Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care

描述（由申请人提供）：本研究提案由眼科医生和生物医学工程师组成的多学科团队提出，旨在提高眼睛OCT表示的准确性，从而提高OCT图像的临床和研究测量的准确性。将进行硬件和算法创新，然后应用于两个重要的临床诊断测量。在前眼中，角膜形状的准确测量决定了角膜屈光力。然而，在接受LASIK的个体中，当前的临床诊断不能准确地测量这种形状，因此不能测量角膜屈光力。随着这些人年龄的增长，这可能导致在所有距离上完全依赖眼镜，当他们以后需要通过白内障手术进行进一步的光学修改时;国家眼科研究所已将此差距视为优先事项。在后 眼睛、眼睛形状与近视的病理相关。目前使用磁共振成像获得眼睛形状，并且伴随的MRI的后勤和成本障碍限制了这些后眼测量的广泛使用和研究。这些发展都直接立即临床和研究的适用性，使指定的措施，以及未来的影响，从OCT图像的眼睛的空间测量。

DESCRIPTION (provided by applicant): This research proposal from a multi-disciplinary team of ophthalmologists and biomedical engineers seeks to improve the accuracy of OCT representations of the eye and hence the clinical and research measurements made from OCT images. Hardware and algorithmic innovations will be made and then applied to two important clinical diagnostic measurements. In the anterior eye, accurate measurement of corneal shape determines corneal refractive power. In individuals who have undergone LASIK, however, current clinical diagnostics cannot accurately measure this shape and hence cannot measure corneal refractive power. As these individuals age, this can result in complete spectacle dependency at all distances when they later require further optical modification with cataract surgery; this gap has been recognized as a priority by the National Eye Institute. In the posterior eye, ocular shape is correlated with pathology in myopia. Ocular shape is currently obtained using magnetic resonance imaging, and the attendant logistical and cost barriers with MRI limit the widespread use and investigation of these posterior eye measures. These developments have both direct immediate clinical and research applicability by enabling the specified measures as well as future implications for spatial measurements of the eye from OCT images.