Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care

描述（由申请人提供）：这是一个由眼科医生和生物医学工程师组成的多学科团队提出的研究计划，旨在提高眼部OCT表征的准确性，从而提高临床和研究测量OCT图像的准确性。硬件和算法的创新，然后应用于两个重要的临床诊断测量。在前眼，角膜形状的精确测量决定了角膜屈光度。然而，在接受LASIK手术的个体中，目前的临床诊断无法准确测量这种形状，因此无法测量角膜屈光度。随着这些人年龄的增长，当他们以后需要通过白内障手术进行进一步的光学改造时，这可能导致在所有距离上完全依赖眼镜；这一差距已被国家眼科研究所认定为当务之急。在后面

DESCRIPTION (provided by applicant): This research proposal from a multi-disciplinary team of ophthalmologists and biomedical engineers seeks to improve the accuracy of OCT representations of the eye and hence the clinical and research measurements made from OCT images. Hardware and algorithmic innovations will be made and then applied to two important clinical diagnostic measurements. In the anterior eye, accurate measurement of corneal shape determines corneal refractive power. In individuals who have undergone LASIK, however, current clinical diagnostics cannot accurately measure this shape and hence cannot measure corneal refractive power. As these individuals age, this can result in complete spectacle dependency at all distances when they later require further optical modification with cataract surgery; this gap has been recognized as a priority by the National Eye Institute. In the posterior eye, ocular shape is correlated with pathology in myopia. Ocular shape is currently obtained using magnetic resonance imaging, and the attendant logistical and cost barriers with MRI limit the widespread use and investigation of these posterior eye measures. These developments have both direct immediate clinical and research applicability by enabling the specified measures as well as future implications for spatial measurements of the eye from OCT images.