MUSCLE: MUsculoSkeletal Clinical Learning Experience Transdisciplinary Musculoskeletal Research Training Program

项目摘要 在美国，肌肉骨骼疾病影响超过一半的18岁及以上的人， 四分之三的人年龄在65岁及以上。肌肉骨骼疾病的影响将变得更加明显 随着老龄化人口的增加。结合临床需要的机理研究势在必行 开发新的治疗方法，但在肌肉骨骼领域的资金水平之间存在明显的不匹配， 研究及其对我们的医疗保健系统造成的财务和个人损失。我们的机构和整形外科 由于缺乏综合方案，社区一直在努力克服 在肌肉骨骼健康和有效转化为临床的机制研究。我们开发了 MUsculoSkills临床学习经验（肌肉）T32跨学科培训计划在加州大学戴维斯分校 以满足这一需求。该培训计划的总体目标是增加生物医学科学家的数量 在肌肉相关研究方面接受过培训，重点是了解临床需求和障碍。一 我们计划的新方面是总理肌肉骨骼研究的频繁互动和整合 教师在加州大学戴维斯分校领先的临床医生，再加上共同导师的机械和临床科学家， 为未来的肌肉骨骼健康研究人员提供精英培训经验。的目的 MUSCLE T32将提供为期两年的资助，跨学科，综合研究培训， 博士前的学生到研究人员能够解决有关的理解，预防， 治疗肌肉骨骼疾病。这种独特和综合的形式受益于共同董事， 机械和临床研究人员一样，协调一组选定的示范工程师，生物学家， 材料科学家，兽医和人类临床医生共同指导我们的学生，结合 精心设计，灵活的课程，为肌肉骨骼的博士前学生提供深入的培训 健康研究。随着每年招募3名新参与者，学员将参加几个临床 沉浸式体验，他们将讨论临床医生的需求以及研究进展如何 应对这些挑战。我们的计划强调研究技术的基本原理， 在法官席上进行定量技能培训，提供公开演讲和外联的机会， 建议书写作技巧，提供了一系列丰富的课外机会，并将医学和 科学/工程贯穿全年的培训。建立明确的监督机制， 15名学员在整个项目中取得的进展。通过在一个环境和文化中进行培训， 跨学科的支持机制研究和频繁的临床参与，有一个重要的 受训者在其职业生涯中对肌肉骨骼健康研究保持兴趣的可能性。

PROJECT SUMMARY Within the United States, musculoskeletal disease affects more than half of people aged 18 and over and nearly three out of four aged 65 and over. The impact of musculoskeletal disease will become even more pronounced with the increase in the aging population. Mechanistic research that is integrated with clinical need is imperative to develop new treatment approaches, yet there is a stark mismatch between funding levels in musculoskeletal research and its financial and personal toll on our healthcare system. Our institution and the orthopaedic community, due to a lack of integrated programs, have struggled to overcome the disconnect between mechanistic research in musculoskeletal health and effective translation into the clinic. We developed the MUsculoSkeletal Clinical Learning Experience (MUSCLE) T32 Transdisciplinary Training Program at UC Davis to meet this need. The overall objective of this training program is to increase the number of biomedical scientists trained in musculoskeletal-related research with an emphasis on understanding clinical needs and obstacles. A novel aspect of our program is the frequent interaction and integration of premier musculoskeletal research faculty with leading clinicians at UC Davis, coupled with co-mentorship by mechanistic and clinical scientists, providing an elite training experience for future researchers in musculoskeletal health. The objective of the MUSCLE T32 is to provide two years of funded, transdisciplinary, integrated research training to develop predoctoral students into researchers capable of solving issues relevant to the understanding, prevention, and treatment of musculoskeletal diseases. This unique and integrated format benefits from co-directorship by mechanistic and clinical researchers alike, coordinating a select group of exemplary engineers, biologists, materials scientists, veterinarians, and human clinicians to co-mentor our students, in combination with a carefully designed, flexible curriculum that provides in-depth training for predoctoral students in musculoskeletal health research. With the recruitment of 3 new participants each year, trainees will partake in several clinical immersive experiences, where they will discuss the needs of the clinician and how research advancements can address these challenges. Our program emphasizes fundamentals in research techniques that broaden research training at the bench with quantitative skills, provides opportunities for public speaking and outreach, builds proposal writing skills, provides a range of enriching extracurricular opportunities, and integrates medicine and science/engineering throughout all years of training. Defined oversight mechanisms are in place to track the progress of the 15 trainees throughout the program. By training in an environment and culture that gives strong interdisciplinary support for mechanistic research and frequent clinical engagement, there is a significant probability that the trainees will sustain an interest in musculoskeletal health research over their careers.