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Comprehensive Training Program in Oral Biology

口腔生物学综合培训计划

基本信息

批准号：
10652523
负责人：
Jose A Lemos
金额：
$ 49.69万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10652523
关键词：
Appointment Area Autoimmunity Biology Biomedical Engineering Clinical Clinical Sciences Communicable Diseases Computational Biology Dental Dentistry Detection Disease Doctor of Philosophy Education Florida Goals Head and Neck Cancer Health Human Microbiome Individual Interdisciplinary Study Knowledge Medicine Mouth Diseases National Institute of Dental and Craniofacial Research Oral Oral health Postdoctoral Fellow Prevention Productivity Research Research Personnel Resources Salivary Glands Science Scientist Students Training Training Programs Translating Translational Research Universities biomedical informatics bone career clinical investigation college craniofacial craniofacial complex doctoral student experience flexibility implementation science oral biology oral infection post-doctoral training programs response skills stem cell biology virology

项目摘要

In response to PAR-20-056 from the NIDCR to develop and enhance the Dental, Oral and Craniofacial Research Workforce, a T90/R90 Comprehensive Training Program in Oral Biology is proposed. The proposal builds on 29 years of experience with highly productive T32 and T90/R90 Training Programs at the University of Florida College of Dentistry (UFCD) and will provide extensive breadth and depth in training to basic and clinician scientists in multiple areas that are designated as high priority by the NIDCR. The scientific areas encompassed in this Comprehensive Training Program in Oral Biology include, but are not limited to, the Human Microbiome, Oral Infectious Diseases, Mechanistic Connections between Oral and Systemic Health, Virology, Salivary Gland Biology, Autoimmunity, Bone Biology, Head and Neck Cancers, Computational Biology, Biomedical Engineering, and Stem Cell Biology. To accomplish our goals, a team of accomplished basic and clinical researchers has been assembled to provide an extensive set of training experiences in the biomedical sciences that are directly relevant to oral health and diseases. Well-established interdisciplinary research training programs in the UFCD and the UF College of Medicine will be utilized, with particular emphasis on the Interdisciplinary PhD Program in Biomedical Sciences and the UF Clinical and Translational Science Institute (CTSI). Trainees will include i) 3 traditional PhD students conducting oral health-related research, ii) 4 dual-degree candidates in our DMD-PhD program, iii) 2 post-doctoral scientists (T90; PhD, DMD/DDS-PhD, DMD/DDS), and iv) 1 non-citizen, non-permanent resident DMD-PhD holders seeking advanced post-doctoral training (R90) to prepare them for careers in academic dentistry. In most cases, PhD and postdoctoral trainees will receive an initial commitment for appointments of three or two years, respectively, whereas dual-degree students will be supported for the duration of their training. Additional formal training in Clinical Investigation, Implementation Science or Biomedical Informatics will be available to individuals supported by the program. The use of combinations of our extensive educational, scientific, and clinical resources has allowed us to develop highly integrated yet sufficiently flexible training options to meet the needs of a very diverse group of trainees. Collectively, these programs will produce highly skilled and interactive scientists who can engage in team science to generate new knowledge and translate discoveries to tangible advances in the detection, prevention, treatment and cures of diseases and abnormalities of the oral and craniofacial complex.

为了响应NIDCR的PAR-20-056，开发和增强牙科、口腔和颅面研究人员，T90/R90口腔生物学综合培训计划的建议。该提案建立在29年的经验，在大学的高效T32和T90/R90培训计划佛罗里达牙科学院（UFCD），并将提供广泛的广度和深度的培训，以基本和 NIDCR指定为高优先级的多个领域的临床科学家。科学领域在口腔生物学综合培训计划包括，但不限于，人类微生物组，口腔传染病，口腔和全身健康之间的机械联系，病毒学，唾液腺生物学，自身免疫，骨生物学，头颈癌，计算生物学、生物医学工程和干细胞生物学。为了实现我们的目标，一个有成就的团队基础和临床研究人员已经聚集在一起，提供一套广泛的培训经验，与口腔健康和疾病直接相关的生物医学科学。成熟的跨学科将利用UFCD和UF医学院的研究培训计划，特别是强调跨学科博士课程在生物医学科学和UF临床和翻译科学研究所（CTSI）。受训人员将包括i）3名传统的博士生，研究，ii）我们的DMD-博士课程的4名双学位候选人，iii）2名博士后科学家（T90;博士， DMD/DDS-PhD，DMD/DDS），以及iv）1名非公民，非永久居民DMD-PhD持有者寻求高级博士后培训（R90），为他们在学术牙科的职业生涯做好准备。在大多数情况下，PhD 博士后学员将获得为期三年或两年的初步承诺，而双学位学生则会在受训期间获得资助。额外的正式将提供临床研究、实施科学或生物医学信息学方面的培训，方案支持的个人。利用我们广泛的教育，科学，临床资源使我们能够开发高度集成但足够灵活的培训选项，以满足一个非常多样化的学员群体的需求。总的来说，这些方案将产生高技能和互动科学家，他们可以参与团队科学，以产生新知识并将发现转化为在口腔疾病和异常的检测、预防、治疗和治愈方面取得的切实进展和颅面复合体

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Antiviral Activities of Human Host Defense Peptides.

DOI：
10.2174/0929867326666190805151654
发表时间：
2020
期刊：
CURRENT MEDICINAL CHEMISTRY
影响因子：
4.1
作者：
Brice, David C.;Diamond, Gill
通讯作者：
Diamond, Gill

Intestinal Epithelial Cell Regulation of Adaptive Immune Dysfunction in Human Type 1 Diabetes.

人类1型糖尿病中适应性免疫功能障碍的肠上皮细胞调节。

DOI：
10.3389/fimmu.2016.00679
发表时间：
2016
期刊：
Frontiers in immunology
影响因子：
7.3
作者：
Graves CL;Li J;LaPato M;Shapiro MR;Glover SC;Wallet MA;Wallet SM
通讯作者：
Wallet SM

CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma.

DOI：
10.1016/j.oraloncology.2018.01.024
发表时间：
2018-03
期刊：
Oral oncology
影响因子：
4.8
作者：
Park YP;Jin L;Bennett KB;Wang D;Fredenburg KM;Tseng JE;Chang LJ;Huang J;Chan EKL
通讯作者：
Chan EKL

Dangerous Liaisons: Caspase-11 and Reactive Oxygen Species Crosstalk in Pathogen Elimination.