NIA/AA for Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (NIA/AA IMPACT-AD Course)

项目摘要 迫切需要改善阿尔茨海默病和相关痴呆（ADRD）的疗法。关键 开发ADRD治疗方法和遏制ADRD对公共卫生影响的使命将是新一代的 ADRD科学家，特别是具有设计和执行临床试验所需的独特培训和技能的科学家 审判这种培训很少通过传统的医学或生物统计教育课程提供。 此外，为了开发ADRD的改进疗法，临床试验中的多学科专业知识将是必要的， 包括医学专家，也包括生物统计学、生物标志物、试验设计、参与者招募、 研究组织和试验伦理。该提案要求支持在联合国系统内开展一项首创性的培训方案， ADRD试验的设计和实施的基本要素，将充分利用 阿尔茨海默氏症临床试验联盟（ACTC），并每年进行一次，以使各种各样的 临床医生，科学家和研究人员接受现代和强大的ADRD临床试验培训。

Project Summary There is an urgent need for improved therapies for Alzheimer’s Disease and Related Dementias (ADRD). Critical to the mission to develop treatments for and curb the public health impact of ADRD will be a new generation of ADRD scientists, especially scientists with the unique training and skills necessary to design and perform clinical trials. This training is rarely provided through the traditional course of medical or biostatistical education. Moreover, to develop improved therapies for ADRD, multidisciplinary expertise in clinical trials will be necessary, including medical specialists but also expertise in biostatistics, biomarkers, trial design, participant recruitment, study organization, and trial ethics. This proposal requests support for a first-of-its-kind training program in the essential elements of design and conduct of ADRD trials that will leverage the full infrastructure and expertise of the Alzheimer’s Clinical Trials Consortium (ACTC) and be conducted annually to enable a diverse range of clinicians, scientists and researchers to receive modern and robust training on ADRD clinical trials.