Comprehensive Training Program in Oral Biology

联系PD/PI：Lemos，Jose A 摘要 为了响应NIDCR的PAR-20-056，开发和增强牙科、口腔和颅面 研究人员，T90/R90口腔生物学综合培训计划的建议。该提案 建立在29年的经验，在大学的高效T32和T90/R90培训计划 佛罗里达牙科学院（UFCD），并将提供广泛的广度和深度的培训，以基本和 NIDCR指定为高优先级的多个领域的临床科学家。科学领域 在口腔生物学综合培训计划包括，但不限于， 人类微生物组，口腔传染病，口腔和全身健康之间的机械联系， 病毒学，唾液腺生物学，自身免疫，骨生物学，头颈癌，计算 生物学、生物医学工程和干细胞生物学。为了实现我们的目标，一个有成就的团队 基础和临床研究人员已经聚集在一起，提供一套广泛的培训经验， 与口腔健康和疾病直接相关的生物医学科学。成熟的跨学科 将利用UFCD和UF医学院的研究培训计划，特别是 强调跨学科博士课程在生物医学科学和UF临床和翻译 科学研究所（CTSI）。受训人员将包括i）3名传统的博士生， 研究，ii）我们的DMD-博士课程的4名双学位候选人，iii）2名博士后科学家（T90;博士， DMD/DDS-PhD，DMD/DDS），以及iv）1名非公民，非永久居民DMD-PhD持有者寻求 高级博士后培训（R90），为他们在学术牙科的职业生涯做好准备。在大多数情况下，PhD 博士后学员将获得为期三年或两年的初步承诺， 而双学位学生则会在受训期间获得资助。额外的正式 将提供临床研究、实施科学或生物医学信息学方面的培训， 方案支持的个人。利用我们广泛的教育，科学， 临床资源使我们能够开发高度集成但足够灵活的培训选项，以满足 一个非常多样化的学员群体的需求。总的来说，这些方案将产生高技能和 互动科学家，他们可以参与团队科学，以产生新知识并将发现转化为 在口腔疾病和异常的检测、预防、治疗和治愈方面取得的切实进展 和颅面复合体 项目摘要/摘要第6页 联系PD/PI：Lemos，Jose A 叙事 迫切需要一批训练有素的基础和临床口腔健康研究人员。如果 有效的预防治疗和治疗与口腔，牙齿和颅面相关的许多疾病 复杂的是要发现和应用，口腔健康研究人员的骨干必须接受培训， 跨学科团队，并保持道德和负责任的严格行为的最高标准 科研这个综合培训计划的主要目标是生产口腔健康 研究人员可以应用最先进的技术来产生新的知识， 应用疗法，并严格评估实施新的预防或治疗的结果 改善人类健康的战略。

Contact PD/PI: Lemos, Jose A ABSTRACT In response to PAR-20-056 from the NIDCR to develop and enhance the Dental, Oral and Craniofacial Research Workforce, a T90/R90 Comprehensive Training Program in Oral Biology is proposed. The proposal builds on 29 years of experience with highly productive T32 and T90/R90 Training Programs at the University of Florida College of Dentistry (UFCD) and will provide extensive breadth and depth in training to basic and clinician scientists in multiple areas that are designated as high priority by the NIDCR. The scientific areas encompassed in this Comprehensive Training Program in Oral Biology include, but are not limited to, the Human Microbiome, Oral Infectious Diseases, Mechanistic Connections between Oral and Systemic Health, Virology, Salivary Gland Biology, Autoimmunity, Bone Biology, Head and Neck Cancers, Computational Biology, Biomedical Engineering, and Stem Cell Biology. To accomplish our goals, a team of accomplished basic and clinical researchers has been assembled to provide an extensive set of training experiences in the biomedical sciences that are directly relevant to oral health and diseases. Well-established interdisciplinary research training programs in the UFCD and the UF College of Medicine will be utilized, with particular emphasis on the Interdisciplinary PhD Program in Biomedical Sciences and the UF Clinical and Translational Science Institute (CTSI). Trainees will include i) 3 traditional PhD students conducting oral health-related research, ii) 4 dual-degree candidates in our DMD-PhD program, iii) 2 post-doctoral scientists (T90; PhD, DMD/DDS-PhD, DMD/DDS), and iv) 1 non-citizen, non-permanent resident DMD-PhD holders seeking advanced post-doctoral training (R90) to prepare them for careers in academic dentistry. In most cases, PhD and postdoctoral trainees will receive an initial commitment for appointments of three or two years, respectively, whereas dual-degree students will be supported for the duration of their training. Additional formal training in Clinical Investigation, Implementation Science or Biomedical Informatics will be available to individuals supported by the program. The use of combinations of our extensive educational, scientific, and clinical resources has allowed us to develop highly integrated yet sufficiently flexible training options to meet the needs of a very diverse group of trainees. Collectively, these programs will produce highly skilled and interactive scientists who can engage in team science to generate new knowledge and translate discoveries to tangible advances in the detection, prevention, treatment and cures of diseases and abnormalities of the oral and craniofacial complex. Project Summary/Abstract Page 6 Contact PD/PI: Lemos, Jose A NARRATIVE There is a critical need for a diverse group of highly trained basic and clinical oral health researchers. If effective preventive therapies and cures for the many diseases associated with the oral, dental and craniofacial complex are to be discovered and applied, a cadre of oral health researchers must be trained to work in interdisciplinary teams and to maintain the highest standards for ethical and responsible conduct of rigorous scientific research. The main objective of this comprehensive training program is to produce oral health researchers who can apply state-of-the-art technologies to generate new knowledge, translate that information to applied therapies, and rigorously evaluate the outcomes of implementation of novel preventive or treatment strategies to improve human health.