USC-Buck Geroscience Training in the Biology of Aging

南加州大学巴克分校老年科学衰老生物学培训

• 批准号: 10659256
• 负责人: Sean P CURRAN
• 金额: $ 66.49万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659256
• 关键词: Biology of Aging; Geroscience; Training

Abstract This is a renewal application for the USC-Buck Geroscience Training Program in the Biology of Aging T32 Training Grant which was first funded as of May 1st, 2016. The training program is an unique cooperative venture of the University of Southern California's Leonard Davis School of Gerontology (USC) and the Buck Institute for Research on Aging (Buck). In 2014, in a truly joint venture, we created the very first dedicated Biology of Aging Ph.D. program in the USA. Students take courses at both institutions, many in person but also in a fully interactive on-line format and undertake first-year lab. rotations at both campuses before selecting a mentor and lab. at USC or the Buck. As we come to the end of the fourth year of our T32 grant we are pleased to report that our young PhD program is comprised of a current PhD student body of 41 PhD candidates. Although our inaugural admission to the program was in 2014, we have already graduated 7 PhD students and expect another 6-7 to graduate with their doctoral degrees by the end of the current grant period – average time to degree completion is 5 years. Thirteen predoctoral trainees and six postdoctoral trainees have been supported by our T32 grant. The goals of our Biology of Aging program are as follows: 1) To train pre-doctoral and post-doctoral researchers who will become leaders in the biology of aging field. Our training encompasses biochemistry, molecular biology, molecular genetics, physiology, neurobiology, computational biology, immunology, and pathology; 2) To enable students and post-doctoral fellows to become experts in the theory and methods of one specific area of biological research, but also enable them to incorporate methods and approaches from other disciplines of cutting-edge areas of aging research; 3) To provide our students and post- doctoral fellows with training which incorporates familiarity with the theory, methods, and data of the multiple aging disciplines that are essential to dealing with national issues arising from the aging of the population (e.g. susceptibility to, or poor outcomes from, viral diseases such as COVID-19) as well as insuring individuals a long, healthy life: 4) To provide predoctoral and postdoctoral trainees with structured curriculum and research experiences that lead to mastery of the knowledge, methods, analytic approaches, and theory of the gerosciences; 5) To provide both predoctoral and postdoctoral trainees structured exposures that allow them to gain understanding of the knowledge, methods, and theory of other relevant gerontological disciplines (sociology, psychology, public policy, elder-law, elder-economics, etc.) through scheduled activities such as the weekly Multidisciplinary Research Colloquium in Aging, and courses, such as GERO 592 – “Multidisciplinary Perspectives on Current Research in Gerontology.”; 6) To develop demonstrable research competence, emphasizing ethics, the responsible conduct of research, and methods for enhancing reproducibility through participation in research projects with mentors and development of independent research projects. Through these training goals, we expect our trainees to become leaders in the next generation of aging researchers.

摘要 这是USC-Buck老年科学培训计划的更新申请，该计划涉及衰老生物学T32 培训补助金于2016年5月1日首次资助。该培训项目是一个独特的合作项目， 南加州大学伦纳德戴维斯老年学学院（南加州大学）和巴克 老年研究所（巴克）。2014年，在一个真正的合资企业中，我们创建了第一个专门的 衰老生物学博士在美国的节目。学生们在这两个机构上课，许多人亲自上课， 并进行第一年实验。在两个校区轮换之前， 导师和实验室在南加州大学或巴克。当我们即将结束我们的T32赠款的第四年，我们很高兴 报告说，我们年轻的博士课程是由41名博士候选人目前的博士生身体。 虽然我们的首届录取该计划是在2014年，我们已经毕业7博士生， 预计另外6-7人将在目前的资助期结束时获得博士学位-平均时间 完成学位是5年。13名博士前学员和6名博士后学员已被 由我们的T32资助。我们的衰老生物学计划的目标如下：1）培养博士前 和博士后研究人员，他们将成为衰老生物学领域的领导者。我们的培训包括 生物化学，分子生物学，分子遗传学，生理学，神经生物学，计算生物学， 免疫学和病理学; 2）使学生和博士后研究员成为理论专家 和方法的一个特定领域的生物学研究，而且还使他们能够纳入方法， 从老龄化研究的前沿领域的其他学科的方法; 3）为我们的学生和后， 博士研究员与培训，其中包括熟悉的理论，方法，和数据的多个 处理人口老龄化引起的国家问题所必需的老龄化学科（例如， 对COVID-19等病毒性疾病的易感性或不良结果）以及投保个人 健康长寿：4）为博士前和博士后学员提供结构化的课程和研究 经验，导致掌握的知识，方法，分析方法，和理论的 5）为博士前和博士后学员提供结构化的接触，使他们能够 了解其他相关老年学学科的知识、方法和理论 （社会学、心理学、公共政策、老年人法、老年人经济学等）通过预定的活动，如 每周一次的老龄问题多学科研究座谈会和课程，如热罗592 -“多学科 对当前老年学研究的展望。6)发展可证明的研究能力， 强调道德，负责任的研究行为，以及通过以下方式提高可重复性的方法 与导师一起参与研究项目，并开发独立的研究项目。通过 这些培训目标，我们期望我们的学员成为下一代衰老研究人员的领导者。

项目成果

Proteome plasticity in response to persistent environmental change.

• DOI: 10.1016/j.molcel.2021.06.028
• 发表时间: 2021-08-19
• 期刊: Molecular cell
• 影响因子: 16
• 作者: Domnauer M;Zheng F;Li L;Zhang Y;Chang CE;Unruh JR;Conkright-Fincham J;McCroskey S;Florens L;Zhang Y;Seidel C;Fong B;Schilling B;Sharma R;Ramanathan A;Si K;Zhou C
• 通讯作者: Zhou C

Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model.

促卵泡激素受体单倍体不足模型中缺乏加速卵巢老化。

• DOI: 10.1016/j.tma.2023.01.001
• 发表时间: 2023
• 期刊: Translational medicine of aging
• 作者: Mehalko,Kristen;Kim,Minhoo;Paye,Sanjana;Koh,Kelly;Lu,RyanJ;Benayoun,BéréniceA
• 通讯作者: Benayoun,BéréniceA

Regional variation in U.S dementia trends from 2000-2012.

• DOI: 10.1016/j.ssmph.2022.101164
• 发表时间: 2022-09
• 期刊: SSM-POPULATION HEALTH
• 影响因子: 4.7
• 作者: Ailshire, Jennifer A.;Walsemann, Katrina M.;Fisk, Calley E.
• 通讯作者: Fisk, Calley E.

Bacterial diets differentially alter lifespan and healthspan trajectories in C. elegans.

• DOI: 10.1038/s42003-020-01379-1
• 发表时间: 2020-11-06
• 期刊: Communications biology
• 影响因子: 5.9
• 作者: Stuhr NL;Curran SP
• 通讯作者: Curran SP

Prenatal and early life exposure to air pollution induced hippocampal vascular leakage and impaired neurogenesis in association with behavioral deficits.

• DOI: 10.1038/s41398-018-0317-1
• 发表时间: 2018-11-29
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Woodward NC;Haghani A;Johnson RG;Hsu TM;Saffari A;Sioutas C;Kanoski SE;Finch CE;Morgan TE
• 通讯作者: Morgan TE