Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)
转化结果项目:可视化神经创伤的症状信息和结果 (TOP-VISION)
基本信息
- 批准号:10408138
- 负责人:
- 金额:$ 32.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-04-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAnatomyAnimal ModelAreaBehavioralBig DataBig Data MethodsBiologicalBiological MarkersBrainBrain InjuriesClinicalCollaborationsComplexDataData CollectionData CommonsData ElementData PoolingData ScienceData SourcesDetectionDrug TargetingFAIR principlesFunctional disorderFundingGenerationsGoalsHealthcareHeterogeneityHousingHumanIndividualInjuryKnowledgeMachine LearningMedicalModelingModernizationMolecularMultiple TraumaMusNervous System TraumaNeuraxisOutcomeOutcome AssessmentPatternPersonsPhasePhysiologicalPositioning AttributePrecision HealthPrevalenceProcessRattusRecoveryRecovery of FunctionReproducibilityResearch PersonnelRodentSensitivity and SpecificitySeveritiesSiteSpinal CordSpinal InjuriesSpinal cord injurySyndromeSystemTestingTherapeuticTimeTranslationsTraumaTraumatic Brain InjuryTraumatic CNS injuryTreatment EfficacyU-Series Cooperative AgreementsUnited States National Institutes of HealthValidationWeightWorkbench-to-bedside translationbiobehaviorbiomarker discoverybody systemclinically relevantcostdata curationdata integrationdata repositorydata resourcediverse dataeconomic costeconomic impactexperimental studyfunctional outcomesheterogenous datainnovationinsightlarge scale dataneuroinflammationnovelpre-clinicalprecision medicinepreclinical studypredictive modelingproductivity lossrepositoryresponse to injuryspinal cord and brain injurysuccesstherapeutic developmenttherapeutic evaluationtooltranslational therapeutics
项目摘要
PROJECT SUMMARY: Trauma to the spinal cord and brain (neurotrauma) together impact over 2.5 million
people per year in the US, with economic costs of $80 billion in healthcare and loss-of-productivity. Yet precise
pathophysiological processes impacting recovery remain poorly understood. This lack of knowledge limits the
reliability of therapeutic development in animal models and limits translation across species and into humans.
Part of the problem is that neurotrauma is intrinsically complex, involving heterogeneous damage to the central
nervous system (CNS), the most complex organ system in the body. This results in a multifarious CNS
syndrome spanning across heterogeneous data sources and multiple scales of analysis. Multi-scale
heterogeneity makes spinal cord injury (SCI) and traumatic brain injury (TBI) difficult to understand using
traditional analytical approaches that focus on a single endpoint for testing therapeutic efficacy. Single
endpoint-testing provides a narrow window into the complex system of changes that describe the holistic
syndromes of SCI and TBI. In this sense, complex neurotrauma is fundamentally a problem that requires big-
data analytics to evaluate reproducibility in basic discovery and cross-species translation. For the proposed
TOP-VISION cooperative agreement we will: 1) integrate preclinical neurotrauma data on a large-scale; 2)
develop novel applications of cutting-edge multidimensional analytics to make sense of complex neurotrauma
data; and 3) validate bio-functional patterns in targeted big-data-to-bench experiments in multi-PI single center
(UG3 phase), and multicenter (UH3 phase) studies. The goal of the proposed project is to develop an
integrated workflow for preclinical discovery, reproducibility testing, and translational discovery both within and
across neurotrauma types. Our team is well-positioned to execute this project given that with prior NIH funding
we built one of the largest multicenter, multispecies repositories of neurotrauma data to-date, housing detailed
multidimensional outcome data on nearly N=5000 preclinical subjects and over 20,000 curated variables. We
will leverage these existing data resources and apply recent innovations from data science to render complex
multidimensional endpoint data into robust syndromic patterns that can be visualized and explored by
researchers and clinicians for discovery, hypothesis-generation and ultimately translational outcome testing.
