MUSCLE: MUsculoSkeletal Clinical Learning Experience Transdisciplinary Musculoskeletal Research Training Program

项目总结 在美国，肌肉骨骼疾病影响着超过一半的18岁及以上的人，近 四分之三的人年龄在65岁及以上。肌肉骨骼疾病的影响将变得更加明显 随着老龄化人口的增加。与临床需求相结合的机制研究势在必行 开发新的治疗方法，但在肌肉骨骼领域的资金水平之间存在明显的不匹配 研究及其对我们医疗体系的财务和个人损失。我们的机构和整形外科 由于缺乏综合方案，社区一直在努力克服 肌肉骨骼健康的机理研究和有效转化为临床。我们开发了 加州大学戴维斯分校肌肉骨骼临床学习经验(肌肉)T32跨学科培训计划 以满足这一需求。该培训计划的总体目标是增加生物医学科学家的数量 接受肌肉骨骼相关研究方面的培训，重点是了解临床需求和障碍。一个 我们计划的新方面是一流肌肉骨骼研究的频繁互动和整合 加州大学戴维斯分校拥有顶尖临床医生的教职员工，以及机械科学家和临床科学家的共同指导， 为未来的肌肉骨骼健康研究人员提供精英培训体验。该计划的目标是 肌肉T32是提供两年的资金，跨学科，综合研究培训，以开发 将博士后转化为能够解决相关问题的研究人员，了解、预防和 肌肉骨骼疾病的治疗。这一独特的综合格式受益于联合董事职位，由 机械学和临床研究人员一样，协调一组优秀的工程师、生物学家、 材料科学家、兽医和人类临床医生共同指导我们的学生，结合 精心设计、灵活的课程，为博士生提供肌肉骨骼学的深入培训 健康研究。随着每年招募3名新参与者，学员将参与几个临床 身临其境的体验，他们将在其中讨论临床医生的需求以及研究进展如何 应对这些挑战。我们的计划强调扩大研究范围的研究方法的基础知识 在替补席上接受量化技能培训，提供公开演讲和外联的机会，建立 提案写作技巧，提供了一系列丰富的课外机会，并将医学和 理工科在所有年头的训练中。制定了明确的监督机制，以跟踪 15名实习生在整个计划中的进展情况。通过在环境和文化中进行培训， 对机械性研究的跨学科支持和频繁的临床参与，有重要的 受训者在其职业生涯中对肌肉骨骼健康研究保持兴趣的可能性。

PROJECT SUMMARY Within the United States, musculoskeletal disease affects more than half of people aged 18 and over and nearly three out of four aged 65 and over. The impact of musculoskeletal disease will become even more pronounced with the increase in the aging population. Mechanistic research that is integrated with clinical need is imperative to develop new treatment approaches, yet there is a stark mismatch between funding levels in musculoskeletal research and its financial and personal toll on our healthcare system. Our institution and the orthopaedic community, due to a lack of integrated programs, have struggled to overcome the disconnect between mechanistic research in musculoskeletal health and effective translation into the clinic. We developed the MUsculoSkeletal Clinical Learning Experience (MUSCLE) T32 Transdisciplinary Training Program at UC Davis to meet this need. The overall objective of this training program is to increase the number of biomedical scientists trained in musculoskeletal-related research with an emphasis on understanding clinical needs and obstacles. A novel aspect of our program is the frequent interaction and integration of premier musculoskeletal research faculty with leading clinicians at UC Davis, coupled with co-mentorship by mechanistic and clinical scientists, providing an elite training experience for future researchers in musculoskeletal health. The objective of the MUSCLE T32 is to provide two years of funded, transdisciplinary, integrated research training to develop predoctoral students into researchers capable of solving issues relevant to the understanding, prevention, and treatment of musculoskeletal diseases. This unique and integrated format benefits from co-directorship by mechanistic and clinical researchers alike, coordinating a select group of exemplary engineers, biologists, materials scientists, veterinarians, and human clinicians to co-mentor our students, in combination with a carefully designed, flexible curriculum that provides in-depth training for predoctoral students in musculoskeletal health research. With the recruitment of 3 new participants each year, trainees will partake in several clinical immersive experiences, where they will discuss the needs of the clinician and how research advancements can address these challenges. Our program emphasizes fundamentals in research techniques that broaden research training at the bench with quantitative skills, provides opportunities for public speaking and outreach, builds proposal writing skills, provides a range of enriching extracurricular opportunities, and integrates medicine and science/engineering throughout all years of training. Defined oversight mechanisms are in place to track the progress of the 15 trainees throughout the program. By training in an environment and culture that gives strong interdisciplinary support for mechanistic research and frequent clinical engagement, there is a significant probability that the trainees will sustain an interest in musculoskeletal health research over their careers.