Whole Eye Optical Coherence Tomography to Improve Eye Care

全眼光学相干断层扫描可改善眼部护理

• 批准号: 10408816
• 负责人: Anthony Nanlin Kuo
• 金额: $ 36.76万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10408816
• 关键词: 3-Dimensional; Accounting; Adult; Affect; Anatomy; Biomedical Engineering; Biometry; Caring; Child; Childhood; Clinical; Clinical Research; Computer software; Data; Deformity; Degenerative Myopia; Descriptor; Development; Diagnostic; Disease; Early identification; Edema; Evolution; Excision; Eye; Financial compensation; Image; Imaging technology; Intracranial Hypertension; Intracranial Pressure; Laboratories; Light; Logistics; Magnetic Resonance Imaging; Measurement; Morphologic artifacts; Morphology; Motion; Myopia; Ophthalmologist; Optical Coherence Tomography; Optics; Outcome; Pathologic; Pathology; Patient Care; Patient imaging; Patients; Performance; Peripheral; Progressive Myopia; Public Health; Research; Research Proposals; Resolution; Retina; Shapes; Site; Source; Swelling; System; Techniques; Technology; Testing; Therapeutic; Treatment Efficacy; care providers; case control; clinical care; clinical research site; cost; design; diagnostic criteria; disabling disease; epidemiology study; imaging biomarker; imaging modality; improved; innovation; morphometry; multidisciplinary; neuroimaging; next generation; novel; retinal nerve fiber layer; serial imaging; skills

ABSTRACT This research proposal from a multi-disciplinary team including ophthalmologists and biomedical engineers seeks to improve the imaging and characterization of posterior eye deformities such as in progressive or pathologic myopic and high intracranial pressure. The three-dimensional changes seen in the posterior eye with these diseases have usually been characterized using neuro-imaging. To make this assessment more available in the clinical ophthalmic setting, we will further develop our “whole eye” optical coherence tomography (OCT) system specifically for this application. This OCT system will have hardware and software innovations to quantitatively assess the three-dimensional deformation of the posterior eye in these diseases. With these data, we can identify shape metrics which can help to distinguish pathologic from “regular” high myopia, progressive from non-progressive myopia, and for high intracranial pressure, we will assess the evolution of the eye deformation in the posterior eye over the patient’s care. These developments have both direct immediate clinical and research applicability by providing imaging biomarkers to characterize posterior eye deformation. In addition, given that a whole eye OCT system will be deployed to a second site, there will be a demonstration of the applicability of this technology outside the origin laboratory.

抽象的 这项研究提案来自包括眼科医生和生物医学工程师在内的多学科团队 旨在改善眼后部畸形的成像和表征，例如进行性或 病理性近视和高颅压。后眼看到的三维变化 这些疾病通常使用神经影像学来表征。为了让这个评价更加 在临床眼科环境中可用，我们将进一步开发我们的“全眼”光学相干性 断层扫描 (OCT) 系统专门针对此应用。该OCT系统将具有硬件和软件 定量评估这些疾病中眼后部三维变形的创新。 有了这些数据，我们可以识别形状指标，这有助于区分病理性和“常规”高 近视、非进行性近视以及高颅压，我们将评估 患者护理过程中后眼变形的演变。 这些进展通过提供成像技术具有直接的临床和研究适用性 表征后眼变形的生物标志物。此外，鉴于全眼 OCT 系统将 部署到第二个站点时，将演示该技术在原点之外的适用性 实验室。