Harmonist: A Scalable Toolkit for Standardizing and Coordinating Data Sharing Across International Research Networks

Harmonist：用于标准化和协调国际研究网络数据共享的可扩展工具包

• 批准号: 10604380
• 负责人: Stephany Norah Duda
• 金额: $ 66.17万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-25 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10604380
• 关键词: Academic Medical Centers; Acceleration; Acquired Immunodeficiency Syndrome; Address; Area; Caring; Clinical Research; Cohort Studies; Collaborations; Communicable Diseases; Communities; Computer software; Country; Data; Data Collection; Data Set; Databases; Dedications; Development; Disease; Ensure; Epidemic; Epidemiology; Evaluation Research; Evolution; Face; Feedback; Funding; Future; Goals; Grant; HIV; HIV/TB; Heterogeneity; Incidence; Informatics; Infrastructure; Institution; International; Measures; Medicine; Mentors; Mentorship; Methodology; Methods; Monitor; National Institute of Allergy and Infectious Disease; Observation in research; Observational Study; Participant; Pattern; Persons; Productivity; Prospective Studies; Prospective cohort; Publications; R24; Regulation; Research; Research Personnel; Research Project Grants; Research Proposals; Research Training; Resource Development; Resources; Role; Secure; Site; Source; Standardization; Strategic Planning; Structure; Testing; Time; Training; Tuberculosis; United States National Institutes of Health; Work; base; co-infection; cohort; comorbidity; data exchange; data framework; data harmonization; data management; data modeling; data pipeline; data quality; data sharing; data standards; design; distributed data; electronic data; epidemiology study; improved; innovation; open source; operation; programs; prospective; satisfaction; success; support tools; synergism; tool; treatment site; user-friendly; web platform; web-based tool

PROJECT SUMMARY The substantial time and effort required to harmonize data for global multi-cohort collaborations can lead to research delays, particularly given heterogeneity in data, data management capacity, and data sharing regulations. The goal of the Harmonist project is to develop data standards, software, and methods that help HIV observational research consortia to coordinate multiregional research projects and apply data management best practices more effectively and efficiently. To promote reusability, Harmonist tools are built (when feasible) as shareable External Modules for the widely used Research Electronic Data Capture (REDCap) software, which is in use at over 4,450 institutions in 138 countries as of mid-2020. The initial Harmonist suite of tools includes the Harmonist Hub, a platform for scientific project and portfolio management, and the Data Toolkit, a web-based system for data quality checking and secure data exchange. The Harmonist project aims to (1) strengthen data harmonization and consortium support for the International epidemiologic Databases to Evaluate AIDS (IeDEA) consortium, including providing a new data framework for IeDEA prospective studies, (2) expand support to the Regional Prospective Observational Research for Tuberculosis (RePORT) International consortium, which studies TB in the context of HIV, and (3) support bi- directional mentorship and sharing around Harmonist tools, data management best practices, and data standards. This proposal is a collaboration among research informatics experts at Vanderbilt University Medical Center, all seven regional networks of IeDEA, and RePORT International. These partnerships ensure that all components of Harmonist address real-world user needs in a practical manner and provide the tools with a dedicated user base. We believe that these research tools can reduce the time and effort needed for critical data management and administrative tasks that underlie the role of observational HIV cohorts studying the global epidemic. The modular infrastructure we have designed can adapt to diverse research settings and expand to include new data types and sources as the understanding of HIV evolves. The resulting shareable software and mentoring resources will provide tangible immediate and long-term benefits to IeDEA, RePORT, and the broader HIV research community.

项目总结 协调全球多队列协作的数据所需的大量时间和精力可能会导致 研究延误，特别是考虑到数据、数据管理能力和数据共享的异质性 规章制度。和声项目的目标是开发数据标准、软件和方法，以帮助 艾滋病毒观察性研究联盟协调多区域研究项目和应用数据 更有成效和效率的管理最佳实践。为了促进可重用性，构建了和声工具 (如果可行)作为广泛使用的研究电子数据捕获的可共享外部模块 (RedCap)软件，截至2020年年中，138个国家的4,450多家机构正在使用该软件。首字母 Harmonist工具套件包括Harmonist Hub、科学项目和投资组合管理平台、 以及数据工具包，这是一个基于网络的数据质量检查和安全数据交换系统。 协调者项目旨在：(1)加强数据协调和财团对国际协调中心的支持 评估艾滋病流行病学数据库(IeDEA)联盟，包括提供一个新的数据框架 IeDEA前瞻性研究，(2)扩大对区域前瞻性观测研究的支持 结核病(报告)国际联合会，在艾滋病毒的背景下研究结核病，和(3)支持双边 围绕和声工具、数据管理最佳实践和数据进行定向指导和共享 标准。 这项提议是范德比尔特大学医学中心的研究信息学专家之间的合作 IeDEA和Report International的七个区域网络。这些伙伴关系确保所有组件 以实用的方式解决现实世界的用户需求，并为专门的用户提供工具 基地。我们相信，这些研究工具可以减少关键数据管理所需的时间和精力 以及管理任务，这些任务是研究全球流行病的观察艾滋病毒队列的作用的基础。这个 我们设计的模块化基础设施可以适应不同的研究环境，并扩展到包括新的 随着对艾滋病毒的了解的发展，数据类型和来源。由此产生的可共享软件和指导 资源将为IeDEA、Report和更广泛的HIV提供切实的即时和长期好处 研究社区。

项目成果

A Method for Generating Dashboard Aggregations in an International HIV Consortium.

• DOI: 10.3233/shti220261
• 发表时间: 2022-06-06
• 期刊: Studies in health technology and informatics
• 作者: Lewis, Judith T;Brazier, Ellen;Katz, Benjamin;Nash, Denis;Duda, Stephany N
• 通讯作者: Duda, Stephany N