10-Year Changes in Objectively-Measured Physical Activity and Sedentary Behavior in the CARDIA Cohort

CARDIA 队列中客观测量的体力活动和久坐行为的 10 年变化

• 批准号: 9130387
• 负责人: Kelley Pettee Gabriel
• 金额: $ 68.92万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9130387
• 关键词: Acute; Address; Adult; Aerobic; Age; Age-Years; Aging; American; Ancillary Study; Atherosclerosis; Behavior; Biological Assay; Calibration; Cardiovascular Diseases; Cardiovascular system; Cell Aging; Chronic; Chronic Disease; Clinical; Cohort Studies; Collection; Coronary Artery Risk Development in Young Adults Study; Coronary artery; DNA; Data; Demographic Factors; Development; Disease; Disease Marker; Disease Outcome; Dyslipidemias; Epidemiologic Studies; Event; Exercise; Funding; Gender; Goals; Gold; Guidelines; Health; Health Benefit; Health Promotion; Heart failure; Hypertension; Individual; Knowledge; Length; Leukocytes; Life; Light; Maintenance; Measurement; Measures; Methods; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Onset of illness; Outcome; Participant; Patient Self-Report; Pattern; Performance; Physical Function; Physical activity; Population; Population Study; Positioning Attribute; Procedures; Protocols documentation; Psychosocial Factor; Public Health; Quality of life; Race; Research Design; Risk; Risk Factors; Risk Marker; Role; Site; Social Network; Stroke; Symptoms; Testing; Time; Treadmill Tests; Walking; Woman; Work; age effect; base; behavior change; cardiometabolic risk; cardiovascular disorder risk; cognitive function; cognitive performance; cohort; depressive symptoms; disability; disorder prevention; disorder risk; high risk; light intensity; men; meter; middle age; performance tests; prospective; public health research; sedentary; telomere; young adult

 DESCRIPTION (provided by applicant): Given the aging of the U.S. population, identifying strategies to optimize disease prevention and promote successful aging has important public health significance. Although the health benefits of regular moderate to vigorous intensity physical activity (MVPA) are well established, the health benefits of light intensity PA, the changes in PA and sedentary behavior (SB) during adulthood, and the role of these changes in health promotion and disease prevention are largely unknown. With data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, the overall goal of this proposal is to evaluate the 10-year changes in objectively- measured PA and SB from early (ages 38-50) to late (ages 48-60) midlife in relation to cardiovascular disease risk and markers of successful aging, including physical and cognitive function and leukocyte telomere length (a cellular marker of cardiovascular aging). Participants will be all those who attend the CARDIA Year 30 core exam (June 2015 to May 2016) and agree to the ancillary study procedures (n~2,928). The protocol will include: 1) seven days of accelerometry (ActiGraph wGT3X-BT); 2) physical performance tests; and 3) DNA extraction from stored buffy coats for assays of leukocyte telomere length. Year 30 cognitive function data will come from a separately funded ancillary study. In addition, 100 participants from each race/gender group (total n=400) will participate in a sub-study designed to validate the 400 meter walk physical performance test as a measure of aerobic capacity, using the duration of a symptom-limited graded exercise treadmill test as the gold standard. These same 400 participants will also participate in a calibration study to adjust estimates of PA and SB from the Actigraph 7164 (used at Year 20) to the Actigraph wGT3X-BT. To accomplish these goals, we propose the following specific aims: 1) Describe patterns of change in accelerometer-measured PA and SB over 10-years and determine if these patterns vary by race, gender, and other socio-demographic and psychosocial factors; 2) Investigate independent and interactive associations of declines, maintenance (high vs. low), and increases in objectively-measured PA and SB over 10-years with risk of cardiometabolic disease (obesity, hypertension, dyslipidemia, type 2 diabetes mellitus, subclinical atherosclerosis, and clinical endpoints) at Year 30; and 3) Investigate independent and interactive associations of declines, maintenance, and increases in objectively- measured PA and SB over 10-years on cellular aging (from Years 20 to 30) and, on Year 30 cognitive and physical functioning. This proposed work has important public health significance because CARDIA will be the first U.S. cardiovascular cohort study with repeat, objective measures of PA and SB, uniquely positioning this study to examine the effects of PA and SB change on relevant indicators of successful aging and disease risk within an initially young and healthy biracial study population that is now middle-aged and at increasing risk for onset of disease and disability.

 描述（由申请人提供）：鉴于美国人口老龄化，确定优化疾病预防和促进成功老龄化的策略具有重要的公共卫生意义。虽然定期中等强度到剧烈强度的体力活动（MVPA）的健康益处已经得到了很好的证实，但轻度PA的健康益处，成年期PA和久坐行为（SB）的变化，以及这些变化在促进健康和预防疾病方面的作用在很大程度上是未知的。根据来自年轻人冠状动脉风险发展（CARDIA）研究的数据，本提案的总体目标是评估客观测量的PA和SB的10年变化，（38-50岁）至晚期（48-60岁）中年与心血管疾病风险和成功衰老标志物的关系，包括身体和认知功能以及白细胞端粒长度（心血管老化的细胞标志）。参与者将是所有参加CARDIA 30年级核心考试（2015年6月至2016年5月）并同意辅助研究程序的人员（n~ 2，928）。方案将包括：1）七天的加速度计（ActiGraph wGT 3X-BT）; 2）物理性能测试;和3）从储存的血沉棕黄层提取DNA用于白细胞端粒长度的测定。第30年的认知功能数据将来自一项单独资助的辅助研究。此外，来自每个种族/性别组的100名受试者（总计n=400）将参加一项子研究，该子研究旨在验证400米步行体能测试作为有氧能力的测量方法，并使用极限分级运动跑步机测试的持续时间作为金标准。同样的400名参与者还将参与校准研究，以将Actigraph 7164（在第20年使用）的PA和SB估计值调整为Actigraph wGT 3X-BT。为了实现这些目标，我们提出了以下具体目标：1）描述10年来加速度计测量的PA和SB的变化模式，并确定这些模式是否因种族、性别和其他社会人口统计学和心理社会因素而异; 2）调查衰退、维持和衰退之间的独立和交互关联。（高vs.低），以及10年内客观测量的PA和SB增加，伴有心脏代谢疾病风险（肥胖、高血压、血脂异常、2型糖尿病、亚临床动脉粥样硬化和临床终点）;和3）调查10年内客观测量的PA和SB的下降、维持和增加与细胞老化（从20岁到30岁）和30岁认知和身体功能的独立和交互关联。这项拟议的工作具有重要的公共卫生意义，因为CARDIA将是美国第一项重复、客观测量PA和SB的心血管队列研究，独特定位这项研究，以检查PA和SB变化对成功老龄化和疾病风险的相关指标的影响，在最初年轻和健康的birthday研究人群中，现在是中期，老年人发病和残疾的风险越来越大。