Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care

全眼光学相干断层扫描可改善屈光手术和眼部护理

基本信息

批准号：
9189614
负责人：
Anthony Nanlin Kuo
金额：
$ 39.32万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-12-01 至 2019-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9189614
关键词：
Address Affect Age Algorithmic Software Algorithms Anterior Area Back Biological Markers Biomedical Engineering Biometry Caring Cataract Extraction Clinical Clinical Research Cornea Data Dependency Development Dimensions Event Eye Functional Imaging Future Geometry Health Image Imaging Techniques Individual Investigation Knowledge Lasers Lead Light Logistics Magnetic Resonance Imaging Maps Measurement Measures Mission Modernization Modification Motion Myopia National Eye Institute Operative Surgical Procedures Ophthalmologist Ophthalmology Optical Coherence Tomography Optics Outcome Pathology Patients Performance Positioning Attribute Public Health Quality of life Research Research Personnel Research Proposals Resolution Retina Scanning Shapes Specific qualifier value Structure Surface System Techniques Technology United States National Institutes of Health Variant Vendor Vision Vision research Visual aging population base clinical care clinical diagnostics cost diagnostic biomarker imaging system improved innovation lens metrology morphometry multidisciplinary next generation public health relevance reconstruction trend

项目摘要

DESCRIPTION (provided by applicant): This research proposal from a multi-disciplinary team of ophthalmologists and biomedical engineers seeks to improve the accuracy of OCT representations of the eye and hence the clinical and research measurements made from OCT images. Hardware and algorithmic innovations will be made and then applied to two important clinical diagnostic measurements. In the anterior eye, accurate measurement of corneal shape determines corneal refractive power. In individuals who have undergone LASIK, however, current clinical diagnostics cannot accurately measure this shape and hence cannot measure corneal refractive power. As these individuals age, this can result in complete spectacle dependency at all distances when they later require further optical modification with cataract surgery; this gap has been recognized as a priority by the National Eye Institute. In the posterior eye, ocular shape is correlated with pathology in myopia. Ocular shape is currently obtained using magnetic resonance imaging, and the attendant logistical and cost barriers with MRI limit the widespread use and investigation of these posterior eye measures. These developments have both direct immediate clinical and research applicability by enabling the specified measures as well as future implications for spatial measurements of the eye from OCT images.

描述（由申请人提供）：来自眼科医生和生物医学工程师的多学科团队的这项研究提案旨在提高眼睛的OCT表示的准确性，从而提高来自OCT图像的临床和研究测量。硬件和算法创新将进行，然后应用于两个重要的临床诊断测量。在前眼中，角膜形状的准确测量决定了角膜折射力。但是，在经历了LASIK的个体中，当前的临床诊断无法准确测量这种形状，因此无法测量角膜屈光能力。随着这些人的年龄，当他们以后需要进行白内障手术的进一步的光学修饰时，这可能会在各个距离上完全依赖。该差距已被国家眼科研究所（National Eye Institute）视为优先事项。在后部眼睛，眼形与近视的病理相关。目前使用磁共振成像获得眼形，并具有MRI限制的随之而来的后勤障碍和成本障碍，对这些后眼镜的广泛使用和研究。这些发展通过实现指定措施以及对OCT图像对眼睛的空间测量的未来影响，既具有直接的临床和研究适用性。