Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)

转化结果项目:可视化神经创伤的症状信息和结果 (TOP-VISION)

基本信息

项目摘要

PROJECT SUMMARY: Trauma to the spinal cord and brain (neurotrauma) together impact over 2.5 million people per year in the US, with economic costs of $80 billion in healthcare and loss-of-productivity. Yet precise pathophysiological processes impacting recovery remain poorly understood. This lack of knowledge limits the reliability of therapeutic development in animal models and limits translation across species and into humans. Part of the problem is that neurotrauma is intrinsically complex, involving heterogeneous damage to the central nervous system (CNS), the most complex organ system in the body. This results in a multifarious CNS syndrome spanning across heterogeneous data sources and multiple scales of analysis. Multi-scale heterogeneity makes spinal cord injury (SCI) and traumatic brain injury (TBI) difficult to understand using traditional analytical approaches that focus on a single endpoint for testing therapeutic efficacy. Single endpoint-testing provides a narrow window into the complex system of changes that describe the holistic syndromes of SCI and TBI. In this sense, complex neurotrauma is fundamentally a problem that requires big- data analytics to evaluate reproducibility in basic discovery and cross-species translation. For the proposed TOP-VISION cooperative agreement we will: 1) integrate preclinical neurotrauma data on a large-scale; 2) develop novel applications of cutting-edge multidimensional analytics to make sense of complex neurotrauma data; and 3) validate bio-functional patterns in targeted big-data-to-bench experiments in multi-PI single center (UG3 phase), and multicenter (UH3 phase) studies. The goal of the proposed project is to develop an integrated workflow for preclinical discovery, reproducibility testing, and translational discovery both within and across neurotrauma types. Our team is well-positioned to execute this project given that with prior NIH funding we built one of the largest multicenter, multispecies repositories of neurotrauma data to-date, housing detailed multidimensional outcome data on nearly N=5000 preclinical subjects and over 20,000 curated variables. We will leverage these existing data resources and apply recent innovations from data science to render complex multidimensional endpoint data into robust syndromic patterns that can be visualized and explored by researchers and clinicians for discovery, hypothesis-generation and ultimately translational outcome testing.
项目总结:脊髓和大脑的创伤(神经创伤)总共影响了250多万人

项目成果

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JACQUELINE C BRESNAHAN其他文献

JACQUELINE C BRESNAHAN的其他文献

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{{ truncateString('JACQUELINE C BRESNAHAN', 18)}}的其他基金

Embryonic Stem Cell Therapy after Cervical Contusion SCI in NHPs
NHP 宫颈挫伤 SCI 后的胚胎干细胞治疗
  • 批准号:
    10568090
  • 财政年份:
    2023
  • 资助金额:
    $ 32.3万
  • 项目类别:
Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)
转化结果项目:可视化神经创伤的症状信息和结果 (TOP-VISION)
  • 批准号:
    10408138
  • 财政年份:
    2018
  • 资助金额:
    $ 32.3万
  • 项目类别:
FAIR VISION for TOP-NT
TOP-NT 的公平愿景
  • 批准号:
    10407811
  • 财政年份:
    2018
  • 资助金额:
    $ 32.3万
  • 项目类别:
Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)
转化结果项目:可视化神经创伤的症状信息和结果 (TOP-VISION)
  • 批准号:
    10199067
  • 财政年份:
    2018
  • 资助金额:
    $ 32.3万
  • 项目类别:
Embryonic stem cell therapy after cervical contusion SCI in NHPs
NHP 宫颈挫伤 SCI 后的胚胎干细胞治疗
  • 批准号:
    9472452
  • 财政年份:
    2017
  • 资助金额:
    $ 32.3万
  • 项目类别:
Embryonic stem cell therapy after cervical contusion SCI in NHPs
NHP 宫颈挫伤 SCI 后的胚胎干细胞治疗
  • 批准号:
    10210306
  • 财政年份:
    2017
  • 资助金额:
    $ 32.3万
  • 项目类别:
32nd Annual National Neurotrauma Symposium
第32届全国神经创伤年度研讨会
  • 批准号:
    8785233
  • 财政年份:
    2014
  • 资助金额:
    $ 32.3万
  • 项目类别:
Plasticity and Regeneration in the Primate Spinal Cord
灵长类脊髓的可塑性和再生
  • 批准号:
    8438429
  • 财政年份:
    2011
  • 资助金额:
    $ 32.3万
  • 项目类别:
Plasticity and Regeneration in the Primate Spinal Cord
灵长类脊髓的可塑性和再生
  • 批准号:
    8318074
  • 财政年份:
    2011
  • 资助金额:
    $ 32.3万
  • 项目类别:
Plasticity and Regeneration in the Primate Spinal Cord
灵长类脊髓的可塑性和再生
  • 批准号:
    8640211
  • 财政年份:
    2011
  • 资助金额:
    $ 32.3万
  • 项目类别:

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