影响老年科学 全国性的

ABSTRACT OF SUPPLEMENT Our Nathan Shock Center (NSC) of Excellence (P30 AG068345) provides access to geroscience technology, research training, and research support for geroscientists across the United States. NSCs focus on the basic biology of aging and thus use a variety of methodologies and technologies to advance our understanding of geroscience. Users of our NSC study a variety of biological variables at the molecular, cell, tissue, organ, and organismal levels. In addition to the requests from the geroscience community to use the vast resources of our Geroscience Technology Core (GTC) and the expertise of our NSC faculty at USC, we are often asked if we can couple these powerful studies with microscopy and visual measurements. Currently, high resolution and multiplex imaging is not a service that is available at our NSC and represents an unmet need of the community of geroscience researchers that utilize our NSC cores. In order to advance the availability of microscopy technology for the geroscience research projects performed at USC, we propose the purchase of the Zeiss LSM 980 confocal microscope - currently the fastest super-resolution system that enables the acquisition of a wide range of molecular, cellular, tissue, and organismal details of live samples. These measures are essential to our ability to fully understand the underlying basis of aging and age-related diseases across all hierarchical levels. Our administrative supplement will establish a powerful new tool in the arsenal of technologies in the Geroscience Technology Core (GTC). These new technologies represent an unexpected opportunity for USC to advance the imaging research capacity, available to all geroscience users of our NSC services at the Leonard Davis School of Gerontology at USC. As such, our administrative supplement will greatly impact geroscience nation-wide.