Recruiting multiethnic populations to preclinical Alzheimers disease trials

招募多种族人群参与临床前阿尔茨海默病试验

基本信息

  • 批准号:
    10677736
  • 负责人:
  • 金额:
    $ 19.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-15 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Preclinical Alzheimer’s disease clinical trials enroll cognitively normal participants who are willing to undergo disease biomarker testing, learn the results, and take an investigational drug (or placebo) if those results indicate that they are at increased risk for disease. Like traditional trials in Alzheimer’s disease dementia, these trials require participants to enroll with a study partner, a person who can attend visits with the participant and report about any changes in the participant’s cognitive or functional ability. These trials face difficult recruitment, especially in enrolling samples representative of the nation’s diverse population. Understanding potential differential attitudes toward the unique requirements in preclinical AD trials will be essential to instructing inclusive recruitment, enrollment, and conduct of preclinical AD trials. This project will examine potential differential attitudes toward preclinical AD trials among African American/Black, Asian American, Hispanic, and non-Hispanic White older cognitively unimpaired individuals. The project will focus on two key requirements in these trials: biomarker disclosure and the study partner requirement. There is strong rationale to hypothesize that these groups may differ in their attitudes toward these requirements. This includes our previous demonstration of differential attitudes toward the requirements based on whether an individual would enroll with a spouse as a study partner and the enrollment patterns of dyads in the first preclinical AD trial, the Anti-Amyloid treatment in Asymptomatic AD (A4) Study. In A4, 58% of non- Hispanic White participants enrolled with a spouse study partner, compared to 45% for Hispanic, 46% for Asian, and 27% for African American/Black participants. This project will provide critical data toward improving preclinical AD trial protocol designs and requirements, as well as practices in disclosure, to ensure diverse and inclusive recruitment that respects potential cultural differences in attitudes toward the requirements of these important studies.
项目摘要 临床前阿尔茨海默病临床试验招募认知正常的参与者,他们愿意接受 疾病生物标志物检测,了解结果,如果结果表明 他们患病的风险增加。就像阿尔茨海默病痴呆症的传统试验一样,这些试验 要求受试者与研究伙伴一起入组,研究伙伴可以与受试者一起参加访视并报告 参与者的认知或功能能力的任何变化。这些审判面临招募困难, 特别是在招募代表国家多样化人口的样本方面。了解潜力 对临床前AD试验中的独特要求的不同态度对于指导 包括招募、入组和进行临床前AD试验。 该项目将研究非洲人对临床前AD试验的潜在差异态度。 美国/黑人、亚裔美国人、西班牙裔和非西班牙裔白色老年认知未受损个体。 该项目将重点关注这些试验中的两个关键要求:生物标志物披露和研究伙伴 要求。有很强的理由假设这些群体对这些问题的态度可能不同, 要求.这包括我们之前对基于需求的不同态度的演示 关于一个人是否会与配偶一起作为研究伴侣登记,以及 首个临床前AD试验,无症状AD抗淀粉样蛋白治疗(A4)研究。在A4中,58%的非 西班牙裔白色参与者与配偶一起参加研究,而西班牙裔为45%,亚裔为46%, 非裔美国人/黑人参与者占27%。 该项目将为改善临床前AD试验方案设计和要求提供关键数据, 以及披露实践,以确保尊重潜在文化的多元化和包容性招聘 对这些重要研究要求的态度差异。

项目成果

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Joshua Grill其他文献

Joshua Grill的其他文献

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{{ truncateString('Joshua Grill', 18)}}的其他基金

Patient and Family Member Reactions to Biomarker-Informed ADRD Diagnoses
患者和家属对基于生物标志物的 ADRD 诊断的反应
  • 批准号:
    10589205
  • 财政年份:
    2023
  • 资助金额:
    $ 19.63万
  • 项目类别:
Collaborative Approach for Asian Americans, Native Hawaiians, and Pacific Islanders Research and Education (CARE) 2.0
亚裔美国人、夏威夷原住民和太平洋岛民研究与教育 (CARE) 2.0 合作方法
  • 批准号:
    10740342
  • 财政年份:
    2023
  • 资助金额:
    $ 19.63万
  • 项目类别:
Summer Medical student Aging and Alzheimer disease Research Training (SMAART) program
暑期医学生衰老和阿尔茨海默病研究培训 (SMAART) 计划
  • 批准号:
    10617758
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
NIA/AA for Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (NIA/AA IMPACT-AD Course)
NIA/AA ADRD 临床试验推进方法和方案研究所(NIA/AA IMPACT-AD 课程)
  • 批准号:
    10624324
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
Summer Medical student Aging and Alzheimer disease Research Training (SMAART) program
暑期医学生衰老和阿尔茨海默病研究培训 (SMAART) 计划
  • 批准号:
    10411754
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
Recruiting multiethnic populations to preclinical Alzheimers disease trials-Diversity Supplement
招募多种族人群参加临床前阿尔茨海默病试验-多样性补充
  • 批准号:
    10791432
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
Recruiting multiethnic populations to preclinical Alzheimers disease trials
招募多种族人群参与临床前阿尔茨海默病试验
  • 批准号:
    10518289
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
NIA/AA for Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (NIA/AA IMPACT-AD Course)
NIA/AA ADRD 临床试验推进方法和方案研究所(NIA/AA IMPACT-AD 课程)
  • 批准号:
    10410305
  • 财政年份:
    2022
  • 资助金额:
    $ 19.63万
  • 项目类别:
Training in Translational ADRD Neuroscience (TITAN)
转化 ADRD 神经科学培训 (TITAN)
  • 批准号:
    10270401
  • 财政年份:
    2021
  • 资助金额:
    $ 19.63万
  • 项目类别:
Training in Translational ADRD Neuroscience (TITAN)
转化 ADRD 神经科学培训 (TITAN)
  • 批准号:
    10475713
  • 财政年份:
    2021
  • 资助金额:
    $ 19.63万
  • 项目类别:

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