Harmonist: A Scalable Toolkit for Standardizing and Coordinating Data Sharing Across International Research Networks

项目摘要 协调全球多队列合作数据所需的大量时间和精力可能导致 研究延迟，特别是考虑到数据、数据管理能力和数据共享的异质性 规定Harmonist项目的目标是开发数据标准、软件和方法， 艾滋病毒观察研究联合会协调多区域研究项目和应用数据 更有效和高效地管理最佳实践。为了提高可重用性，构建了Harmonist工具 (when作为广泛使用的研究电子数据采集的可共享外部模块 （REDCap）软件，截至2020年年中，该软件已在138个国家的4，450多家机构中使用。初始 Harmonist工具套件包括Harmonist Hub，一个用于科学项目和投资组合管理的平台， 以及数据工具包，这是一个基于网络的数据质量检查和安全数据交换系统。 协调员项目旨在（1）加强数据协调和财团对国际 评估艾滋病流行病学数据库（IeDEA）联盟，包括提供新的数据框架， IEDEA前瞻性研究，（2）扩大对区域前瞻性观察研究的支持， 结核病（报告）国际财团，研究结核病的背景下，艾滋病毒，和（3）支持双- 围绕Harmonist工具、数据管理最佳实践和数据进行定向指导和共享 标准 这项建议是范德比尔特大学医学中心研究信息学专家之间的合作， 7个区域网络，包括IEDEA和REPORT International。这些伙伴关系确保所有组成部分 Harmonist以实用的方式满足现实世界的用户需求，并为专门的用户提供工具 基地我们相信这些研究工具可以减少关键数据管理所需的时间和精力 和行政任务，这些任务是研究全球流行病的观察性艾滋病毒队列的作用的基础。的 我们设计的模块化基础设施可以适应不同的研究环境，并扩展到包括新的 数据类型和来源随着对艾滋病毒的理解的发展。由此产生的可共享软件和指导 这些资源将为IeDEA、RePORT和更广泛的艾滋病毒提供切实的直接和长期利益 研究社区。

PROJECT SUMMARY The substantial time and effort required to harmonize data for global multi-cohort collaborations can lead to research delays, particularly given heterogeneity in data, data management capacity, and data sharing regulations. The goal of the Harmonist project is to develop data standards, software, and methods that help HIV observational research consortia to coordinate multiregional research projects and apply data management best practices more effectively and efficiently. To promote reusability, Harmonist tools are built (when feasible) as shareable External Modules for the widely used Research Electronic Data Capture (REDCap) software, which is in use at over 4,450 institutions in 138 countries as of mid-2020. The initial Harmonist suite of tools includes the Harmonist Hub, a platform for scientific project and portfolio management, and the Data Toolkit, a web-based system for data quality checking and secure data exchange. The Harmonist project aims to (1) strengthen data harmonization and consortium support for the International epidemiologic Databases to Evaluate AIDS (IeDEA) consortium, including providing a new data framework for IeDEA prospective studies, (2) expand support to the Regional Prospective Observational Research for Tuberculosis (RePORT) International consortium, which studies TB in the context of HIV, and (3) support bi- directional mentorship and sharing around Harmonist tools, data management best practices, and data standards. This proposal is a collaboration among research informatics experts at Vanderbilt University Medical Center, all seven regional networks of IeDEA, and RePORT International. These partnerships ensure that all components of Harmonist address real-world user needs in a practical manner and provide the tools with a dedicated user base. We believe that these research tools can reduce the time and effort needed for critical data management and administrative tasks that underlie the role of observational HIV cohorts studying the global epidemic. The modular infrastructure we have designed can adapt to diverse research settings and expand to include new data types and sources as the understanding of HIV evolves. The resulting shareable software and mentoring resources will provide tangible immediate and long-term benefits to IeDEA, RePORT, and the broader HIV research community.