项目摘要:脊髓和大脑创伤(神经创伤)共同影响了超过 250 万人
美国每年因医疗保健和生产力损失而造成的经济损失高达 800 亿美元。但又精确
影响恢复的病理生理过程仍然知之甚少。这种知识的缺乏限制了
动物模型中治疗开发的可靠性并限制了跨物种和人类的转化。
部分问题在于神经创伤本质上很复杂,涉及中枢神经系统的异质性损伤。
神经系统(CNS),体内最复杂的器官系统。这导致了多种多样的中枢神经系统
跨越异构数据源和多种分析尺度的综合症。多尺度
异质性使得脊髓损伤(SCI)和创伤性脑损伤(TBI)难以使用理解
传统的分析方法侧重于测试治疗效果的单一终点。单身的
端点测试为了解描述整体的复杂变化系统提供了一个狭窄的窗口
SCI 和 TBI 综合征。从这个意义上说,复杂的神经创伤从根本上来说是一个需要大量研究的问题。
数据分析来评估基本发现和跨物种翻译的可重复性。对于提议的
TOP-VISION合作协议我们将:1)大规模整合临床前神经创伤数据; 2)
开发尖端多维分析的新颖应用,以理解复杂的神经创伤
数据; 3) 在多 PI 单中心的针对性大数据平台实验中验证生物功能模式
(UG3 期)和多中心(UH3 期)研究。拟议项目的目标是开发一个
用于临床前发现、重现性测试和转化发现的集成工作流程
跨神经创伤类型。鉴于先前有 NIH 资助,我们的团队有能力执行该项目
我们建立了迄今为止最大的多中心、多物种神经创伤数据存储库之一,内容详细
近 N=5000 名临床前受试者和超过 20,000 个策划变量的多维结果数据。我们
将利用这些现有的数据资源并应用数据科学的最新创新来呈现复杂的
将多维端点数据转化为强大的综合症模式,可以通过以下方式进行可视化和探索
研究人员和临床医生进行发现、假设生成和最终的转化结果测试。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Safety and comparative efficacy of initiating low-molecular-weight heparin within 24 hours of injury or surgery for venous thromboembolism prophylaxis in patients with spinal cord injury: a prospective TRACK-SCI registry study.
脊髓损伤患者受伤或手术后 24 小时内开始使用低分子量肝素预防静脉血栓栓塞的安全性和比较疗效:一项前瞻性 TRACK-SCI 注册研究。
- DOI:10.3171/2023.7.focus23362
- 发表时间:2023
- 期刊:
- 影响因子:4.1
- 作者:Lui,Austin;Park,Christine;Chryssikos,Timothy;Radabaugh,Hannah;Patel,Arati;Aabedi,AlexanderA;Ferguson,AdamR;TorresEspin,Abel;Mummaneni,PraveenV;Dhall,SanjayS;Duong-Fernandez,Xuan;Saigal,Rajiv;Chou,Austin;Pan,Jonathan;Singh,
- 通讯作者:Singh,
Phenotyping the Spectrum of Traumatic Brain Injury: A Review and Pathway to Standardization.
- DOI:10.1089/neu.2021.0059
- 发表时间:2021-12
- 期刊:
- 影响因子:4.2
- 作者:Pugh MJ;Kennedy E;Prager EM;Humpherys J;Dams-O'Connor K;Hack D;McCafferty MK;Wolfe J;Yaffe K;McCrea M;Ferguson AR;Lancashire L;Ghajar J;Lumba-Brown A
- 通讯作者:Lumba-Brown A
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JACQUELINE C BRESNAHAN其他文献
JACQUELINE C BRESNAHAN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JACQUELINE C BRESNAHAN', 18)}}的其他基金
Embryonic Stem Cell Therapy after Cervical Contusion SCI in NHPs
NHP 宫颈挫伤 SCI 后的胚胎干细胞治疗
- 批准号:
10568090 - 财政年份:2023
- 资助金额:
$ 32.3万 - 项目类别:
Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)
转化结果项目:可视化神经创伤的症状信息和结果 (TOP-VISION)
- 批准号:
10092617 - 财政年份:2018
- 资助金额:
$ 32.3万 - 项目类别:
Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)
转化结果项目:可视化神经创伤的症状信息和结果 (TOP-VISION)
- 批准号:
10199067 - 财政年份:2018
- 资助金额:
$ 32.3万 - 项目类别:
Embryonic stem cell therapy after cervical contusion SCI in NHPs
NHP 宫颈挫伤 SCI 后的胚胎干细胞治疗
- 批准号:
9472452 - 财政年份:2017
- 资助金额:
$ 32.3万 - 项目类别:
Embryonic stem cell therapy after cervical contusion SCI in NHPs
NHP 宫颈挫伤 SCI 后的胚胎干细胞治疗
- 批准号:
10210306 - 财政年份:2017
- 资助金额:
$ 32.3万 - 项目类别:
Plasticity and Regeneration in the Primate Spinal Cord
灵长类脊髓的可塑性和再生
- 批准号:
8438429 - 财政年份:2011
- 资助金额:
$ 32.3万 - 项目类别:
Plasticity and Regeneration in the Primate Spinal Cord
灵长类脊髓的可塑性和再生
- 批准号:
8318074 - 财政年份:2011
- 资助金额:
$ 32.3万 - 项目类别:
Plasticity and Regeneration in the Primate Spinal Cord
灵长类脊髓的可塑性和再生
- 批准号:
8640211 - 财政年份:2011
- 资助金额:
$ 32.3万 - 项目类别:
相似海外基金
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 32.3万 - 项目类别:
Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 32.3万 - 项目类别:
Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 32.3万 - 项目类别:
Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 32.3万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 32.3万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 32.3万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 32.3万 - 项目类别:
Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
- 批准号:
2301846 - 财政年份:2023
- 资助金额:
$ 32.3万 - 项目类别:
Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 32.3万 - 项目类别:
Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
- 批准号:
23K16076 - 财政年份:2023
- 资助金额:
$ 32.3万 - 项目类别:
Grant-in-Aid for Early-Career Scientists