Whole Eye Optical Coherence Tomography to Improve Eye Care

全眼光学相干断层扫描可改善眼部护理

• 批准号: 10636956
• 负责人: Anthony Nanlin Kuo
• 金额: $ 40.01万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10636956
• 关键词: 3-Dimensional; Accounting; Adult; Affect; Anatomy; Biomedical Engineering; Biometry; Caring; Child; Childhood; Clinical; Clinical Research; Compensation; Computer software; Data; Deformity; Degenerative Myopia; Descriptor; Development; Disease; Disparity; Early identification; Edema; Evolution; Excision; Eye; Image; Imaging technology; Intracranial Hypertension; Intracranial Pressure; Laboratories; Light; Magnetic Resonance Imaging; Maps; Measurement; Morphologic artifacts; Morphology; Motion; Myopia; Ophthalmologist; Optical Coherence Tomography; Optics; Outcome; Pathologic; Pathology; Patient Care; Patient imaging; Patients; Performance; Peripheral; Progressive Myopia; Public Health; Research; Research Proposals; Resolution; Retina; Shapes; Site; Source; Swelling; System; Techniques; Technology; Testing; Therapeutic; Treatment Efficacy; Visual; care providers; clinical care; clinical research site; cost; design; diagnostic criteria; disabling disease; epidemiology study; imaging biomarker; imaging modality; improved; innovation; morphometry; multidisciplinary; neuroimaging; next generation; novel; retinal nerve fiber layer; serial imaging; skills

ABSTRACT This research proposal from a multi-disciplinary team including ophthalmologists and biomedical engineers seeks to improve the imaging and characterization of posterior eye deformities such as in progressive or pathologic myopic and high intracranial pressure. The three-dimensional changes seen in the posterior eye with these diseases have usually been characterized using neuro-imaging. To make this assessment more available in the clinical ophthalmic setting, we will further develop our “whole eye” optical coherence tomography (OCT) system specifically for this application. This OCT system will have hardware and software innovations to quantitatively assess the three-dimensional deformation of the posterior eye in these diseases. With these data, we can identify shape metrics which can help to distinguish pathologic from “regular” high myopia, progressive from non-progressive myopia, and for high intracranial pressure, we will assess the evolution of the eye deformation in the posterior eye over the patient’s care. These developments have both direct immediate clinical and research applicability by providing imaging biomarkers to characterize posterior eye deformation. In addition, given that a whole eye OCT system will be deployed to a second site, there will be a demonstration of the applicability of this technology outside the origin laboratory.

摘要 这项研究提案来自一个包括眼科医生和生物医学工程师在内的多学科团队， 寻求改善后眼畸形的成像和表征， 病理性近视和高颅内压。在后眼中看到的三维变化 通常使用神经成像来表征这些疾病。为了使这一评估更加 在临床眼科环境中可用，我们将进一步开发我们的“全眼”光学相干性 断层扫描（OCT）系统专门用于此应用。该OCT系统将具有硬件和软件 定量评估这些疾病中后眼的三维变形的创新。 有了这些数据，我们可以确定形状指标，这有助于区分病理性和“常规”高血压。 近视，进行性近视和非进行性近视，以及高颅内压，我们将评估 在患者的护理过程中，后眼中的眼睛变形的演变。 这些发展通过提供成像而具有直接的临床和研究适用性 生物标志物来表征后眼变形。此外，考虑到整个眼睛OCT系统将 部署到第二个站点，将演示该技术在原点之外的适用性 实验室

项目成果

QUANTITATIVE TOPOGRAPHIC CURVATURE MAPS OF THE POSTERIOR EYE UTILIZING OPTICAL COHERENCE TOMOGRAPHY.

使用光学相干断层扫描的后眼的定量地形曲率图。

• DOI: 10.1097/iae.0000000000002897
• 发表时间: 2021-04-01
• 期刊: Retina (Philadelphia, Pa.)
• 作者: McNabb RP;Liu AS;Gospe SM 3rd;El-Dairi M;Meekins LC;James C;Vann RR;Izatt JA;Kuo AN
• 通讯作者: Kuo AN

Posterior Eye Shape Measurement With Retinal OCT Compared to MRI.

• DOI: 10.1167/iovs.15-18886
• 发表时间: 2016-07-01
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Kuo AN;Verkicharla PK;McNabb RP;Cheung CY;Hilal S;Farsiu S;Chen C;Wong TY;Ikram MK;Cheng CY;Young TL;Saw SM;Izatt JA
• 通讯作者: Izatt JA

Four-dimensional Microscope-Integrated Optical Coherence Tomography to Visualize Suture Depth in Strabismus Surgery.

四维显微镜集成光学相干断层扫描可可视化斜视手术中的缝合深度。

• DOI: 10.3928/01913913-20170201-01
• 发表时间: 2017
• 期刊: Journal of pediatric ophthalmology and strabismus
• 影响因子: 1.2
• 作者: Pasricha,NeelD;Bhullar,ParamjitK;Shieh,Christine;Carrasco-Zevallos,OscarM;Keller,Brenton;Izatt,JosephA;Toth,CynthiaA;Freedman,SharonF;Kuo,AnthonyN
• 通讯作者: Kuo,AnthonyN

Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes.

• DOI: 10.1167/iovs.15-18818
• 发表时间: 2016-07-01
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Todorich B;Shieh C;DeSouza PJ;Carrasco-Zevallos OM;Cunefare DL;Stinnett SS;Izatt JA;Farsiu S;Mruthyunjaya P;Kuo AN;Toth CA
• 通讯作者: Toth CA

Robotically aligned optical coherence tomography with 5 degree of freedom eye tracking for subject motion and gaze compensation.

机器人对准的光学相干断层扫描具有 5 自由度眼球追踪功能，用于对象运动和注视补偿。

• DOI: 10.1364/boe.443537
• 发表时间: 2021
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Ortiz,Pablo;Draelos,Mark;Viehland,Christian;Qian,Ruobing;McNabb,RyanP;Kuo,AnthonyN;Izatt,JosephA
• 通讯作者: Izatt,JosephA