The University of Southern California and Buck Institute Nathan Shock Center

南加州大学和巴克研究所内森休克中心

• 批准号: 10649615
• 负责人: Sean P CURRAN
• 金额: $ 92.33万
• 依托单位: BUCK INSTITUTE FOR RESEARCH ON AGING
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10649615
• 关键词: Acceleration; Aging; Air Pollution; Apoptosis; Basic Science; Bioinformatics; Biological Assay; Biological Models; Biology of Aging; Birth; California; Cell Aging; Cells; Centers of Research Excellence; Chronic Disease; Collaborations; Collection; Communities; Cultured Cells; Data; Disease; Doctor of Philosophy; Education; Elderly; Ensure; Environment; Faculty; Female; Financial Support; Fishes; Funding; Funding Mechanisms; Future; Generations; Genes; Genomics; Geroscience; Goals; Health; Health and Retirement Study; Human; Human Resources; Infrastructure; Institution; Intervention; Joints; Leadership; Longevity; Medicine; Mentors; Mentorship; Metabolism; Methodology; Methods; Methylation; Mitochondria; Modeling; Mus; Nature; Organ; Organism; Organoids; Phenotype; Pilot Projects; Prevention; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Sampling; Scanning; Scheme; Shock; Technology; Tissues; Training; Translations; United States National Institutes of Health; Universities; Yeasts; design; experience; fly; gene interaction; innovation; model organism; next generation; phenomenological models; programs; reproductive senescence; research and development; sabbatical; senescence; single cell analysis; single cell technology; technology platform; therapy development; training opportunity; translational genomics; verdin photosensitizer; voucher

ABSTRACT- USC-Buck Institute Nathan Shock Center Overall The biology of aging field is at an inflection point; driven by 30 years of discoveries that have revealed mechanisms of aging and lifespan determination. Until recently, these studies were deemed phenomenological, but geroscientists are now transforming the way we approach the study of chronic diseases and the practice of medicine itself. For this transformation to be sustainable, the basic biology of aging field must expand. Critical for this expansion, is the training of the next generation of geoscientists. Here we present an innovative program of activities, with a strong emphasis on training, designed to overcome these challenges. This includes many Research Sabbaticals, a pilot project scheme and a voucher funding mechanism to open outside investigators to an unmatched technology platform for aging research.

摘要-南加州大学巴克研究所内森休克中心整体 衰老领域的生物学正处于一个转折点; 30年来的发现揭示了 衰老和寿命决定的机制。直到最近，这些研究被认为是 但老年科学家现在正在改变我们研究慢性病的方式 以及医学实践本身。为了使这种转变持续下去，衰老领域的基础生物学 必须扩大。这种扩张的关键是下一代地球科学家的培训。我们在此报告了 一个创新的活动方案，重点是培训，旨在克服这些问题， 挑战这包括许多研究休假，试点项目计划和凭证资金 该机制旨在向外部调查人员开放一个无与伦比的老龄化研究技术平台。