Whole Eye Optical Coherence Tomography to Improve Eye Care

摘要 这项研究提案来自包括眼科医生和生物医学工程师在内的多学科团队 旨在改善后部眼部畸形的成像和特征，如进展性或 病理性近视和高颅压。后部眼球的三维变化 通常使用神经成像来描述这些疾病的特征。为了让这项评估更有价值 可用于临床眼科设置，我们将进一步发展我们的“全眼”光学相干 层析成像(OCT)系统专门用于这一应用。该OCT系统将包括硬件和软件 在定量评估这些疾病中后眼球的三维变形方面的创新。 有了这些数据，我们就可以确定有助于区分病理性高血压和正常高血压的形状指标 近视，非进行性近视的进行性近视，以及对于高颅压，我们将评估 在患者护理过程中后部眼球变形的演变。 这些发展通过提供成像技术，直接适用于临床和研究。 用于表征眼睛后部变形的生物标志物。此外，鉴于整个眼科OCT系统将 部署到第二个地点，将展示这项技术在原产地以外的适用性 实验室。

ABSTRACT This research proposal from a multi-disciplinary team including ophthalmologists and biomedical engineers seeks to improve the imaging and characterization of posterior eye deformities such as in progressive or pathologic myopic and high intracranial pressure. The three-dimensional changes seen in the posterior eye with these diseases have usually been characterized using neuro-imaging. To make this assessment more available in the clinical ophthalmic setting, we will further develop our “whole eye” optical coherence tomography (OCT) system specifically for this application. This OCT system will have hardware and software innovations to quantitatively assess the three-dimensional deformation of the posterior eye in these diseases. With these data, we can identify shape metrics which can help to distinguish pathologic from “regular” high myopia, progressive from non-progressive myopia, and for high intracranial pressure, we will assess the evolution of the eye deformation in the posterior eye over the patient’s care. These developments have both direct immediate clinical and research applicability by providing imaging biomarkers to characterize posterior eye deformation. In addition, given that a whole eye OCT system will be deployed to a second site, there will be a demonstration of the applicability of this technology outside the origin laboratory.