Harmonist: A Scalable Toolkit for Standardizing and Coordinating Data Sharing Across International Research Networks

Harmonist：用于标准化和协调国际研究网络数据共享的可扩展工具包

• 批准号: 10254965
• 负责人: Stephany Norah Duda
• 金额: $ 175.01万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-25 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10254965
• 关键词: Academic Medical Centers; Acquired Immunodeficiency Syndrome; Address; Area; Caring; Clinical Research; Cohort Studies; Collaborations; Communicable Diseases; Communities; Computer software; Country; Data; Data Collection; Data Set; Databases; Development; Ensure; Epidemic; Epidemiology; Evaluation Research; Evolution; Face; Feedback; Funding; Future; Goals; Grant; HIV; HIV/TB; Heterogeneity; Incidence; Informatics; Infrastructure; Institution; International; Lead; Measures; Medicine; Mentors; Mentorship; Methodology; Methods; Monitor; Monoclonal Antibody R24; National Institute of Allergy and Infectious Disease; Observation in research; Observational Study; Online Systems; Participant; Pattern; Persons; Productivity; Prospective Studies; Prospective cohort; Publications; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; Research Training; Resource Development; Resources; Role; Secure; Site; Source; Standardization; Strategic Planning; Structure; System; Testing; Time; Training; Tuberculosis; United States National Institutes of Health; Work; base; co-infection; cohort; comorbidity; data exchange; data framework; data harmonization; data management; data modeling; data pipeline; data quality; data sharing; data standards; design; distributed data; electronic data; epidemiology study; improved; innovation; open source; operation; programs; prospective; satisfaction; success; support tools; synergism; tool; treatment site; user-friendly; web-based tool

PROJECT SUMMARY The substantial time and effort required to harmonize data for global multi-cohort collaborations can lead to research delays, particularly given heterogeneity in data, data management capacity, and data sharing regulations. The goal of the Harmonist project is to develop data standards, software, and methods that help HIV observational research consortia to coordinate multiregional research projects and apply data management best practices more effectively and efficiently. To promote reusability, Harmonist tools are built (when feasible) as shareable External Modules for the widely used Research Electronic Data Capture (REDCap) software, which is in use at over 4,450 institutions in 138 countries as of mid-2020. The initial Harmonist suite of tools includes the Harmonist Hub, a platform for scientific project and portfolio management, and the Data Toolkit, a web-based system for data quality checking and secure data exchange. The Harmonist project aims to (1) strengthen data harmonization and consortium support for the International epidemiologic Databases to Evaluate AIDS (IeDEA) consortium, including providing a new data framework for IeDEA prospective studies, (2) expand support to the Regional Prospective Observational Research for Tuberculosis (RePORT) International consortium, which studies TB in the context of HIV, and (3) support bi- directional mentorship and sharing around Harmonist tools, data management best practices, and data standards. This proposal is a collaboration among research informatics experts at Vanderbilt University Medical Center, all seven regional networks of IeDEA, and RePORT International. These partnerships ensure that all components of Harmonist address real-world user needs in a practical manner and provide the tools with a dedicated user base. We believe that these research tools can reduce the time and effort needed for critical data management and administrative tasks that underlie the role of observational HIV cohorts studying the global epidemic. The modular infrastructure we have designed can adapt to diverse research settings and expand to include new data types and sources as the understanding of HIV evolves. The resulting shareable software and mentoring resources will provide tangible immediate and long-term benefits to IeDEA, RePORT, and the broader HIV research community.

项目总结