Fetal Alcohol Spectrum Disorders in Adults: Health and Neurobehavior

摘要 最近的流行病学研究表明，胎儿酒精谱系障碍(FASD)可能有 人口中高达5%的流行率(5月等人)2014)；然而，它很少在 成年期和没有公认的治疗方案，因为尽管几十年来 产前酒精暴露(PAE)对成人FASD影响的科学研究 几乎是未知的。缺乏准确的信息对这些人来说是毁灭性的，他们的 对于遇到受影响个人的专业人士来说，这是一个令人沮丧的家庭和来源。 尽管神经发育缺陷可能是持续性的，但如果没有关于 与PAE、照顾者、卫生保健专业人员相关的心理和身体健康问题 政策制定者无法做出明智的决定、准确的诊断、提供护理或 分配资源。在CIFASD提供的资源支持下，目前的项目是 唯一有资格解决这一赤字并实现以下具体目标：1)建立 登记了500名30岁以上已知酒精接触者/FASD 诊断或谁是匹配的对照组，谁将对健康调查做出反应，谁将 可用于未来的研究；2)在受影响的个人(Fas或FASD)和对照(120来自 亚特兰大和西雅图的120人)，以深入评估支持成年人的地区的现状 身体和社会功能，目标是完善这个年龄段FASD的诊断标准 并确定与PAE相关的残疾的持久性和严重程度。这 活动将包括检查畸形，提取医疗记录，物质 使用(自我报告和生物样本)、认知和心理健康以及社会因素 这可能有助于结果和残疾状况。最后，3)评估免疫状态(在 与Weinberg博士合作)，并确定与健康指标相关的结果。

Abstract Recent epidemiological studies suggest that Fetal Alcohol Spectrum Disorder (FASD) may have a prevalence of up to 5% in the population (May, et al. 2014); however, it is rarely diagnosed in adulthood and there are no recognized treatment protocols because, despite decades of research on the effects of prenatal alcohol exposure (PAE), scientific study of adults with FASD is almost unknown. This lack of accurate information is devastating for these individuals, their families and a source of frustration for professionals who encounter affected individuals. Although neurodevelopmental deficits may be persistent, without accurate information about mental and physical health problems associated with PAE, caregivers, health care professionals and policy makers cannot make informed decisions, diagnose accurately, provide care or allocate resources. Supported by the resources provided by CIFASD, the current project is uniquely qualified to address this deficit and carry out the following Specific Aims: 1) Establish a registry of 500 individuals, older than 30 years of age, with known alcohol exposure/FASD diagnosis or who are matched controls who will respond to a health survey, and who will be available for future studies; 2) in affected individuals (FAS or FASD) and controls (120 from Atlanta and 120 from Seattle), to evaluate in depth current status in areas supporting adults physical and social functioning with the goal of refining diagnostic criteria for FASD in this age group and determining the persistence and severity of disability associated with PAE. This activity will include examination of dysmorphology, abstraction of medical records, substance use (self-report and biological samples), cognition and mental health as well as social factors that might contribute to outcomes and disability status. Finally, 3) to assess immune status (in collaboration with Dr. Weinberg) and identify outcomes associated with health indicators.