Whole Eye Optical Coherence Tomography to Improve Eye Care

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ABSTRACT This research proposal from a multi-disciplinary team including ophthalmologists and biomedical engineers seeks to improve the imaging and characterization of posterior eye deformities such as in progressive or pathologic myopic and high intracranial pressure. The three-dimensional changes seen in the posterior eye with these diseases have usually been characterized using neuro-imaging. To make this assessment more available in the clinical ophthalmic setting, we will further develop our “whole eye” optical coherence tomography (OCT) system specifically for this application. This OCT system will have hardware and software innovations to quantitatively assess the three-dimensional deformation of the posterior eye in these diseases. With these data, we can identify shape metrics which can help to distinguish pathologic from “regular” high myopia, progressive from non-progressive myopia, and for high intracranial pressure, we will assess the evolution of the eye deformation in the posterior eye over the patient’s care. These developments have both direct immediate clinical and research applicability by providing imaging biomarkers to characterize posterior eye deformation. In addition, given that a whole eye OCT system will be deployed to a second site, there will be a demonstration of the applicability of this technology outside the origin laboratory.