Whole Eye Optical Coherence Tomography to Improve Eye Care

摘要 这项研究提案来自一个包括眼科医生和生物医学工程师在内的多学科团队， 寻求改善后眼畸形的成像和表征， 病理性近视和高颅内压。在后眼中看到的三维变化 通常使用神经成像来表征这些疾病。为了使这一评估更加 在临床眼科环境中可用，我们将进一步开发我们的“全眼”光学相干性 断层扫描（OCT）系统专门用于此应用。该OCT系统将具有硬件和软件 定量评估这些疾病中后眼的三维变形的创新。 有了这些数据，我们可以确定形状指标，这有助于区分病理性和“常规”高血压。 近视，进行性近视和非进行性近视，以及高颅内压，我们将评估 在患者的护理过程中，后眼中的眼睛变形的演变。 这些发展提供了直接的临床和研究的适用性， 生物标志物来表征后眼变形。此外，考虑到整个眼睛OCT系统将 部署到第二个站点，将演示该技术在原点之外的适用性 实验室

ABSTRACT This research proposal from a multi-disciplinary team including ophthalmologists and biomedical engineers seeks to improve the imaging and characterization of posterior eye deformities such as in progressive or pathologic myopic and high intracranial pressure. The three-dimensional changes seen in the posterior eye with these diseases have usually been characterized using neuro-imaging. To make this assessment more available in the clinical ophthalmic setting, we will further develop our “whole eye” optical coherence tomography (OCT) system specifically for this application. This OCT system will have hardware and software innovations to quantitatively assess the three-dimensional deformation of the posterior eye in these diseases. With these data, we can identify shape metrics which can help to distinguish pathologic from “regular” high myopia, progressive from non-progressive myopia, and for high intracranial pressure, we will assess the evolution of the eye deformation in the posterior eye over the patient’s care. These developments have both direct immediate clinical and research applicability by providing imaging biomarkers to characterize posterior eye deformation. In addition, given that a whole eye OCT system will be deployed to a second site, there will be a demonstration of the applicability of this technology outside the origin laboratory.