Development of Cognitive and Physical Activity Biomarkers for a Companion Dog Model of Alzheimer's Disease
Development of Cognitive and Physical Activity Biomarkers for a Companion Dog Model of Alzheimer's Disease
批准号:
10118482
负责人:
Daniel Edward Promislow
金额:
$41.46万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-01 至 2023-06-30
关键词:
AccelerometerAddressAge-associated memory impairmentAgingAlgorithmsAlzheimer like pathologyAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAlzheimer&aposs disease riskAlzheimer&aposs disease therapeuticAnimal HospitalsAnimalsBiologicalBiological AssayBiological MarkersBiological ModelsCanis familiarisClinical TrialsCognitionCognitiveCognitive agingCohort StudiesCompanionsDay CareDementiaDevelopmentDiagnosticDiseaseEndogenous FactorsEnvironmentEquipmentExogenous FactorsFractalsFundingFutureGeneticHealth care facilityHealthcare SystemsHome environmentHumanImpaired cognitionImpairmentInterventionLaboratoriesLaboratory StudyLearningLinkLongitudinal StudiesMeasuresMemoryMethodsModelingNeuropsychological TestsNeuropsychologyOrganismOutcomeOutcome MeasurePatternPhysical activityPlayPopulationPositioning AttributePrivatizationProblem SolvingProceduresProcessPropertyProtocols documentationPublic HealthPublicationsResearchResearch DesignResearch PersonnelRiskRoleSamplingScientistSenile PlaquesSeverity of illnessSirolimusSystemTestingTimeTrainingTransgenic MiceUnited States National Institutes of Healthage effectage relatedbaseburden of illnesscitizen sciencecognitive developmentcognitive testingcomputerizeddesigndisorder riskexecutive functionflexibilityin vivoinnovationlife historyneuropathologyneuropsychiatrynovelpre-clinicalpreventtooltranslation to humansweb app
中文摘要
尽管经过数十年的研究,目前还没有任何治疗或干预措施可以预防或逆转这种疾病
英文摘要
Despite decades of research, there are currently no treatments or interventions that can prevent or reverse the
course of Alzheimer's disease. Model systems approaches provide a powerful opportunity for preclinical in vivo
studies in organisms with relatively fast life histories. However, current models rely largely on laboratory
populations of transgenic mice, with notable limitations for translation to humans. Recently, companion dogs
have been recognized as a valuable model in aging research because they share many important features with
humans, including the same living environments, disease risks and burdens, patterns of actuarial aging, and
access to a sophisticated health care system. Dogs also spontaneously develop age-related cognitive
impairments along with neuropathology resembling that seen in Alzheimer's disease, making them a potentially
powerful model system for Alzheimer's disease research. Although laboratory studies have made progress using
dogs as a model for Alzheimer's disease, current methods for assessing cognitive impairments in aging dogs
rely on specialized equipment and labor-intensive protocols that are not easily employed outside laboratory
settings, limiting our ability to capitalize on the unique benefits of a companion dog model. Thus, there is an
urgent need for validated measures and biomarkers focused on cognitive and physical impairments associated
with Alzheimer's disease which can be implemented in diverse study designs with companion dogs.
We will develop a set of neuropsychiatric tests and physical activity biomarkers that can be used as early
indicators, diagnostic tools, and outcome measures in a companion dog model of Alzheimer's disease.
Specifically, we will 1) adapt current laboratory neuropsychological tests for economical and scalable
implementation with companion dogs, 2) develop short-form cognitive assessments which can be completed by
citizen scientists, and 3) develop physical activity biomarkers in dogs, based on measures that predict
Alzheimer's disease risk and severity in humans. By integrating these measures with the Dog Aging Project – a
nationwide study of aging in 10,000+ companion dogs – we will lay the groundwork for future large-scale
research developing a companion dog model of Alzheimer's disease. The measures developed in this proposal
will provide key Alzheimer's disease-related endpoints for existing studies in the Dog Aging Project, such as the
Test of Rapamycin in Aging Dogs – which implements a veterinary clinical trial of Rapamycin – a promising
therapeutic for Alzheimer's disease. Following the development of these measures, researchers will be well
positioned to investigate diverse hypotheses about endogenous and exogenous factors contributing to cognitive
impairments and dementia, in a model with strong potential for translation to humans.
