Whole Eye Optical Coherence Tomography to Improve Eye Care

全眼光学相干断层扫描可改善眼部护理

基本信息

批准号：
10408816
负责人：
Anthony Nanlin Kuo
金额：
$ 36.76万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-12-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10408816
关键词：
3-Dimensional Accounting Adult Affect Anatomy Biomedical Engineering Biometry Caring Child Childhood Clinical Clinical Research Computer software Data Deformity Degenerative Myopia Descriptor Development Diagnostic Disease Early identification Edema Evolution Excision Eye Financial compensation Image Imaging technology Intracranial Hypertension Intracranial Pressure Laboratories Light Logistics Magnetic Resonance Imaging Measurement Morphologic artifacts Morphology Motion Myopia Ophthalmologist Optical Coherence Tomography Optics Outcome Pathologic Pathology Patient Care Patient imaging Patients Performance Peripheral Progressive Myopia Public Health Research Research Proposals Resolution Retina Shapes Site Source Swelling System Techniques Technology Testing Therapeutic Treatment Efficacy care providers case control clinical care clinical research site cost design diagnostic criteria disabling disease epidemiology study imaging biomarker imaging modality improved innovation morphometry multidisciplinary neuroimaging next generation novel retinal nerve fiber layer serial imaging skills

项目摘要

ABSTRACT This research proposal from a multi-disciplinary team including ophthalmologists and biomedical engineers seeks to improve the imaging and characterization of posterior eye deformities such as in progressive or pathologic myopic and high intracranial pressure. The three-dimensional changes seen in the posterior eye with these diseases have usually been characterized using neuro-imaging. To make this assessment more available in the clinical ophthalmic setting, we will further develop our “whole eye” optical coherence tomography (OCT) system specifically for this application. This OCT system will have hardware and software innovations to quantitatively assess the three-dimensional deformation of the posterior eye in these diseases. With these data, we can identify shape metrics which can help to distinguish pathologic from “regular” high myopia, progressive from non-progressive myopia, and for high intracranial pressure, we will assess the evolution of the eye deformation in the posterior eye over the patient’s care. These developments have both direct immediate clinical and research applicability by providing imaging biomarkers to characterize posterior eye deformation. In addition, given that a whole eye OCT system will be deployed to a second site, there will be a demonstration of the applicability of this technology outside the origin laboratory.

抽象的这项来自多学科团队的研究建议，包括眼科医生和生物医学工程师试图改善后验眼畸形的成像和表征，例如渐进式或病理近视和高颅内压。后眼中看到的三维变化这些疾病通常是使用神经图像来表征的。使这项评估更多在临床眼科环境中可用，我们将进一步发展我们的“全眼”光学连贯性层析成像（OCT）系统专门用于此应用。该OCT系统将具有硬件和软件定量评估这些疾病后眼的三维变形的创新。有了这些数据，我们可以识别形状指标，这可以帮助将病理学与“常规”高近视，从非促进性近视而进行的，对于高颅内压，我们将评估眼睛变形在患者护理的后视线中的演变。这些事态发展既可以通过提供成像直接立即临床和研究适用性生物标志物表征后眼形变形。此外，鉴于整个眼睛的OCT系统将是部署到第二个站点，将展示该技术在原点之外的适用性实验室。