Harmonist: A Scalable Toolkit for Standardizing and Coordinating Data Sharing Across International Research Networks

项目概要 协调全球多队列协作数据所需的大量时间和精力可能会导致 研究延迟，特别是考虑到数据、数据管理能力和数据共享的异质性 法规。 Harmonist 项目的目标是开发数据标准、软件和方法，以帮助 艾滋病毒观察研究联盟协调多区域研究项目和应用数据 更有效和高效的管理最佳实践。为了促进可重用性，构建了 Harmonist 工具 （如果可行）作为广泛使用的研究电子数据采集的可共享外部模块 (REDCap) 软件，截至 2020 年中期，已在 138 个国家/地区的 4,450 多家机构使用。最初的 Harmonist 工具套件包括 Harmonist Hub，这是一个用于科学项目和投资组合管理的平台， 数据工具包是一个基于网络的数据质量检查和安全数据交换系统。 Harmonist 项目旨在 (1) 加强数据协调和联盟对国际组织的支持 评估艾滋病流行病学数据库 (IeDEA) 联盟，包括提供新的数据框架 IeDEA 前瞻性研究，(2) 扩大对区域前瞻性观察研究的支持 结核病 (RePORT) 国际联盟，在艾滋病毒背景下研究结核病，以及 (3) 支持双 围绕 Harmonist 工具、数据管理最佳实践和数据进行定向指导和共享 标准。 该提案是范德比尔特大学医学中心研究信息学专家之间的合作，所有 IeDEA 和 RePORT International 的七个区域网络。这些合作伙伴关系确保所有组件 Harmonist 以实用的方式满足现实世界的用户需求，并为专门的用户提供工具 基地。我们相信这些研究工具可以减少关键数据管理所需的时间和精力 以及管理任务，这些任务是研究全球流行病的观察性艾滋病队列的作用的基础。的 我们设计的模块化基础设施可以适应不同的研究环境并扩展到包括新的 随着对艾滋病毒理解的不断发展，数据类型和来源。由此产生的可共享软件和指导 资源将为 IeDEA、RePORT 和更广泛的艾滋病毒领域提供切实的近期和长期效益 研究社区。

PROJECT SUMMARY The substantial time and effort required to harmonize data for global multi-cohort collaborations can lead to research delays, particularly given heterogeneity in data, data management capacity, and data sharing regulations. The goal of the Harmonist project is to develop data standards, software, and methods that help HIV observational research consortia to coordinate multiregional research projects and apply data management best practices more effectively and efficiently. To promote reusability, Harmonist tools are built (when feasible) as shareable External Modules for the widely used Research Electronic Data Capture (REDCap) software, which is in use at over 4,450 institutions in 138 countries as of mid-2020. The initial Harmonist suite of tools includes the Harmonist Hub, a platform for scientific project and portfolio management, and the Data Toolkit, a web-based system for data quality checking and secure data exchange. The Harmonist project aims to (1) strengthen data harmonization and consortium support for the International epidemiologic Databases to Evaluate AIDS (IeDEA) consortium, including providing a new data framework for IeDEA prospective studies, (2) expand support to the Regional Prospective Observational Research for Tuberculosis (RePORT) International consortium, which studies TB in the context of HIV, and (3) support bi- directional mentorship and sharing around Harmonist tools, data management best practices, and data standards. This proposal is a collaboration among research informatics experts at Vanderbilt University Medical Center, all seven regional networks of IeDEA, and RePORT International. These partnerships ensure that all components of Harmonist address real-world user needs in a practical manner and provide the tools with a dedicated user base. We believe that these research tools can reduce the time and effort needed for critical data management and administrative tasks that underlie the role of observational HIV cohorts studying the global epidemic. The modular infrastructure we have designed can adapt to diverse research settings and expand to include new data types and sources as the understanding of HIV evolves. The resulting shareable software and mentoring resources will provide tangible immediate and long-term benefits to IeDEA, RePORT, and the broader HIV research community.