Fetal Alcohol Spectrum Disorders in Adults: Health and Neurobehavior

成人胎儿酒精谱系障碍：健康和神经行为

• 批准号: 10413275
• 负责人: Claire D. Coles
• 金额: $ 14.08万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413275
• 关键词: Address; Adult; Affect; Age; Age-Years; Alcohols; Anxiety; Area; Autoimmune; Behavior; Behavioral; Biological; Blood specimen; Cardiovascular system; Caregivers; Caring; Characteristics; Child; Clinical; Cognition; Collaborations; Data; Development; Diabetes Mellitus; Diagnosis; Diagnostic; Disease; Dysmorphology; Endocrine; Enrollment; Family; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal alcohol effects; Frustration; Future; Goals; Health; Health Professional; Health Status; Health Surveys; Health behavior; High Prevalence; Immune; Impaired cognition; Individual; Investigation; Life; Life Cycle Stages; Measures; Medical Records; Mental Depression; Mental Health; Metabolic; Metabolic syndrome; Natural History; Neurodevelopmental Deficit; Organism; Outcome; Patient Self-Report; Pattern; Personal Satisfaction; Phenotype; Physical Function; Physiological; Physiology; Policy Maker; Population; Prevalence; Public Health; Recording of previous events; Registries; Reporting; Research; Research Personnel; Resources; Risk; Sampling; Severities; Site; Social Functioning; Socioeconomic Status; Source; Stress; Substance abuse problem; Surveys; Thyroid Gland; Treatment Protocols; Vision; Vulnerable Populations; Work; accurate diagnosis; age group; alcohol exposure; cognitive function; cohort; data sharing; disability; disorder control; epidemiology study; fetal diagnosis; fetal programming; follow-up; functional outcomes; health data; immune function; immunological status; neurobehavior; physical conditioning; prevent; resilience; social deficits; social factors; stress reactivity; substance use

The 5-year award, for which this would be an administrative supplement in response to NOT-AA-20-011, focuses on the impact of prenatal alcohol exposure (PAE) on physical and mental health within the context of social and environmental factors that may contribute to outcomes in adulthood. There are two important, and related, reasons to include attention to COVID-19 and the medical and social implications of the pandemic in this ongoing study of alcohol-affected adults. First, there is evidence that the adults in the longitudinal cohorts being followed in Atlanta and Seattle are particularly vulnerable to the impact of the pandemic. Second, given this vulnerability, the pandemic represents a historic threat to the validity of study outcomes that must be addressed. In the parent study, 500 volunteers, half from each site will be seen for Tier 1, that includes remote collection of self-reported health and demographic information. In Tier 2, 240 individuals are being seen for more comprehensive assessment of health risk, immune status, neurocognition, and social functioning. To date, 226 individuals have completed Tier 1. Preliminary data, from Years 1-3, indicates that, in these samples, PAE is associated with higher risk for cardiovascular compromise, intellectual and social dysfunction, and higher rates of substance use. The majority of individuals in these cohorts are from populations that have been identified nationally as more impacted by COVID-19 infection and mortality (i.e., African-American; Native-American) and many in these groups are highly anxious about the effects of the virus. Given these factors, we will collect information on the impact of COVID-19 on health (e.g..,medical records), social outcomes (e.g., job loss, homelessness), and mental health status as well as substance use. COVID-relevant questionnaires will be administered remotely to both those who have previously participated and to future participants allow measurement of the effects of the pandemic on these outcomes. In Atlanta only, an extra tube of blood will be obtained during existing blood draw for antibody testing. Finally, we will employ the National Death Index (NDI) to determine mortality rates over the past 10 years in the parent cohorts from which these samples are being drawn, allowing an estimate of mortality in these 902 individuals who have previously participated in research. We anticipate that individuals with PAE will show more impact on health during this emergency and they may have a higher mortality rate than nonexposed individuals. Further, we anticipate that PAE will be associated with greater anxiety related to COVID-Exposure and increased substance use. We also hypothesize that social and environmental factors will contribute to the severity of effects.

5年奖励，这将是对NOT-AA-20-011的行政补充， 关注产前酒精暴露（PAE）对身心健康的影响， 社会和环境因素可能会影响成年后的结果。有两个重要的， 和相关的原因，包括关注COVID-19和医疗和社会影响， 在这项正在进行的对受酒精影响的成年人的研究中，首先，有证据表明， 在亚特兰大和西雅图跟踪的纵向队列特别容易受到 流行病其次，鉴于这种脆弱性，这场大流行对研究的有效性构成了历史性威胁 必须解决的结果。在母研究中，500名志愿者（每个研究中心各一半）将被观察 第1级，包括远程收集自我报告的健康和人口统计信息。在第二层，240 人们正在接受更全面的健康风险评估，免疫状态， 神经认知和社会功能。到目前为止，已有226人完成了第1级。初步数据， 表明，在这些样本中，PAE与心血管疾病风险较高相关 妥协，智力和社会功能障碍，以及更高的物质使用率。大多数 这些队列中的个体来自全国范围内被确定为受 COVID-19感染和死亡率（即，非洲裔美国人;土著美国人）和许多这些群体 对病毒的影响感到非常焦虑鉴于这些因素，我们将收集有关 COVID-19对健康的影响（例如，医疗记录），社会结果（例如，失业、无家可归），以及 精神健康状况以及物质使用。新冠病毒相关问卷将在 远程连接到先前参与者和未来参与者， 大流行对这些结果的影响。仅在亚特兰大，将获得额外的一管血液 在现有的抽血进行抗体检测期间。最后，我们将使用国家死亡指数（NDI） 以确定这些样本所来自的父母队列在过去10年中的死亡率， 绘制，允许在这902个人谁以前参加了死亡率的估计， research.我们预计，在这一紧急情况下，患有PAE的个人将对健康产生更大的影响。 他们的死亡率可能比未接触过的人高。此外，我们预计， 将与与COVID暴露相关的更大焦虑和物质使用增加相关。我们也 假设社会和环境因素将导致影响的严重性。