Training in the Neurobiology of Aging and Alzheimer's Disease

总结 随着“美国的老龄化”，我们面临着解决不断增加的数字的需要。 在我们的社会中，有与年龄相关的神经系统疾病和病症的个体。 为了解决这个问题，我们需要多学科的方法来促进发现 机制、治疗和预防这些疾病。积极的、综合的研究 培养博士预科生是补充研究人员的关键， 以可持续的方式解决这些生物医学保健问题。在此，我们建议 继续在北德克萨斯州健康科学大学成功的博士预科课程 中心（UNTHSC），专注于衰老的神经生物学。在这个融资周期中，我们 支持了33名研究员，其中22人完成了培训并获得了博士学位。练习生们 非常富有成效，迄今为止发表了46篇同行评审论文;我们还培训了7篇（33篇中的7篇）。 21.2%）少数民族学生。重要的是，我们提高了我们的保留/毕业率从84.6%， 在最近的供资周期中，将前5年供资期的供资率提高到100%。拟议的培训 该计划将加强已经强大和成功的神经生物学培训计划， 衰老我们的博士前培训计划的继续提出，作为我们的研究所， 健康老龄化已经成熟，通过增加教师和继续资助计划 项目赠款，如PI Meharvan Singh博士领导的项目。这种增长促进了更多 对脑卒中的病因、治疗和预防进行基础、转化和临床研究 老龄化和老年痴呆症。总的来说，这些新举措创造了一个 在老化的神经生物学的博士前学生的培训刺激的环境。 下一个资助期培训计划的独特和创新特点包括：（1） 几个体验式学习机会，包括老年医学技能实验室和 翻译老化和阿尔茨海默病研究计划;（2）我们继续强调 多元化培训，使少数族裔参与培训方案的比例超过20%; 3)职业咨询和面试技能发展计划，4）神经科学技术 计划; 5）我们的机构支持，这将扩大那些学生谁将有机会获得 部分或全部培训计划; 6）我们专注于研究卓越的发展， 我们的学员中的领导力;以及7）我们的导师计划， 在资深教员的指导下指导学员。总的来说，这些属性 我们的衰老神经生物学培训计划已经产生了一个优秀的培训计划 我们希望继续。

Summary With the “graying of America” we are faced with the need to address the ever increasing number of individuals in our society who have age-associated nervous system diseases and conditions. To address this problem, we need multidisciplinary approaches to facilitate the discovery of the mechanisms, treatments and prevention of these diseases. Active, integrated research-based training of pre-doctoral students is a key to re-supplying the research personnel needed to address these biomedical health care issues in a sustainable manner. Herein we propose to continue a successful pre-doctoral program at the University of North Texas Health Science Center (UNTHSC) that focuses on the neurobiology of aging. During this funding cycle we supported 33 fellows, of whom 22 completed their training and their Ph.D. The trainees were very productive and published 46 peer-reviewed papers to date; we also trained 7 (of 33 = 21.2%) minority students. Importantly, we increased our retention/graduation rate from 84.6% in the prior 5-year funding period to 100% in the most recent funding cycle. The proposed training program will enhance an already strong and successful training program in the neurobiology of aging. The continuation of our predoctoral training program is proposed, as our Institute for Healthy Aging has matured through the addition of faculty and continued funding of program project grants, such as that led by the PI, Dr. Meharvan Singh. Such growth has facilitated more basic, translational and clinical research into the causes, treatment and prevention of brain aging and Alzheimer's Disease at the UNTHSC. Collectively, these new initiatives create a stimulating environment for the training of predoctoral students in the neurobiology of aging. Unique and innovative features of the training program for the next period of funding include: (1) Several experiential learning opportunities to include the Geriatrics Skills Lab and the Translational Aging & Alzheimer's Disease Research Program; (2) our continued emphasis on diversity training, that resulted in greater than 20% minority participation in the training program; 3) Career counseling and interview skill development program, 4) techniques in neuroscience program; 5) our institutional support which will expand those students who will have access to some or all of this training program; 6) our focus on the development of research excellence and leadership among our trainees; and 7) our Mentoring-the-Mentor Program which trains junior faculty in mentoring trainees under the guidance of a senior faculty. Collectively, these attributes of our Neurobiology of Aging Training Program has produced an outstanding program of training that we wish to continue.