期刊论文(0)
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科研奖励(0)
会议论文
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批准号:10625366
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资助金额:$5.81万
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批准号:10450314
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批准号:10674251
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依托单位:
Biological Mechanisms of Healthy Aging Training Grant
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批准号:10627867
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资助金额:$79.49万
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依托单位:
Biological Mechanisms of Healthy Aging Training Grant
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批准号:10407664
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项目类别:
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资助金额:$77.6万
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财政年份:2020
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负责人:Daniel Edward Promislow
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依托单位:
Core A: Administrative Core
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批准号:10440334
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项目类别:
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资助金额:$39.03万
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财政年份:2018
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负责人:Daniel Edward Promislow
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依托单位:
Development and Use of an AI/ML-Ready Dog Aging Project Dataset
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批准号:10409023
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项目类别:
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资助金额:$31.06万
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财政年份:2018
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负责人:Daniel Edward Promislow
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依托单位:
Project 3: Systems Biology Multi-Omic Studies Of Healthy Aging In Companion Dogs
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批准号:10440340
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项目类别:
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资助金额:$87.8万
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财政年份:2018
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负责人:Daniel Edward Promislow
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依托单位:
Enhancing the power of genomic analysis in the Dog Aging Project
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批准号:10224459
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项目类别:
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资助金额:$16.75万
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财政年份:2018
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负责人:Daniel Edward Promislow
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依托单位:
The Dog Aging Project: Genetic and Environmental Determinants of Healthy Aging in Companion Dogs
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批准号:10370217
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项目类别:
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资助金额:$8.3万
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财政年份:2018
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负责人:Daniel Edward Promislow
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依托单位:
Core A: Administrative Core
-
批准号:10213624
-
项目类别:
-
资助金额:$56.89万
-
财政年份:2018
-
负责人:Daniel Edward Promislow
-
依托单位:
Core C
-
批准号:10440342
-
项目类别:
-
资助金额:$62.31万
-
财政年份:2018
-
负责人:Daniel Edward Promislow
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依托单位:
Core A: Administrative Core
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批准号:10876620
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项目类别:
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资助金额:$220.42万
-
财政年份:2018
-
负责人:Daniel Edward Promislow
-
依托单位:
Project 3: Systems Biology Multi-Omic Studies Of Healthy Aging In Companion Dogs
-
批准号:10213630
-
项目类别:
-
资助金额:$56.89万
-
财政年份:2018
-
负责人:Daniel Edward Promislow
-
依托单位:
The Dog Aging Project: Genetic and Environmental Determinants of Healthy Aging in Companion Dogs
-
批准号:10213623
-
项目类别:
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资助金额:$455.1万
-
财政年份:2018
-
负责人:Daniel Edward Promislow
-
依托单位:
The Dog Aging Project: Genetic and Environmental Determinants of Healthy Aging in Companion Dogs
-
批准号:9981564
-
项目类别:
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资助金额:$518.04万
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财政年份:2018
-
负责人:Daniel Edward Promislow
-
依托单位:
The Dog Aging Project: Genetic and Environmental Determinants of Healthy Aging in Companion Dogs
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批准号:10437998
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项目类别:
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资助金额:$61.89万
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财政年份:2018
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负责人:Daniel Edward Promislow
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依托单位:
A systems biology approach in Drosophila to identify novel factors that influence AD pathogenicity
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批准号:9413012
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资助金额:$335.5万
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财政年份:2017
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负责人:Daniel Edward Promislow
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依托单位:
Multi-group covariance estimation for metabolomic analysis with applications to neurodegenerative disease
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批准号:9218404
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项目类别:
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资助金额:$14.51万
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财政年份:2016
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负责人:Daniel Edward Promislow
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依托单位:
Metabolome-Genome Associations for Determining Mechanisms of Aging in Drosophila
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批准号:9268534
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财政年份:2015
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依托单位:
海外基金